Should you encounter any unexpected behaviour,
please let us know.

* *

B-factor analysis for ID 2402071700381855122

Overall B-factor prediction

Correlation= 0.443 for 370 C-alpha atoms.

B-factors for all residues

Residue-by-residue B-factor prediction for CA atoms

B-factors are computed based on the first 100 normal modes (B-PREDICT) and are scaled to match the overall B-factors in the submitted model (B-SCALED). A high correlation with the observations is an indicator that the normal modes capture well the overall flexibility features of the model. Comparison of the observed (B-OBS, blue) and the computed (B-SCALED, red) B-factors for all C-alpha atoms is presented below. Differences between B-factors from normal mode analysis and from X-ray crystallographic data may for example indicate regions where the protein flexibility is modified due to external factors such as tight crystall-packing.

ATOM TYP RES RESID B-PREDICT B-SCALED B-OBS	B-SCALED	B-OBS
2 CA MET 1 0.0160 2.0736 3.3200
21 CA THR 2 0.0188 2.3498 3.2300
35 CA GLU 3 0.0206 2.5196 3.0100
50 CA GLY 4 0.0210 2.5616 2.6600
57 CA GLU 5 0.0163 2.1048 2.2300
72 CA GLY 6 0.0176 2.2282 1.8000
79 CA GLN 7 0.0102 1.5123 1.4500
96 CA PHE 8 0.0069 1.1952 1.2000
116 CA TYR 9 0.0080 1.2998 1.0500
137 CA SER 10 0.0095 1.4438 0.9900
148 CA VAL 11 0.0092 1.4124 1.0000
164 CA GLN 12 0.0140 1.8784 1.0600
181 CA VAL 13 0.0146 1.9437 1.1500
197 CA GLY 14 0.0292 3.3547 1.2200
204 CA ASP 15 0.0409 4.4963 1.2600
216 CA SER 16 0.0159 2.0643 1.2500
227 CA THR 17 0.0106 1.5556 1.2000
241 CA PHE 18 0.0065 1.1577 1.1300
261 CA THR 19 0.0047 0.9839 1.0600
275 CA VAL 20 0.0035 0.8660 1.0200
291 CA LEU 21 0.0039 0.9051 0.9800
310 CA ARG 22 0.0064 1.1476 0.9600
334 CA ARG 23 0.0051 1.0177 0.9400
358 CA TYR 24 0.0042 0.9340 0.9200
379 CA GLN 25 0.0072 1.2222 0.8900
396 CA GLN 26 0.0105 1.5383 0.8800
413 CA LEU 27 0.0078 1.2772 0.8800
432 CA ARG 28 0.0108 1.5748 0.9200
456 CA ALA 29 0.0089 1.3917 0.9900
466 CA ILE 30 0.0093 1.4232 1.1000
485 CA GLY 31 0.0193 2.4015 1.2400
492 CA SER 32 0.0171 2.1840 1.3800
503 CA GLY 33 0.0297 3.4105 1.4600
510 CA ALA 34 0.0210 2.5614 1.4700
520 CA GLN 35 0.0047 0.9768 1.4000
537 CA GLY 36 0.0053 1.0408 1.2900
544 CA ILE 37 0.0058 1.0836 1.1600
563 CA VAL 38 0.0049 0.9962 1.0600
579 CA CYS 39 0.0051 1.0151 1.0000
590 CA SER 40 0.0053 1.0345 0.9900
601 CA ALA 41 0.0048 0.9853 1.0300
611 CA LEU 42 0.0060 1.1092 1.1100
630 CA ASP 43 0.0054 1.0438 1.2100
642 CA THR 44 0.0081 1.3056 1.3200
656 CA VAL 45 0.0089 1.3897 1.4100
672 CA LEU 46 0.0087 1.3659 1.4400
691 CA GLY 47 0.0102 1.5166 1.4000
698 CA VAL 48 0.0077 1.2700 1.2900
714 CA PRO 49 0.0056 1.0690 1.1600
728 CA VAL 50 0.0034 0.8549 1.0300
744 CA ALA 51 0.0029 0.8019 0.9300
754 CA VAL 52 0.0022 0.7391 0.8700
770 CA LYS 53 0.0023 0.7415 0.8500
792 CA LYS 54 0.0025 0.7646 0.8600
814 CA LEU 55 0.0026 0.7763 0.9000
833 CA SER 56 0.0040 0.9149 0.9300
844 CA ARG 57 0.0066 1.1606 0.9700
868 CA PRO 58 0.0041 0.9195 1.0000
882 CA PHE 59 0.0055 1.0562 1.0200
902 CA GLN 60 0.0100 1.4940 1.0400
919 CA ASN 61 0.0089 1.3881 1.0600
933 CA GLN 62 0.0075 1.2528 1.0700
950 CA THR 63 0.0060 1.1011 1.0800
964 CA HIS 64 0.0048 0.9919 1.0900
981 CA ALA 65 0.0036 0.8756 1.0800
991 CA LYS 66 0.0032 0.8311 1.0700
1013 CA ARG 67 0.0022 0.7373 1.0600
1037 CA ALA 68 0.0019 0.7109 1.0500
1047 CA TYR 69 0.0019 0.7074 1.0400
1068 CA ARG 70 0.0017 0.6908 1.0500
1092 CA GLU 71 0.0015 0.6712 1.0500
1107 CA LEU 72 0.0012 0.6436 1.0700
1126 CA VAL 73 0.0017 0.6883 1.1100
1142 CA LEU 74 0.0016 0.6810 1.1600
1161 CA LEU 75 0.0016 0.6791 1.2200
1180 CA LYS 76 0.0018 0.6980 1.2900
1202 CA CYS 77 0.0024 0.7530 1.3400
1213 CA VAL 78 0.0021 0.7256 1.3400
1229 CA ASN 79 0.0025 0.7659 1.3000
1243 CA HIS 80 0.0023 0.7479 1.2300
1260 CA LYS 81 0.0029 0.8053 1.1500
1282 CA ASN 82 0.0021 0.7218 1.0800
1296 CA ILE 83 0.0017 0.6920 1.0400
1315 CA ILE 84 0.0018 0.6997 1.0200
1334 CA HIS 85 0.0020 0.7147 1.0200
1351 CA LEU 86 0.0015 0.6703 1.0300
1370 CA LEU 87 0.0025 0.7612 1.0400
1389 CA ASN 88 0.0019 0.7077 1.0400
1403 CA VAL 89 0.0013 0.6498 1.0500
1419 CA PHE 90 0.0015 0.6677 1.0600
1439 CA THR 91 0.0025 0.7672 1.0800
1453 CA PRO 92 0.0038 0.8892 1.1000
1467 CA GLN 93 0.0066 1.1613 1.1000
1484 CA LYS 94 0.0112 1.6113 1.1000
1506 CA SER 95 0.0099 1.4870 1.0800
1517 CA LEU 96 0.0067 1.1704 1.0500
1536 CA GLU 97 0.0150 1.9795 1.0200
1551 CA GLU 98 0.0111 1.5977 1.0000
1566 CA PHE 99 0.0047 0.9837 0.9700
1586 CA GLN 100 0.0055 1.0553 0.9600
1603 CA ASP 101 0.0029 0.8085 0.9400
1615 CA LEU 102 0.0018 0.7005 0.9300
1634 CA TYR 103 0.0014 0.6588 0.9300
1655 CA LEU 104 0.0012 0.6433 0.9500
1674 CA VAL 105 0.0014 0.6566 0.9800
1690 CA MET 106 0.0018 0.6981 1.0300
1707 CA GLU 107 0.0027 0.7876 1.0900
1722 CA LEU 108 0.0034 0.8518 1.1100
1741 CA MET 109 0.0035 0.8587 1.1000
1758 CA ASP 110 0.0052 1.0287 1.0600
1770 CA ALA 111 0.0048 0.9854 1.0000
1780 CA SER 112 0.0040 0.9097 0.9400
1791 CA LEU 113 0.0028 0.7908 0.8900
1810 CA CYS 114 0.0039 0.8973 0.8600
1821 CA GLN 115 0.0067 1.1697 0.8700
1838 CA VAL 116 0.0043 0.9390 0.9100
1854 CA ILE 117 0.0040 0.9098 0.9700
1873 CA HIS 118 0.0082 1.3149 1.0500
1890 CA MET 119 0.0108 1.5680 1.1300
1907 CA ASP 120 0.0186 2.3329 1.1900
1919 CA LEU 121 0.0043 0.9393 1.2200
1938 CA ASP 122 0.0046 0.9713 1.1900
1950 CA HIS 123 0.0033 0.8408 1.1300
1967 CA GLU 124 0.0037 0.8823 1.0400
1982 CA ARG 125 0.0028 0.7946 0.9500
2006 CA MET 126 0.0021 0.7247 0.8600
2023 CA SER 127 0.0019 0.7064 0.7900
2034 CA TYR 128 0.0021 0.7262 0.7300
2055 CA LEU 129 0.0017 0.6858 0.6900
2074 CA LEU 130 0.0012 0.6440 0.6600
2093 CA TYR 131 0.0016 0.6771 0.6400
2114 CA GLN 132 0.0018 0.6967 0.6400
2131 CA ILE 133 0.0013 0.6510 0.6400
2150 CA LEU 134 0.0012 0.6425 0.6500
2169 CA CYS 135 0.0016 0.6809 0.6600
2180 CA GLY 136 0.0017 0.6871 0.6800
2187 CA ILE 137 0.0015 0.6668 0.7000
2206 CA ARG 138 0.0019 0.7051 0.7300
2230 CA HIS 139 0.0021 0.7265 0.7700
2247 CA LEU 140 0.0018 0.6994 0.8100
2266 CA HIS 141 0.0020 0.7162 0.8600
2283 CA SER 142 0.0027 0.7854 0.8900
2294 CA ALA 143 0.0029 0.8081 0.9200
2304 CA GLY 144 0.0029 0.8070 0.9300
2311 CA ILE 145 0.0018 0.6956 0.9200
2330 CA ILE 146 0.0018 0.6970 0.9000
2349 CA HIS 147 0.0015 0.6700 0.8800
2366 CA ARG 148 0.0016 0.6737 0.8500
2390 CA ASP 149 0.0016 0.6821 0.8200
2402 CA LEU 150 0.0014 0.6602 0.8000
2421 CA LYS 151 0.0019 0.7029 0.7700
2443 CA PRO 152 0.0021 0.7282 0.7600
2457 CA SER 153 0.0026 0.7760 0.7400
2468 CA ASN 154 0.0021 0.7291 0.7400
2482 CA ILE 155 0.0019 0.7113 0.7500
2501 CA VAL 156 0.0022 0.7410 0.7900
2517 CA VAL 157 0.0028 0.7951 0.8300
2533 CA LYS 158 0.0039 0.9026 0.8700
2555 CA SER 159 0.0130 1.7871 0.9000
2566 CA ASP 160 0.0129 1.7753 0.9100
2578 CA CYS 161 0.0037 0.8861 0.8900
2589 CA THR 162 0.0032 0.8286 0.8600
2603 CA LEU 163 0.0019 0.7073 0.8400
2622 CA LYS 164 0.0019 0.7091 0.8300
2644 CA ILE 165 0.0016 0.6738 0.8500
2663 CA LEU 166 0.0018 0.6926 0.9000
2682 CA ASP 167 0.0017 0.6857 0.9500
2694 CA PHE 168 0.0016 0.6803 1.0000
2714 CA GLY 169 0.0019 0.7099 1.0400
2721 CA LEU 170 0.0020 0.7152 1.0800
2740 CA ALA 171 0.0019 0.7096 1.1200
2750 CA ARG 172 0.0021 0.7261 1.1900
2774 CA THR 173 0.0028 0.7939 1.3000
2788 CA ALA 174 0.0031 0.8256 1.4400
2798 CA CYS 175 0.0072 1.2189 1.6400
2809 CA THR 176 0.0060 1.1011 1.8600
2823 CA ASN 177 0.0039 0.9005 2.1100
2837 CA PHE 178 0.0034 0.8545 2.3700
2857 CA MET 179 0.0035 0.8624 2.6100
2874 CA MET 180 0.0031 0.8263 2.7800
2891 CA THR 181 0.0061 1.1120 2.8200
2905 CA PRO 182 0.0062 1.1246 2.6900
2919 CA TYR 183 0.0114 1.6331 2.3800
2940 CA VAL 184 0.0070 1.2056 1.9900
2956 CA VAL 185 0.0030 0.8173 1.5900
2972 CA THR 186 0.0027 0.7868 1.2600
2986 CA ARG 187 0.0032 0.8324 1.0200
3010 CA TYR 188 0.0029 0.7999 0.8600
3031 CA TYR 189 0.0016 0.6759 0.7800
3052 CA ARG 190 0.0015 0.6700 0.7400
3076 CA ALA 191 0.0014 0.6598 0.7300
3086 CA PRO 192 0.0016 0.6826 0.7500
3100 CA GLU 193 0.0019 0.7044 0.7900
3115 CA VAL 194 0.0020 0.7139 0.8400
3131 CA ILE 195 0.0028 0.7906 0.9200
3150 CA LEU 196 0.0033 0.8396 1.0100
3169 CA GLY 197 0.0044 0.9485 1.0900
3176 CA MET 198 0.0039 0.8970 1.1600
3193 CA LYS 199 0.0052 1.0258 1.1800
3215 CA TYR 200 0.0029 0.8026 1.1600
3236 CA LYS 201 0.0026 0.7750 1.1000
3258 CA GLU 202 0.0019 0.7118 1.0100
3273 CA ASN 203 0.0016 0.6734 0.9100
3287 CA VAL 204 0.0013 0.6474 0.8200
3303 CA ASP 205 0.0012 0.6406 0.7500
3315 CA ILE 206 0.0010 0.6233 0.7000
3334 CA TRP 207 0.0010 0.6182 0.6700
3358 CA SER 208 0.0012 0.6346 0.6400
3369 CA VAL 209 0.0010 0.6204 0.6400
3385 CA GLY 210 0.0010 0.6169 0.6400
3392 CA CYS 211 0.0012 0.6399 0.6400
3403 CA ILE 212 0.0013 0.6460 0.6500
3422 CA MET 213 0.0013 0.6537 0.6700
3439 CA GLY 214 0.0016 0.6742 0.6900
3446 CA GLU 215 0.0021 0.7241 0.7200
3461 CA MET 216 0.0019 0.7117 0.7500
3478 CA VAL 217 0.0026 0.7767 0.7900
3494 CA LYS 218 0.0033 0.8478 0.8200
3516 CA GLY 219 0.0041 0.9172 0.8400
3523 CA SER 220 0.0041 0.9175 0.8600
3534 CA VAL 221 0.0028 0.7936 0.8600
3550 CA ILE 222 0.0023 0.7491 0.8800
3569 CA PHE 223 0.0026 0.7789 0.9200
3589 CA GLN 224 0.0039 0.9038 0.9700
3606 CA GLY 225 0.0067 1.1777 1.0300
3613 CA THR 226 0.0123 1.7218 1.0900
3627 CA ASP 227 0.0074 1.2422 1.1200
3639 CA HIS 228 0.0051 1.0169 1.1000
3656 CA ILE 229 0.0058 1.0905 1.0500
3675 CA ASP 230 0.0061 1.1178 0.9700
3687 CA GLN 231 0.0033 0.8437 0.8800
3704 CA TRP 232 0.0028 0.7920 0.8100
3728 CA ASN 233 0.0045 0.9566 0.7600
3742 CA LYS 234 0.0042 0.9305 0.7200
3764 CA VAL 235 0.0026 0.7766 0.7000
3780 CA ILE 236 0.0034 0.8525 0.6800
3799 CA GLU 237 0.0048 0.9896 0.6700
3814 CA ILE 238 0.0039 0.9016 0.6700
3833 CA LEU 239 0.0032 0.8344 0.6700
3852 CA GLY 240 0.0048 0.9853 0.6800
3859 CA THR 241 0.0056 1.0680 0.7000
3873 CA PRO 242 0.0050 1.0060 0.7100
3887 CA SER 243 0.0105 1.5456 0.7300
3898 CA LEU 244 0.0120 1.6901 0.7600
3917 CA GLU 245 0.0117 1.6635 0.7800
3932 CA PHE 246 0.0058 1.0864 0.8100
3952 CA MET 247 0.0065 1.1545 0.8400
3969 CA ASN 248 0.0106 1.5483 0.8900
3983 CA ARG 249 0.0063 1.1325 0.9500
4007 CA LEU 250 0.0059 1.0913 1.0100
4026 CA MET 251 0.0126 1.7462 1.0500
4043 CA GLU 252 0.0172 2.1906 1.0600
4058 CA THR 253 0.0156 2.0413 1.0400
4072 CA VAL 254 0.0079 1.2945 0.9900
4088 CA ARG 255 0.0085 1.3522 0.9200
4112 CA ASN 256 0.0124 1.7290 0.8700
4126 CA TYR 257 0.0090 1.3932 0.8300
4147 CA VAL 258 0.0066 1.1601 0.8100
4163 CA MET 259 0.0115 1.6384 0.8000
4180 CA ASN 260 0.0158 2.0528 0.8000
4194 CA LYS 261 0.0129 1.7764 0.8000
4216 CA PRO 262 0.0209 2.5523 0.7900
4230 CA GLN 263 0.0159 2.0688 0.7800
4247 CA PHE 264 0.0117 1.6633 0.7800
4267 CA PRO 265 0.0192 2.3889 0.7800
4281 CA GLY 266 0.0110 1.5891 0.8000
4288 CA VAL 267 0.0086 1.3597 0.8300
4304 CA SER 268 0.0099 1.4799 0.8600
4315 CA PHE 269 0.0051 1.0192 0.8900
4335 CA ASN 270 0.0071 1.2127 0.9100
4349 CA GLU 271 0.0091 1.4033 0.9200
4364 CA LEU 272 0.0049 0.9994 0.9400
4383 CA PHE 273 0.0038 0.8891 0.9700
4403 CA PRO 274 0.0063 1.1379 1.0100
4417 CA ASP 275 0.0083 1.3262 1.0900
4429 CA TRP 276 0.0116 1.6468 1.2200
4453 CA ALA 277 0.0057 1.0788 1.4100
4463 CA PHE 278 0.0048 0.9900 1.6600
4483 CA PRO 279 0.0114 1.6302 1.9700
4497 CA SER 280 0.0167 2.1456 2.2800
4508 CA GLU 281 0.0338 3.8091 2.5500
4523 CA THR 282 0.0266 3.1030 2.6800
4537 CA GLU 283 0.0236 2.8159 2.6300
4552 CA HIS 284 0.0169 2.1628 2.4400
4569 CA ASP 285 0.0097 1.4641 2.1600
4581 CA LYS 286 0.0105 1.5448 1.8800
4603 CA ILE 287 0.0092 1.4124 1.6200
4622 CA LYS 288 0.0055 1.0555 1.3900
4644 CA THR 289 0.0041 0.9225 1.2100
4658 CA SER 290 0.0047 0.9801 1.0600
4669 CA GLN 291 0.0034 0.8533 0.9500
4686 CA ALA 292 0.0022 0.7390 0.8600
4696 CA ARG 293 0.0026 0.7782 0.8100
4720 CA ASP 294 0.0030 0.8179 0.7700
4732 CA LEU 295 0.0016 0.6756 0.7400
4751 CA LEU 296 0.0015 0.6659 0.7100
4770 CA SER 297 0.0021 0.7250 0.7000
4781 CA LYS 298 0.0019 0.7097 0.6900
4803 CA MET 299 0.0011 0.6278 0.6800
4820 CA LEU 300 0.0012 0.6384 0.6900
4839 CA VAL 301 0.0018 0.6968 0.7100
4855 CA ILE 302 0.0017 0.6898 0.7400
4874 CA ASP 303 0.0025 0.7641 0.7700
4886 CA PRO 304 0.0024 0.7515 0.8000
4900 CA GLU 305 0.0056 1.0654 0.8100
4915 CA CYS 306 0.0056 1.0675 0.8100
4926 CA ARG 307 0.0017 0.6898 0.7900
4950 CA ILE 308 0.0018 0.6997 0.7700
4969 CA SER 309 0.0021 0.7267 0.7400
4980 CA VAL 310 0.0016 0.6814 0.7100
4996 CA GLN 311 0.0030 0.8156 0.6900
5013 CA GLU 312 0.0031 0.8242 0.6700
5028 CA ALA 313 0.0018 0.7015 0.6500
5038 CA LEU 314 0.0019 0.7100 0.6500
5057 CA ASN 315 0.0033 0.8456 0.6500
5071 CA HIS 316 0.0027 0.7806 0.6700
5088 CA PRO 317 0.0038 0.8906 0.6900
5102 CA TYR 318 0.0024 0.7579 0.7200
5123 CA ILE 319 0.0023 0.7499 0.7400
5142 CA HIS 320 0.0041 0.9213 0.7500
5159 CA VAL 321 0.0044 0.9493 0.7600
5175 CA TRP 322 0.0041 0.9233 0.7700
5199 CA TYR 323 0.0045 0.9573 0.7800
5220 CA ASP 324 0.0063 1.1373 0.8000
5232 CA PRO 325 0.0095 1.4422 0.8400
5246 CA ALA 326 0.0136 1.8467 0.8900
5256 CA GLU 327 0.0060 1.1060 0.9600
5271 CA ALA 328 0.0040 0.9075 1.0400
5281 CA ASP 329 0.0073 1.2333 1.1300
5293 CA ALA 330 0.0083 1.3275 1.2300
5303 CA PRO 331 0.0163 2.1034 1.3400
5317 CA PRO 332 0.0056 1.0648 1.4400
5331 CA PRO 333 0.0043 0.9364 1.5200
5345 CA GLN 334 0.0063 1.1314 1.5600
5362 CA ILE 335 0.0051 1.0140 1.5700
5381 CA SER 336 0.0040 0.9119 1.5300
5392 CA ASP 337 0.0070 1.1990 1.4700
5404 CA LYS 338 0.0056 1.0698 1.4000
5426 CA GLN 339 0.0079 1.2900 1.3400
5443 CA LEU 340 0.0050 1.0066 1.2800
5462 CA GLU 341 0.0042 0.9299 1.2200
5477 CA GLU 342 0.0071 1.2125 1.1500
5492 CA ARG 343 0.0114 1.6286 1.0600
5516 CA GLU 344 0.0141 1.8902 0.9700
5531 CA HIS 345 0.0077 1.2677 0.8800
5548 CA SER 346 0.0092 1.4138 0.8100
5559 CA ILE 347 0.0068 1.1846 0.7500
5578 CA GLU 348 0.0076 1.2606 0.7100
5593 CA GLN 349 0.0068 1.1842 0.6900
5610 CA TRP 350 0.0041 0.9224 0.6800
5634 CA LYS 351 0.0042 0.9262 0.6900
5656 CA GLU 352 0.0051 1.0175 0.6900
5671 CA LEU 353 0.0036 0.8684 0.7100
5690 CA ILE 354 0.0024 0.7557 0.7200
5709 CA TYR 355 0.0031 0.8258 0.7500
5730 CA LYS 356 0.0046 0.9703 0.7800
5752 CA GLU 357 0.0025 0.7614 0.8200
5767 CA VAL 358 0.0021 0.7277 0.8800
5783 CA MET 359 0.0043 0.9385 0.9600
5800 CA ASP 360 0.0054 1.0501 1.0600
5812 CA TRP 361 0.0034 0.8557 1.1900
5836 CA GLU 362 0.0041 0.9211 1.3600
5851 CA GLU 363 0.0114 1.6326 1.5800
5866 CA ARG 364 0.0127 1.7540 1.8500
5890 CA ASN 365 0.0077 1.2667 2.1800
5904 CA LYS 366 0.0112 1.6085 2.5600
5926 CA ASN 367 0.0093 1.4253 2.9900
5940 CA GLY 368 0.0066 1.1621 3.4700
5947 CA VAL 369 0.0097 1.4659 4.0200
5963 CA LEU 370 0.0174 2.2130 4.6400

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: April 25th, 2023.

Should you encounter any unexpected behaviour, please let us know.

*** ***

B-factor analysis for ID 2402071700381855122

Overall B-factor prediction

B-factors for all residues

Residue-by-residue B-factor prediction for CA atoms

Should you encounter any unexpected behaviour,
please let us know.

* *