Should you encounter any unexpected behaviour,
please let us know.

* 6x3x *

CA distance fluctuations for 2403121503062936047

--- normal mode 27 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
THR 179 0.04 SER 7 -0.14 ASN 33

GLY 47 0.06 ASN 8 -0.12 ARG 327

GLY 47 0.08 MET 9 -0.14 LYS 105

GLY 47 0.05 SER 10 -0.19 GLY 37

GLY 47 0.04 LEU 11 -0.16 GLY 37

GLY 47 0.05 VAL 12 -0.14 LYS 105

GLY 47 0.05 LYS 13 -0.19 GLY 37

ASN 11 0.05 GLU 14 -0.20 GLY 37

ASN 11 0.04 THR 15 -0.14 GLY 37

GLY 47 0.05 VAL 16 -0.16 LYS 105

ASP 10 0.08 ASP 17 -0.16 LYS 105

ASN 11 0.09 ARG 18 -0.13 ALA 109

ASN 11 0.06 LEU 19 -0.14 ARG 327

ASP 10 0.07 LEU 20 -0.14 ALA 109

ASP 10 0.14 LYS 21 -0.14 ALA 109

ASP 10 0.19 GLY 22 -0.13 ALA 109

THR 12 0.09 TYR 23 -0.14 ARG 327

THR 12 0.08 ASP 24 -0.14 ARG 327

GLN 90 0.08 ILE 25 -0.14 ARG 327

ASP 10 0.06 ARG 26 -0.14 ARG 327

ASP 10 0.05 LEU 27 -0.14 ARG 327

ASP 10 0.05 ARG 28 -0.15 ARG 327

LYS 70 0.05 PRO 29 -0.15 ARG 327

LYS 70 0.06 ASP 30 -0.18 ASN 11

ASP 10 0.05 PHE 31 -0.15 THR 12

THR 82 0.06 GLY 32 -0.15 ARG 327

ARG 173 0.05 GLY 33 -0.21 PRO 34

LYS 70 0.06 PRO 34 -0.21 GLY 33

ARG 173 0.07 PRO 35 -0.16 ARG 327

ARG 173 0.07 VAL 36 -0.16 ARG 327

ARG 173 0.08 ALA 37 -0.16 ARG 327

ARG 173 0.08 VAL 38 -0.17 ARG 327

ARG 173 0.09 GLY 39 -0.18 ARG 327

ARG 173 0.09 MET 40 -0.18 ARG 327

THR 216 0.11 ASN 41 -0.19 ARG 327

THR 216 0.09 ILE 42 -0.19 ARG 327

ALA 182 0.09 ASP 43 -0.20 ARG 327

ASP 184 0.09 ILE 44 -0.20 ARG 327

VAL 213 0.10 ALA 45 -0.21 ARG 327

VAL 213 0.10 SER 46 -0.21 ARG 327

VAL 213 0.08 ILE 47 -0.21 ARG 327

VAL 213 0.07 ASP 48 -0.21 ARG 327

VAL 109 0.07 MET 49 -0.21 ARG 327

THR 268 0.08 VAL 50 -0.21 ARG 327

THR 268 0.08 SER 51 -0.19 ARG 327

THR 268 0.08 GLU 52 -0.19 ARG 327

THR 261 0.08 VAL 53 -0.18 PRO 273

VAL 109 0.07 ASN 54 -0.17 ARG 327

ARG 136 0.08 MET 55 -0.18 ARG 327

ARG 136 0.08 ASP 56 -0.18 ARG 327

ASP 184 0.08 TYR 57 -0.19 ARG 327

VAL 108 0.09 THR 58 -0.19 ARG 327

VAL 108 0.08 LEU 59 -0.20 ARG 327

VAL 108 0.08 THR 60 -0.19 ARG 327

THR 48 0.08 MET 61 -0.20 ARG 327

THR 215 0.07 TYR 62 -0.19 ARG 327

ARG 173 0.08 PHE 63 -0.18 ARG 327

SER 217 0.08 GLN 64 -0.18 ARG 327

ARG 173 0.08 GLN 65 -0.17 ARG 327

ARG 173 0.07 ALA 66 -0.17 ARG 327

VAL 38 0.08 TRP 67 -0.16 ARG 327

THR 123 0.08 ARG 68 -0.15 ARG 327

VAL 36 0.06 ASP 69 -0.15 ARG 327

PRO 34 0.06 LYS 70 -0.16 ASP 10

ASP 30 0.05 ARG 71 -0.14 ARG 327

VAL 36 0.04 LEU 72 -0.14 ARG 327

ALA 37 0.05 SER 73 -0.14 ARG 327

ALA 37 0.04 TYR 74 -0.14 ARG 327

ALA 37 0.05 ASN 75 -0.13 ARG 327

GLY 170 0.04 VAL 76 -0.13 ARG 327

GLY 170 0.05 ILE 77 -0.13 ARG 327

GLY 170 0.06 PRO 78 -0.13 ARG 327

GLY 170 0.06 LEU 79 -0.14 ARG 327

GLY 170 0.05 ASN 80 -0.14 ARG 327

ARG 173 0.04 LEU 81 -0.14 ARG 327

GLU 178 0.05 THR 82 -0.15 ARG 327

GLU 178 0.04 LEU 83 -0.15 ARG 327

LEU 52 0.04 ASP 84 -0.15 ARG 327

THR 13 0.05 ASN 85 -0.15 ARG 327

THR 13 0.06 ARG 86 -0.17 ALA 109

ILE 25 0.05 VAL 87 -0.15 ALA 109

ILE 116 0.06 ALA 88 -0.15 ARG 327

ILE 25 0.06 ASP 89 -0.16 ALA 109

ILE 25 0.08 GLN 90 -0.15 ALA 109

ILE 25 0.07 LEU 91 -0.15 ARG 327

ASP 10 0.05 TRP 92 -0.15 ARG 327

VAL 124 0.06 VAL 93 -0.15 ARG 327

THR 172 0.07 PRO 94 -0.16 ARG 327

ALA 91 0.09 ASP 95 -0.16 ARG 327

THR 172 0.08 THR 96 -0.16 ARG 327

THR 172 0.08 TYR 97 -0.16 ARG 327

PHE 65 0.09 PHE 98 -0.17 ARG 327

PHE 65 0.11 LEU 99 -0.16 ARG 327

THR 48 0.13 ASN 100 -0.17 ARG 327

THR 110 0.08 ASP 101 -0.17 ARG 327

VAL 108 0.13 LYS 102 -0.16 ARG 327

VAL 108 0.15 LYS 103 -0.16 ARG 327

THR 110 0.10 SER 104 -0.17 ARG 327

ARG 86 0.09 PHE 105 -0.16 ARG 327

ARG 86 0.09 VAL 106 -0.17 ARG 327

ASP 89 0.09 HIS 107 -0.17 ARG 327

GLN 90 0.09 GLY 108 -0.19 ASP 120

GLN 90 0.08 VAL 109 -0.16 ARG 327

THR 16 0.08 THR 110 -0.16 ARG 327

ARG 17 0.08 VAL 111 -0.15 ARG 327

THR 13 0.08 LYS 112 -0.16 ARG 327

THR 13 0.07 ASN 113 -0.16 ARG 327

TYR 172 0.07 ARG 114 -0.16 ARG 327

ALA 91 0.06 MET 115 -0.16 ARG 327

ALA 88 0.06 ILE 116 -0.16 ARG 327

LEU 125 0.06 ARG 117 -0.15 ARG 327

ARG 173 0.05 LEU 118 -0.15 ARG 327

GLY 39 0.06 HIS 119 -0.15 ARG 327

ALA 37 0.05 PRO 120 -0.14 ARG 327

ALA 37 0.07 ASP 121 -0.14 ARG 327

ARG 68 0.07 GLY 122 -0.14 ARG 327

ALA 37 0.08 THR 123 -0.15 ARG 327

ARG 173 0.06 VAL 124 -0.15 ARG 327

ARG 173 0.06 LEU 125 -0.16 ARG 327

ARG 173 0.06 TYR 126 -0.16 ARG 327

GLY 173 0.07 GLY 127 -0.17 ARG 327

THR 113 0.07 LEU 128 -0.17 ARG 327

TYR 172 0.07 ARG 129 -0.18 ARG 327

ARG 86 0.08 ILE 130 -0.18 ARG 327

THR 110 0.09 THR 131 -0.18 ARG 327

VAL 108 0.10 THR 132 -0.18 ARG 327

VAL 108 0.09 THR 133 -0.18 ARG 327

THR 48 0.10 ALA 134 -0.17 ARG 327

SER 49 0.11 ALA 135 -0.17 ARG 327

ASP 184 0.14 CYS 136 -0.18 ARG 327

SER 186 0.14 MET 137 -0.18 ARG 327

ASP 184 0.11 MET 138 -0.19 ARG 327

ASP 184 0.10 ASP 139 -0.19 LEU 345

THR 261 0.10 LEU 140 -0.20 ARG 327

THR 261 0.11 ARG 141 -0.21 LEU 345

THR 261 0.10 ARG 142 -0.22 ARG 327

THR 261 0.11 TYR 143 -0.22 ARG 327

THR 261 0.10 PRO 144 -0.24 ARG 327

THR 261 0.10 LEU 145 -0.26 ARG 327

ASP 184 0.10 ASP 146 -0.24 ARG 327

ASP 184 0.13 GLU 147 -0.23 ARG 327

ASP 184 0.15 GLN 148 -0.21 ARG 327

ASP 184 0.19 ASN 149 -0.20 ARG 327

ASP 184 0.15 CYS 150 -0.30 THR 151

ASP 184 0.15 THR 151 -0.30 CYS 150

THR 48 0.12 LEU 152 -0.19 ARG 327

VAL 180 0.11 GLU 153 -0.18 ARG 327

ARG 173 0.09 ILE 154 -0.17 ARG 327

ARG 173 0.10 GLU 155 -0.16 ARG 327

THR 172 0.09 SER 156 -0.16 ARG 327

THR 172 0.10 TYR 157 -0.15 ARG 327

THR 172 0.08 GLY 158 -0.14 ARG 327

ARG 173 0.08 TYR 159 -0.15 ARG 327

ARG 173 0.11 THR 160 -0.16 ARG 327

ARG 173 0.11 THR 161 -0.16 ARG 327

ARG 173 0.09 ASP 162 -0.15 ARG 327

ARG 173 0.08 ASP 163 -0.15 ARG 327

ARG 173 0.08 ILE 164 -0.16 ARG 327

ARG 173 0.09 GLU 165 -0.16 ARG 327

ARG 173 0.10 PHE 166 -0.17 ARG 327

ARG 173 0.09 TYR 167 -0.18 ARG 327

ARG 173 0.09 TRP 168 -0.18 ARG 327

ARG 173 0.08 ARG 169 -0.18 ARG 327

ARG 173 0.08 GLY 170 -0.19 ARG 327

ARG 177 0.09 ASP 171 -0.19 ARG 327

ARG 177 0.09 ASP 172 -0.20 ARG 327

THR 216 0.09 ASN 173 -0.20 ARG 327

THR 216 0.11 ALA 174 -0.19 ARG 327

THR 216 0.11 VAL 175 -0.20 ARG 327

THR 215 0.12 THR 176 -0.21 ARG 327

VAL 213 0.11 GLY 177 -0.22 ARG 327

ASP 184 0.11 VAL 178 -0.22 ARG 327

VAL 213 0.13 THR 179 -0.24 ARG 327

VAL 213 0.14 LYS 180 -0.24 ARG 327

VAL 213 0.11 ILE 181 -0.23 ARG 327

VAL 213 0.10 GLU 182 -0.24 ARG 327

THR 268 0.08 LEU 183 -0.24 ARG 327

THR 268 0.09 PRO 184 -0.25 ARG 327

THR 268 0.09 GLN 185 -0.25 ARG 327

SER 187 0.11 PHE 186 -0.24 ARG 327

ASP 184 0.12 SER 187 -0.26 ARG 327

ASP 184 0.13 ILE 188 -0.24 ARG 327

ASP 184 0.13 VAL 189 -0.25 ARG 327

ASP 184 0.13 ASP 190 -0.23 ARG 327

ASP 184 0.13 TYR 191 -0.22 ARG 327

GLU 183 0.12 LYS 192 -0.21 ARG 327

ALA 182 0.11 LEU 193 -0.20 ARG 327

VAL 180 0.12 ILE 194 -0.19 ARG 327

ARG 177 0.11 THR 195 -0.18 ARG 327

THR 195 0.11 LYS 196 -0.18 ARG 327

ARG 173 0.11 LYS 197 -0.17 ARG 327

ARG 173 0.14 VAL 198 -0.16 ARG 327

ARG 173 0.16 VAL 199 -0.17 ASP 184

ARG 173 0.19 PHE 200 -0.19 ASP 184

ARG 173 0.23 SER 201 -0.19 ALA 182

THR 172 0.16 THR 202 -0.14 ALA 182

ARG 173 0.13 GLY 203 -0.15 ARG 327

ARG 173 0.13 SER 204 -0.15 ARG 327

ARG 173 0.12 TYR 205 -0.16 ARG 327

ARG 173 0.11 PRO 206 -0.16 ARG 327

ARG 173 0.11 ARG 207 -0.17 ARG 327

VAL 180 0.10 LEU 208 -0.18 ARG 327

ALA 182 0.12 SER 209 -0.19 ARG 327

ALA 182 0.12 LEU 210 -0.20 ARG 327

ASP 184 0.15 SER 211 -0.20 ARG 327

ASP 184 0.16 PHE 212 -0.22 ARG 327

ASP 184 0.17 LYS 213 -0.23 ARG 327

ASP 184 0.13 LEU 214 -0.23 ARG 327

ASP 184 0.12 LYS 215 -0.25 ARG 327

THR 261 0.09 ARG 216 -0.25 ARG 327

THR 261 0.08 ASN 217 -0.28 ARG 327

LEU 274 0.08 ILE 218 -0.29 ARG 327

LEU 274 0.08 GLY 219 -0.31 ARG 327

LEU 274 0.09 TYR 220 -0.27 ARG 327

LEU 274 0.11 PHE 221 -0.27 ARG 327

LEU 274 0.10 ILE 222 -0.31 ARG 327

LEU 274 0.12 LEU 223 -0.29 ARG 327

LEU 274 0.14 GLN 224 -0.25 ARG 327

LEU 274 0.15 THR 225 -0.25 ARG 327

LEU 274 0.13 TYR 226 -0.29 ARG 327

LEU 274 0.13 MET 227 -0.32 ARG 327

LEU 274 0.18 PRO 228 -0.27 ARG 327

SER 267 0.16 SER 229 -0.26 ARG 327

SER 267 0.14 ILE 230 -0.32 ARG 327

SER 267 0.15 LEU 231 -0.33 ARG 327

SER 267 0.20 ILE 232 -0.25 THR 316

SER 267 0.18 THR 233 -0.26 SER 323

SER 267 0.16 ILE 234 -0.33 SER 323

SER 267 0.20 LEU 235 -0.31 THR 316

SER 267 0.23 SER 236 -0.21 THR 316

VAL 252 0.17 TRP 237 -0.31 SER 323

VAL 252 0.17 VAL 238 -0.30 TYR 319

VAL 252 0.23 SER 239 -0.16 GLY 334

LYS 312 0.20 PHE 240 -0.23 SER 323

LYS 312 0.23 TRP 241 -0.25 SER 323

LYS 312 0.26 ILE 242 -0.12 GLY 334

LYS 312 0.31 ASN 243 -0.11 PHE 240

LYS 312 0.29 TYR 244 -0.10 GLY 334

SER 322 0.42 ASP 245 -0.07 SER 353

SER 322 0.39 ALA 246 -0.08 VAL 312

SER 251 0.31 SER 247 -0.07 VAL 312

PRO 253 0.34 ALA 248 -0.09 VAL 312

PRO 253 0.34 ALA 249 -0.13 GLY 315

PRO 253 0.27 ARG 250 -0.11 GLY 334

PRO 253 0.28 VAL 251 -0.11 VAL 243

PRO 253 0.33 ALA 252 -0.15 GLU 313

PRO 253 0.26 LEU 253 -0.20 GLY 315

PRO 253 0.22 GLY 254 -0.16 THR 316

PRO 253 0.22 ILE 255 -0.20 LEU 240

VAL 257 0.23 THR 256 -0.20 GLU 313

SER 267 0.20 THR 257 -0.21 THR 316

PHE 289 0.18 VAL 258 -0.23 THR 237

VAL 257 0.23 LEU 259 -0.24 THR 237

VAL 257 0.20 THR 260 -0.20 GLU 313

VAL 257 0.17 MET 261 -0.21 PRO 233

THR 261 0.18 THR 262 -0.30 PRO 233

THR 261 0.20 THR 263 -0.24 SER 272

THR 261 0.16 ILE 264 -0.21 PRO 233

THR 261 0.15 ASN 265 -0.24 PRO 233

THR 265 0.17 THR 266 -0.26 GLN 229

THR 268 0.16 HIS 267 -0.21 SER 272

THR 265 0.14 LEU 268 -0.21 GLN 224

THR 261 0.13 ARG 269 -0.20 GLN 229

THR 256 0.14 GLU 270 -0.16 LYS 285

THR 268 0.13 THR 271 -0.18 ARG 327

THR 261 0.11 LEU 272 -0.18 ARG 327

THR 256 0.11 PRO 273 -0.18 VAL 53

THR 268 0.12 LYS 274 -0.20 LEU 345

TYR 277 0.12 ILE 275 -0.22 LEU 345

TYR 277 0.12 PRO 276 -0.28 LEU 345

PRO 276 0.12 TYR 277 -0.27 LEU 345

ALA 254 0.12 VAL 278 -0.24 LEU 345

VAL 257 0.11 LYS 279 -0.21 LEU 345

VAL 257 0.11 ALA 280 -0.22 ARG 327

THR 261 0.13 ILE 281 -0.23 ARG 327

VAL 257 0.13 ASP 282 -0.21 TRP 341

VAL 257 0.13 MET 283 -0.21 SER 323

VAL 257 0.13 TYR 284 -0.24 SER 323

VAL 257 0.15 LEU 285 -0.22 ARG 327

PRO 253 0.14 MET 286 -0.21 LEU 338

PRO 253 0.14 GLY 287 -0.23 SER 323

VAL 258 0.16 CYS 288 -0.24 SER 323

VAL 258 0.18 PHE 289 -0.19 GLY 334

SER 251 0.16 VAL 290 -0.21 GLY 334

PRO 253 0.16 PHE 291 -0.24 SER 323

PRO 253 0.19 VAL 292 -0.20 SER 323

PRO 253 0.18 PHE 293 -0.20 GLY 334

SER 251 0.17 MET 294 -0.19 GLY 334

SER 251 0.18 ALA 295 -0.18 GLY 334

SER 251 0.20 LEU 296 -0.17 GLY 334

SER 251 0.19 LEU 297 -0.20 GLY 334

SER 251 0.19 GLU 298 -0.18 GLY 334

SER 251 0.22 TYR 299 -0.15 GLY 334

SER 251 0.22 ALA 300 -0.15 GLY 334

LYS 312 0.21 LEU 301 -0.17 GLY 334

LYS 312 0.23 VAL 302 -0.14 GLY 334

GLU 250 0.25 ASN 303 -0.12 GLY 334

LYS 312 0.24 TYR 304 -0.14 GLY 334

LYS 312 0.25 ILE 305 -0.15 GLY 334

LYS 312 0.29 PHE 306 -0.12 GLY 334

LYS 312 0.30 PHE 307 -0.09 GLY 334

LYS 312 0.27 SER 308 -0.11 GLY 334

LYS 312 0.28 GLN 309 -0.12 GLY 334

LYS 312 0.30 PRO 310 -0.12 GLY 334

LYS 312 0.28 ALA 311 -0.14 GLY 334

LYS 312 0.25 ARG 312 -0.16 GLY 334

LYS 312 0.26 ALA 313 -0.15 GLY 334

LYS 312 0.25 ALA 314 -0.13 GLY 334

LYS 312 0.22 ALA 315 -0.13 ALA 311

LYS 312 0.22 ILE 316 -0.15 GLY 334

LYS 312 0.22 ASP 317 -0.15 SER 323

LYS 312 0.19 ARG 318 -0.35 SER 323

LYS 312 0.18 TRP 319 -0.33 SER 323

LYS 312 0.18 SER 320 -0.31 SER 323

LYS 312 0.17 ARG 321 -0.46 SER 323

GLU 250 0.13 ILE 322 -0.58 SER 323

SER 251 0.14 PHE 323 -0.45 SER 323

SER 251 0.15 PHE 324 -0.39 SER 323

SER 251 0.13 PRO 325 -0.46 SER 323

SER 251 0.12 VAL 326 -0.47 SER 323

SER 251 0.14 VAL 327 -0.37 SER 323

SER 251 0.14 PHE 328 -0.36 SER 323

SER 251 0.11 SER 329 -0.41 SER 323

SER 251 0.12 PHE 330 -0.37 SER 323

GLY 287 0.14 PHE 331 -0.34 SER 323

SER 267 0.12 ASN 332 -0.34 SER 323

SER 267 0.10 ILE 333 -0.37 GLN 324

SER 251 0.11 VAL 334 -0.33 GLN 324

SER 267 0.11 TYR 335 -0.30 GLN 324

SER 267 0.10 TRP 336 -0.31 GLN 324

SER 267 0.09 LEU 337 -0.32 GLN 324

SER 251 0.10 TYR 338 -0.29 GLN 324

SER 267 0.10 TYR 339 -0.27 GLN 324

SER 267 0.10 VAL 340 -0.29 GLN 324

GLY 22 0.19 ASP 10 -0.16 LYS 70

GLY 22 0.15 ASN 11 -0.18 ASP 30

GLY 22 0.14 THR 12 -0.16 ASP 30

GLY 22 0.12 THR 13 -0.14 ARG 327

ASP 10 0.07 VAL 14 -0.13 ARG 327

ASP 10 0.07 PHE 15 -0.13 ARG 327

ASP 10 0.07 THR 16 -0.13 ARG 327

ASP 10 0.08 ARG 17 -0.12 ARG 327

ASP 10 0.08 ILE 18 -0.12 ARG 327

ASP 10 0.08 LEU 19 -0.12 ARG 327

ASP 10 0.09 ASP 20 -0.11 ARG 327

ASP 10 0.10 ARG 21 -0.11 ARG 327

ASP 10 0.09 LEU 22 -0.11 ARG 327

ASP 10 0.09 LEU 23 -0.10 GLY 22

ASP 10 0.11 ASP 24 -0.12 GLY 22

ASP 17 0.13 GLY 25 -0.10 GLY 22

ASP 17 0.10 TYR 26 -0.10 GLY 22

ASP 17 0.09 ASP 27 -0.10 GLY 22

PRO 115 0.09 ASN 28 -0.10 GLY 22

ALA 109 0.09 ARG 29 -0.10 GLY 22

ALA 109 0.08 LEU 30 -0.08 GLY 22

LYS 117 0.08 ARG 31 -0.08 ARG 327

LYS 117 0.08 PRO 32 -0.08 ARG 327

LYS 117 0.07 GLY 33 -0.08 ARG 327

LYS 117 0.06 LEU 34 -0.07 ARG 327

HIS 267 0.06 GLY 35 -0.06 ARG 327

SER 201 0.06 GLU 36 -0.07 ARG 327

THR 126 0.07 ARG 37 -0.07 ARG 327

SER 201 0.07 VAL 38 -0.07 ARG 327

SER 201 0.07 THR 39 -0.08 ARG 327

SER 201 0.09 GLU 40 -0.08 ARG 327

SER 201 0.10 VAL 41 -0.09 ARG 327

SER 201 0.12 LYS 42 -0.09 ARG 327

SER 201 0.11 THR 43 -0.10 ARG 327

PHE 200 0.13 ASP 44 -0.10 ARG 327

GLU 153 0.10 ILE 45 -0.11 ASN 346

GLU 153 0.11 PHE 46 -0.13 ASN 346

THR 151 0.10 VAL 47 -0.15 ASN 346

THR 151 0.13 THR 48 -0.16 ASN 346

CYS 136 0.12 SER 49 -0.17 ASN 346

MET 137 0.10 PHE 50 -0.17 ASN 346

MET 137 0.10 GLY 51 -0.15 ASN 346

MET 137 0.08 PRO 52 -0.15 ASN 346

PRO 154 0.09 VAL 53 -0.14 VAL 53

ASN 103 0.08 SER 54 -0.17 VAL 53

SER 276 0.09 ASP 55 -0.14 VAL 53

SER 276 0.09 HIS 56 -0.17 VAL 53

ASN 103 0.09 ASP 57 -0.19 GLU 52

ASN 103 0.10 MET 58 -0.17 MET 49

ASN 103 0.11 GLU 59 -0.17 MET 49

LEU 155 0.09 TYR 60 -0.13 MET 49

ARG 136 0.10 THR 61 -0.13 ARG 327

MET 137 0.08 ILE 62 -0.12 ARG 327

ALA 135 0.10 ASP 63 -0.13 ARG 327

LEU 99 0.10 VAL 64 -0.12 ASN 346

LEU 99 0.11 PHE 65 -0.12 ARG 327

GLU 153 0.08 PHE 66 -0.11 ARG 327

GLU 153 0.08 ARG 67 -0.11 ARG 327

VAL 41 0.08 GLN 68 -0.11 ARG 327

SER 201 0.08 SER 69 -0.12 THR 126

SER 201 0.07 TRP 70 -0.10 ARG 327

THR 126 0.09 LYS 71 -0.10 ARG 327

THR 126 0.09 ASP 72 -0.09 ARG 327

SER 7 0.09 GLU 73 -0.10 ARG 327

SER 10 0.10 ARG 74 -0.09 ARG 327

SER 10 0.07 LEU 75 -0.10 ARG 327

SER 10 0.08 LYS 76 -0.11 ARG 327

ASP 10 0.08 PHE 77 -0.12 ARG 327

ASP 10 0.08 LYS 78 -0.12 ARG 327

ASP 10 0.07 GLY 79 -0.13 ARG 327

ASP 10 0.07 PRO 80 -0.14 ARG 327

ASP 10 0.06 MET 81 -0.14 ARG 327

ASP 10 0.06 THR 82 -0.13 ARG 327

ASP 10 0.06 VAL 83 -0.13 ARG 327

ASP 10 0.06 LEU 84 -0.13 ARG 327

ASP 10 0.06 ARG 85 -0.14 ARG 327

ASP 10 0.06 LEU 86 -0.13 ARG 327

ASP 10 0.06 ASN 87 -0.14 ARG 327

ALA 91 0.10 ASN 88 -0.14 PHE 105

ASP 10 0.07 LEU 89 -0.13 PHE 105

ASP 10 0.07 MET 90 -0.15 ALA 91

PRO 115 0.11 ALA 91 -0.15 MET 90

PRO 115 0.10 SER 92 -0.12 GLY 22

VAL 106 0.08 LYS 93 -0.13 GLY 22

LYS 117 0.08 ILE 94 -0.10 GLY 22

LYS 117 0.08 TRP 95 -0.09 ARG 327

LYS 117 0.10 THR 96 -0.10 VAL 111

ALA 109 0.09 PRO 97 -0.09 ARG 327

ALA 109 0.11 ASP 98 -0.10 PHE 105

ALA 109 0.11 THR 99 -0.10 PHE 105

LYS 102 0.07 PHE 100 -0.13 PHE 105

GLU 138 0.08 PHE 101 -0.12 ASP 184

GLU 138 0.09 HIS 102 -0.13 ASP 184

GLU 138 0.15 ASN 103 -0.15 ALA 45

GLU 59 0.09 GLY 104 -0.14 THR 133

ASP 57 0.09 LYS 105 -0.18 THR 133

VAL 109 0.10 LYS 106 -0.19 THR 133

VAL 109 0.11 SER 107 -0.14 THR 133

LYS 103 0.15 VAL 108 -0.33 ALA 109

THR 110 0.16 ALA 109 -0.33 VAL 108

THR 99 0.09 HIS 110 -0.15 LYS 103

ALA 91 0.08 ASN 111 -0.14 ARG 327

MET 61 0.08 MET 112 -0.16 ARG 327

PHE 63 0.07 THR 113 -0.16 ARG 327

ALA 91 0.09 MET 114 -0.15 ARG 327

ALA 91 0.11 PRO 115 -0.14 ARG 327

ALA 91 0.09 ASN 116 -0.14 ARG 327

ALA 91 0.11 LYS 117 -0.13 ARG 327

TYR 157 0.07 LEU 118 -0.13 ARG 327

ASP 72 0.06 LEU 119 -0.13 ARG 327

ASP 72 0.06 ARG 120 -0.13 ARG 327

ASP 72 0.07 ILE 121 -0.12 ARG 327

ASP 10 0.06 THR 122 -0.12 ARG 327

ASP 10 0.06 GLU 123 -0.12 ARG 327

SER 7 0.07 ASP 124 -0.11 ARG 327

SER 7 0.08 GLY 125 -0.11 ARG 327

ASP 72 0.09 THR 126 -0.12 SER 69

THR 160 0.06 LEU 127 -0.11 THR 126

TYR 157 0.07 LEU 128 -0.11 ARG 327

LYS 117 0.10 TYR 129 -0.12 THR 110

LYS 117 0.09 THR 130 -0.12 ARG 327

ASN 116 0.07 MET 131 -0.12 ARG 327

THR 132 0.08 ARG 132 -0.13 ARG 327

THR 99 0.09 LEU 133 -0.13 LYS 103

THR 110 0.10 THR 134 -0.14 THR 133

THR 110 0.12 VAL 135 -0.16 THR 133

THR 61 0.10 ARG 136 -0.17 THR 133

THR 110 0.07 ALA 137 -0.17 ASP 48

ASN 103 0.15 GLU 138 -0.18 ASP 48

SER 205 0.10 CYS 139 -0.14 CYS 153

SER 205 0.12 PRO 140 -0.14 GLU 182

SER 205 0.10 MET 141 -0.12 ASP 184

SER 205 0.10 HIS 142 -0.11 ASP 184

SER 206 0.09 LEU 143 -0.11 GLU 313

ARG 347 0.19 GLU 144 -0.12 GLU 313

ILE 333 0.10 ASP 145 -0.13 ALA 285

ILE 333 0.09 PHE 146 -0.12 THR 266

ILE 333 0.09 PRO 147 -0.13 THR 266

ILE 333 0.09 MET 148 -0.22 ARG 347

ILE 333 0.08 ASP 149 -0.17 ARG 347

SER 205 0.07 ALA 150 -0.21 ARG 347

VAL 203 0.08 HIS 151 -0.12 ARG 347

PRO 154 0.09 ALA 152 -0.12 ASP 184

PRO 154 0.13 CYS 153 -0.14 ILE 181

CYS 153 0.13 PRO 154 -0.15 LYS 180

TYR 60 0.09 LEU 155 -0.14 SER 46

TYR 60 0.08 LYS 156 -0.13 ALA 45

VAL 135 0.08 PHE 157 -0.12 ASP 184

VAL 135 0.07 GLY 158 -0.11 ASP 184

THR 132 0.07 SER 159 -0.10 ASP 184

HIS 267 0.07 TYR 160 -0.11 THR 113

THR 82 0.10 ALA 161 -0.09 THR 113

THR 82 0.07 TYR 162 -0.08 ASP 184

TYR 210 0.08 THR 163 -0.09 GLU 183

SER 201 0.06 ARG 164 -0.09 ASP 184

SER 201 0.06 ALA 165 -0.08 GLU 183

LYS 117 0.06 GLU 166 -0.07 GLU 183

SER 201 0.07 VAL 167 -0.08 ASP 184

SER 201 0.08 VAL 168 -0.09 ASP 184

SER 201 0.09 TYR 169 -0.10 ASP 184

SER 201 0.11 GLU 170 -0.10 ASP 184

SER 201 0.14 TRP 171 -0.10 ASP 184

SER 201 0.21 THR 172 -0.09 ARG 327

SER 201 0.23 ARG 173 -0.11 ARG 347

SER 201 0.16 GLU 174 -0.12 ARG 347

SER 201 0.12 PRO 175 -0.11 ASP 184

VAL 199 0.11 ALA 176 -0.15 ARG 347

PHE 200 0.14 ARG 177 -0.16 ARG 347

PHE 200 0.15 SER 178 -0.12 ARG 347

SER 211 0.10 VAL 179 -0.13 ARG 347

SER 211 0.12 VAL 180 -0.17 ASN 346

LYS 213 0.11 VAL 181 -0.18 ASN 346

SER 211 0.14 ALA 182 -0.19 ASN 346

ASN 149 0.16 GLU 183 -0.23 ASN 346

ASN 149 0.19 ASP 184 -0.22 ASN 346

ASN 149 0.15 GLY 185 -0.19 ASN 346

MET 137 0.14 SER 186 -0.21 ASN 346

MET 137 0.13 ARG 187 -0.19 ASN 346

PRO 154 0.08 LEU 188 -0.21 ASN 346

THR 256 0.08 ASN 189 -0.22 LEU 345

TYR 277 0.11 GLN 190 -0.22 LEU 345

TYR 277 0.09 TYR 191 -0.24 ASN 346

TYR 338 0.10 ASP 192 -0.29 ASN 346

TYR 338 0.09 LEU 193 -0.25 ARG 347

TYR 338 0.10 LEU 194 -0.29 ARG 347

TYR 338 0.09 GLY 195 -0.23 ARG 347

ASN 149 0.09 GLN 196 -0.17 ARG 347

LYS 213 0.08 THR 197 -0.13 ARG 347

LYS 213 0.08 VAL 198 -0.13 LYS 180

LYS 213 0.08 ASP 199 -0.12 GLY 177

LYS 213 0.07 SER 200 -0.11 ASP 184

LYS 213 0.07 GLY 201 -0.11 ASP 184

LYS 213 0.07 ILE 202 -0.11 ASP 184

PRO 140 0.10 VAL 203 -0.12 THR 176

PRO 140 0.10 GLN 204 -0.12 ARG 169

PRO 140 0.12 SER 205 -0.15 ASN 41

LYS 180 0.16 SER 206 -0.17 ARG 169

LYS 180 0.11 THR 207 -0.12 ALA 66

PRO 140 0.08 GLY 208 -0.10 GLU 183

PRO 140 0.07 GLU 209 -0.10 GLU 183

THR 163 0.08 TYR 210 -0.11 ASP 184

LYS 213 0.06 VAL 211 -0.11 ASP 184

LYS 213 0.07 VAL 212 -0.12 ASP 184

LYS 213 0.07 MET 213 -0.12 ASP 184

ASN 149 0.08 THR 214 -0.13 GLY 177

ASN 149 0.09 THR 215 -0.13 ASP 184

PHE 217 0.19 HIS 216 -0.15 LYS 180

HIS 216 0.19 PHE 217 -0.14 ARG 347

HIS 216 0.10 HIS 218 -0.20 ARG 347

TYR 338 0.07 LEU 219 -0.23 ARG 347

TYR 338 0.07 LYS 220 -0.32 ARG 347

TYR 338 0.07 ARG 221 -0.26 ARG 347

SER 251 0.08 LYS 222 -0.33 LEU 345

SER 251 0.09 ILE 223 -0.36 LEU 345

ILE 228 0.13 GLY 224 -0.32 LEU 345

LEU 269 0.14 TYR 225 -0.24 LEU 345

LEU 269 0.11 PHE 226 -0.19 LEU 345

GLY 224 0.12 VAL 227 -0.24 TRP 341

GLY 224 0.13 ILE 228 -0.20 THR 266

LEU 269 0.15 GLN 229 -0.26 THR 266

MET 266 0.13 THR 230 -0.25 THR 266

PRO 325 0.10 TYR 231 -0.20 THR 266

LEU 235 0.10 LEU 232 -0.20 THR 262

THR 262 0.14 PRO 233 -0.30 THR 262

LEU 235 0.13 CYS 234 -0.25 THR 262

PRO 325 0.11 ILE 235 -0.20 THR 262

SER 251 0.10 MET 236 -0.23 THR 262

VAL 238 0.12 THR 237 -0.24 LEU 259

ILE 322 0.13 VAL 238 -0.17 LEU 259

ILE 322 0.13 ILE 239 -0.16 VAL 258

SER 251 0.13 LEU 240 -0.20 ILE 255

ILE 242 0.15 SER 241 -0.16 ILE 255

ILE 322 0.15 GLN 242 -0.12 ILE 255

SER 251 0.14 VAL 243 -0.13 ILE 255

SER 251 0.16 SER 244 -0.10 ILE 270

LYS 312 0.17 PHE 245 -0.09 LEU 274

LYS 312 0.18 TRP 246 -0.09 ARG 326

LYS 312 0.20 LEU 247 -0.07 VAL 302

SER 322 0.26 ASN 248 -0.05 VAL 302

SER 322 0.29 ARG 249 -0.04 VAL 302

SER 322 0.37 GLU 250 -0.03 VAL 302

SER 322 0.34 SER 251 -0.04 VAL 302

ALA 246 0.33 VAL 252 -0.06 SER 267

SER 251 0.29 PRO 253 -0.10 SER 267

SER 251 0.24 ALA 254 -0.08 SER 267

SER 322 0.20 ARG 255 -0.08 ILE 270

ALA 249 0.21 THR 256 -0.11 SER 267

ALA 249 0.18 VAL 257 -0.14 SER 267

PHE 293 0.15 PHE 258 -0.13 ILE 270

SER 322 0.14 GLY 259 -0.13 THR 271

SER 322 0.13 VAL 260 -0.16 THR 271

PHE 289 0.14 THR 261 -0.20 THR 271

PRO 233 0.14 THR 262 -0.17 LEU 274

LEU 253 0.14 VAL 263 -0.17 LEU 274

THR 256 0.15 LEU 264 -0.22 LEU 274

GLN 229 0.13 THR 265 -0.23 LEU 274

THR 230 0.13 MET 266 -0.19 LEU 274

THR 256 0.11 THR 267 -0.20 LEU 274

LYS 274 0.12 THR 268 -0.24 LEU 274

GLN 229 0.15 LEU 269 -0.23 THR 263

TYR 225 0.09 SER 270 -0.18 THR 278

ILE 232 0.08 ILE 271 -0.23 THR 278

LYS 274 0.10 SER 272 -0.24 THR 278

LYS 274 0.09 ALA 273 -0.22 THR 266

SER 206 0.08 ARG 274 -0.18 THR 278

THR 131 0.08 ASN 275 -0.21 ILE 282

HIS 56 0.09 SER 276 -0.19 HIS 267

SER 206 0.09 LEU 277 -0.16 LYS 285

SER 206 0.10 PRO 278 -0.16 ILE 282

ASP 48 0.11 LYS 279 -0.16 ILE 282

SER 206 0.10 VAL 280 -0.14 ILE 282

PRO 184 0.13 ALA 281 -0.14 THR 278

THR 343 0.14 TYR 282 -0.13 THR 278

TRP 336 0.15 ALA 283 -0.13 THR 278

ILE 333 0.13 THR 284 -0.13 THR 281

ILE 333 0.14 ALA 285 -0.13 ASP 145

ILE 333 0.13 MET 286 -0.15 THR 266

LEU 223 0.17 ASP 287 -0.14 THR 278

ILE 333 0.19 TRP 288 -0.13 GLU 313

ILE 333 0.16 PHE 289 -0.15 THR 266

SER 329 0.14 ILE 290 -0.14 THR 263

LEU 231 0.19 ALA 291 -0.13 LEU 274

SER 329 0.20 VAL 292 -0.12 LEU 274

SER 329 0.16 CYS 293 -0.14 LEU 259

LEU 235 0.18 TYR 294 -0.14 LEU 274

ILE 234 0.23 ALA 295 -0.12 LEU 274

PRO 325 0.20 PHE 296 -0.13 LEU 274

LEU 235 0.18 VAL 297 -0.14 LEU 274

PRO 325 0.18 PHE 298 -0.15 LEU 274

ILE 322 0.20 SER 299 -0.13 LEU 274

ILE 322 0.17 ALA 300 -0.13 LEU 274

VAL 238 0.20 LEU 301 -0.12 LEU 274

TRP 241 0.23 ILE 302 -0.11 LEU 274

ILE 322 0.21 GLU 303 -0.10 LEU 274

ILE 242 0.21 PHE 304 -0.10 VAL 307

TRP 241 0.32 ALA 305 -0.08 LEU 274

TRP 241 0.26 THR 306 -0.14 PHE 310

SER 322 0.24 VAL 307 -0.10 PHE 304

ASN 243 0.29 ASN 308 -0.05 LEU 274

ASN 243 0.33 TYR 309 -0.09 THR 306

SER 322 0.30 PHE 310 -0.14 THR 306

SER 322 0.35 THR 311 -0.07 THR 306

SER 322 0.42 LYS 312 -0.05 THR 306

SER 322 0.38 SER 313 -0.07 THR 306

SER 322 0.34 GLN 314 -0.08 THR 306

SER 322 0.35 PRO 315 -0.08 ALA 316

SER 322 0.29 ALA 316 -0.08 PRO 315

SER 322 0.25 ARG 317 -0.09 ALA 295

SER 322 0.27 ALA 318 -0.09 GLU 303

SER 322 0.25 ALA 319 -0.06 ALA 295

SER 322 0.21 LYS 320 -0.08 PHE 296

ILE 322 0.21 ILE 321 -0.10 PHE 296

LYS 312 0.19 ASP 322 -0.07 LEU 274

LYS 312 0.17 ARG 323 -0.07 SER 325

ILE 322 0.20 LEU 324 -0.21 SER 325

ILE 322 0.22 SER 325 -0.21 LEU 324

ILE 322 0.18 ARG 326 -0.09 SER 301

ILE 322 0.18 ILE 327 -0.12 TYR 304

ILE 322 0.22 ALA 328 -0.10 LEU 324

ILE 322 0.20 PHE 329 -0.11 VAL 258

ILE 322 0.17 PRO 330 -0.15 LEU 297

ILE 322 0.19 LEU 331 -0.15 ILE 335

VAL 326 0.21 LEU 332 -0.13 PHE 336

SER 329 0.19 PHE 333 -0.15 THR 262

SER 329 0.20 GLY 334 -0.21 VAL 290

SER 329 0.24 ILE 335 -0.18 VAL 290

SER 329 0.25 PHE 336 -0.14 MET 286

ILE 333 0.19 ASN 337 -0.19 MET 286

ILE 333 0.21 LEU 338 -0.21 VAL 278

ILE 333 0.25 VAL 339 -0.17 VAL 278

ILE 333 0.23 TYR 340 -0.18 ILE 223

ILE 333 0.19 TRP 341 -0.26 GLY 224

ILE 333 0.21 ALA 342 -0.25 GLY 224

ILE 333 0.23 THR 343 -0.21 ILE 223

ILE 333 0.19 TYR 344 -0.27 ILE 223

ILE 333 0.16 LEU 345 -0.36 ILE 223

ILE 333 0.18 ASN 346 -0.30 LYS 222

GLU 144 0.19 ARG 347 -0.32 LYS 220

GLU 73 0.09 SER 7 -0.07 ARG 327

GLU 73 0.08 ASN 8 -0.06 ARG 327

GLU 73 0.09 MET 9 -0.07 ARG 327

ARG 74 0.10 SER 10 -0.07 ARG 327

ASP 10 0.08 LEU 11 -0.06 ARG 327

ASP 10 0.07 VAL 12 -0.06 ARG 327

GLY 25 0.09 LYS 13 -0.07 LYS 21

GLY 25 0.11 GLU 14 -0.07 GLU 14

ASP 10 0.10 THR 15 -0.07 GLY 25

ASP 10 0.09 VAL 16 -0.08 LYS 21

GLY 25 0.13 ASP 17 -0.08 GLY 25

ASP 10 0.12 ARG 18 -0.07 GLY 25

ASP 10 0.12 LEU 19 -0.08 GLY 25

ASP 10 0.11 LEU 20 -0.08 GLY 25

ASP 10 0.12 LYS 21 -0.09 GLY 25

ASP 10 0.13 GLY 22 -0.09 GLY 25

ASP 10 0.11 TYR 23 -0.09 GLY 25

GLY 108 0.09 ASP 24 -0.10 GLY 25

GLY 108 0.09 ILE 25 -0.10 GLY 25

TRP 123 0.08 ARG 26 -0.11 GLY 25

THR 271 0.07 LEU 27 -0.10 GLY 25

THR 271 0.07 ARG 28 -0.09 GLY 25

THR 271 0.07 PRO 29 -0.08 GLY 25

THR 271 0.06 ASP 30 -0.08 GLY 25

THR 271 0.06 PHE 31 -0.09 GLY 25

THR 271 0.06 GLY 32 -0.08 GLY 25

THR 271 0.06 GLY 33 -0.08 GLY 25

THR 271 0.06 PRO 34 -0.08 SER 206

THR 271 0.06 PRO 35 -0.09 ARG 173

THR 271 0.06 VAL 36 -0.10 SER 206

LYS 70 0.08 ALA 37 -0.11 SER 206

LYS 70 0.08 VAL 38 -0.12 SER 206

THR 123 0.10 GLY 39 -0.15 SER 206

THR 123 0.09 MET 40 -0.14 SER 206

THR 123 0.09 ASN 41 -0.15 SER 205

THR 271 0.08 ILE 42 -0.13 ASP 184

SER 206 0.11 ASP 43 -0.14 ASP 184

SER 206 0.09 ILE 44 -0.15 ASP 184

SER 206 0.11 ALA 45 -0.15 ASN 103

LEU 183 0.10 SER 46 -0.15 PRO 154

HIS 267 0.10 ILE 47 -0.16 ASP 184

HIS 267 0.12 ASP 48 -0.18 GLU 138

THR 271 0.14 MET 49 -0.19 ASP 57

THR 271 0.15 VAL 50 -0.16 ASP 57

THR 271 0.20 SER 51 -0.17 ASP 57

LEU 272 0.17 GLU 52 -0.19 ASP 57

PRO 273 0.28 VAL 53 -0.22 LYS 285

PRO 273 0.16 ASN 54 -0.18 LYS 285

THR 271 0.10 MET 55 -0.18 PRO 52

THR 271 0.12 ASP 56 -0.15 GLY 51

THR 271 0.13 TYR 57 -0.16 ASP 184

THR 271 0.13 THR 58 -0.18 LYS 105

THR 271 0.11 LEU 59 -0.16 LYS 105

MET 61 0.15 THR 60 -0.14 LYS 105

THR 60 0.15 MET 61 -0.13 ASP 184

HIS 267 0.09 TYR 62 -0.11 ASP 184

THR 271 0.09 PHE 63 -0.11 ALA 182

THR 271 0.08 GLN 64 -0.11 SER 205

THR 271 0.08 GLN 65 -0.11 SER 206

THR 123 0.10 ALA 66 -0.12 SER 206

ARG 169 0.09 TRP 67 -0.10 SER 206

LYS 70 0.10 ARG 68 -0.09 SER 206

LYS 70 0.15 ASP 69 -0.11 THR 123

ASP 69 0.15 LYS 70 -0.08 GLY 25

ASP 10 0.09 ARG 71 -0.08 GLY 25

ARG 169 0.08 LEU 72 -0.08 GLY 25

ARG 169 0.09 SER 73 -0.08 GLY 25

ARG 169 0.09 TYR 74 -0.07 GLY 25

GLY 170 0.09 ASN 75 -0.07 GLY 25

GLY 170 0.08 VAL 76 -0.07 GLY 25

GLY 170 0.09 ILE 77 -0.06 GLY 25

GLY 170 0.10 PRO 78 -0.06 GLY 25

GLY 170 0.08 LEU 79 -0.06 GLY 25

GLY 170 0.09 ASN 80 -0.07 GLY 25

HIS 267 0.07 LEU 81 -0.07 LYS 21

ALA 161 0.10 THR 82 -0.07 LYS 21

ALA 109 0.08 LEU 83 -0.08 LYS 21

ALA 109 0.10 ASP 84 -0.09 GLY 22

ALA 109 0.10 ASN 85 -0.10 LYS 21

PHE 105 0.09 ARG 86 -0.12 LYS 21

VAL 106 0.08 VAL 87 -0.11 LYS 21

HIS 267 0.09 ALA 88 -0.11 LYS 21

GLY 108 0.09 ASP 89 -0.13 LYS 21

GLY 108 0.09 GLN 90 -0.11 LYS 21

THR 271 0.08 LEU 91 -0.09 LYS 21

THR 271 0.08 TRP 92 -0.09 ASP 17

THR 271 0.08 VAL 93 -0.10 LYS 21

THR 271 0.08 PRO 94 -0.09 ASP 17

THR 271 0.08 ASP 95 -0.10 ASP 17

THR 271 0.09 THR 96 -0.10 ASP 17

THR 271 0.09 TYR 97 -0.10 VAL 180

THR 271 0.09 PHE 98 -0.13 THR 48

THR 271 0.09 LEU 99 -0.19 THR 48

THR 271 0.10 ASN 100 -0.21 THR 48

THR 271 0.12 ASP 101 -0.15 THR 48

THR 271 0.13 LYS 102 -0.15 ASP 63

THR 271 0.13 LYS 103 -0.16 LYS 106

THR 271 0.12 SER 104 -0.15 LYS 106

THR 271 0.11 PHE 105 -0.21 HIS 107

HIS 267 0.10 VAL 106 -0.20 PHE 105

HIS 267 0.10 HIS 107 -0.21 PHE 105

LYS 103 0.10 GLY 108 -0.15 PHE 105

LYS 103 0.12 VAL 109 -0.12 ASN 88

ALA 109 0.16 THR 110 -0.12 LEU 119

ALA 109 0.13 VAL 111 -0.12 MET 90

LYS 103 0.09 LYS 112 -0.11 GLY 22

HIS 267 0.09 ASN 113 -0.11 MET 112

HIS 267 0.08 ARG 114 -0.11 THR 113

HIS 267 0.08 MET 115 -0.09 LYS 21

HIS 267 0.08 ILE 116 -0.09 LYS 21

HIS 267 0.08 ARG 117 -0.08 LYS 21

ARG 169 0.08 LEU 118 -0.07 GLY 25

ARG 169 0.10 HIS 119 -0.07 GLY 25

ARG 169 0.10 PRO 120 -0.07 GLY 25

ARG 169 0.12 ASP 121 -0.07 GLY 25

ARG 169 0.12 GLY 122 -0.08 GLY 25

ARG 169 0.14 THR 123 -0.11 ASP 69

GLY 122 0.08 VAL 124 -0.08 THR 207

LEU 118 0.07 LEU 125 -0.11 THR 207

THR 271 0.08 TYR 126 -0.08 LYS 21

HIS 267 0.08 GLY 127 -0.09 ALA 161

HIS 267 0.09 LEU 128 -0.10 THR 113

HIS 267 0.10 ARG 129 -0.11 PHE 100

THR 271 0.11 ILE 130 -0.11 THR 48

THR 271 0.12 THR 131 -0.12 ASP 184

THR 271 0.14 THR 132 -0.15 THR 48

THR 271 0.12 THR 133 -0.19 LYS 106

THR 271 0.11 ALA 134 -0.15 LYS 105

THR 271 0.11 ALA 135 -0.20 SER 49

THR 271 0.09 CYS 136 -0.26 ASP 184

LEU 272 0.09 MET 137 -0.29 SER 186

LEU 272 0.07 MET 138 -0.23 ASP 184

VAL 339 0.05 ASP 139 -0.21 ASP 192

ALA 280 0.07 LEU 140 -0.19 GLN 190

VAL 339 0.06 ARG 141 -0.20 ASP 192

VAL 339 0.09 ARG 142 -0.19 ASP 192

VAL 339 0.08 TYR 143 -0.19 ILE 282

THR 343 0.09 PRO 144 -0.18 ILE 282

THR 343 0.12 LEU 145 -0.16 ILE 282

THR 343 0.10 ASP 146 -0.18 ASP 184

THR 343 0.09 GLU 147 -0.21 ASP 184

THR 343 0.06 GLN 148 -0.25 ASP 184

THR 343 0.05 ASN 149 -0.29 ASP 184

THR 151 0.13 CYS 150 -0.25 ASP 184

CYS 150 0.13 THR 151 -0.25 ASP 184

THR 271 0.09 LEU 152 -0.19 ASP 184

THR 271 0.08 GLU 153 -0.19 ALA 182

THR 271 0.08 ILE 154 -0.15 ALA 182

THR 271 0.08 GLU 155 -0.14 VAL 180

THR 271 0.07 SER 156 -0.11 ARG 173

THR 271 0.07 TYR 157 -0.11 ASP 17

THR 271 0.07 GLY 158 -0.10 ASP 17

THR 271 0.06 TYR 159 -0.10 ARG 173

THR 271 0.07 THR 160 -0.13 ARG 173

THR 271 0.06 THR 161 -0.13 ARG 173

THR 271 0.06 ASP 162 -0.11 ARG 173

THR 271 0.06 ASP 163 -0.10 ARG 173

THR 271 0.06 ILE 164 -0.10 ARG 173

THR 271 0.06 GLU 165 -0.11 ARG 173

LYS 70 0.06 PHE 166 -0.11 SER 206

THR 123 0.07 TYR 167 -0.13 SER 206

THR 123 0.09 TRP 168 -0.14 SER 206

THR 123 0.14 ARG 169 -0.17 SER 206

THR 123 0.12 GLY 170 -0.14 SER 206

THR 123 0.10 ASP 171 -0.14 GLU 183

THR 123 0.09 ASP 172 -0.14 GLU 183

THR 123 0.10 ASN 173 -0.13 GLU 183

THR 123 0.11 ALA 174 -0.14 SER 205

THR 123 0.09 VAL 175 -0.14 ASP 184

VAL 178 0.08 THR 176 -0.13 ASP 184

SER 206 0.13 GLY 177 -0.14 ASP 184

SER 206 0.11 VAL 178 -0.16 ASP 184

SER 206 0.11 THR 179 -0.15 ASP 184

SER 206 0.16 LYS 180 -0.15 HIS 216

SER 206 0.14 ILE 181 -0.15 ASP 184

SER 206 0.13 GLU 182 -0.14 ASP 184

SER 206 0.11 LEU 183 -0.14 ASP 184

ALA 281 0.13 PRO 184 -0.13 MET 58

ALA 281 0.10 GLN 185 -0.14 ILE 282

THR 343 0.08 PHE 186 -0.16 ASP 184

THR 343 0.09 SER 187 -0.17 ASP 184

THR 343 0.08 ILE 188 -0.18 ASP 184

THR 343 0.08 VAL 189 -0.17 ASP 184

THR 343 0.07 ASP 190 -0.18 ASP 184

THR 123 0.07 TYR 191 -0.19 ASP 184

THR 123 0.07 LYS 192 -0.19 GLU 183

THR 123 0.07 LEU 193 -0.18 GLU 183

ASP 121 0.06 ILE 194 -0.19 GLU 183

LYS 70 0.05 THR 195 -0.16 GLU 183

THR 271 0.06 LYS 196 -0.14 ARG 177

THR 271 0.06 LYS 197 -0.15 ARG 177

THR 271 0.06 VAL 198 -0.18 ARG 177

ASP 184 0.06 VAL 199 -0.20 ARG 177

ASP 184 0.10 PHE 200 -0.23 ARG 173

ASP 184 0.12 SER 201 -0.28 ARG 173

THR 48 0.09 THR 202 -0.19 THR 172

ASP 184 0.06 GLY 203 -0.17 ARG 173

THR 271 0.06 SER 204 -0.16 ARG 173

THR 271 0.06 TYR 205 -0.15 ARG 173

THR 271 0.06 PRO 206 -0.13 ARG 177

THR 271 0.07 ARG 207 -0.15 VAL 180

THR 271 0.06 LEU 208 -0.16 ALA 182

THR 271 0.06 SER 209 -0.20 GLU 183

THR 123 0.07 LEU 210 -0.20 ASP 184

CYS 150 0.08 SER 211 -0.24 ASP 184

THR 123 0.06 PHE 212 -0.22 ASP 184

THR 343 0.06 LYS 213 -0.22 ASP 184

THR 343 0.07 LEU 214 -0.21 ASP 184

THR 343 0.09 LYS 215 -0.18 ASP 184

THR 343 0.09 ARG 216 -0.16 ASP 184

THR 343 0.12 ASN 217 -0.14 ILE 282

THR 343 0.14 ILE 218 -0.15 THR 278

THR 343 0.16 GLY 219 -0.14 THR 278

THR 343 0.11 TYR 220 -0.16 THR 278

THR 343 0.11 PHE 221 -0.17 THR 278

THR 343 0.15 ILE 222 -0.17 THR 275

ASP 287 0.17 LEU 223 -0.16 THR 275

MET 49 0.09 GLN 224 -0.18 THR 278

VAL 339 0.10 THR 225 -0.20 THR 275

VAL 339 0.14 TYR 226 -0.18 THR 275

ALA 291 0.17 MET 227 -0.16 THR 275

ALA 291 0.15 PRO 228 -0.18 THR 275

ALA 291 0.12 SER 229 -0.19 THR 275

PHE 336 0.16 ILE 230 -0.16 THR 275

ALA 295 0.21 LEU 231 -0.15 THR 275

ALA 295 0.15 ILE 232 -0.16 THR 275

ALA 295 0.16 THR 233 -0.15 THR 275

ALA 295 0.23 ILE 234 -0.12 THR 275

ALA 295 0.20 LEU 235 -0.11 THR 271

SER 322 0.17 SER 236 -0.13 THR 271

SER 322 0.20 TRP 237 -0.10 THR 275

SER 322 0.22 VAL 238 -0.07 THR 271

SER 322 0.24 SER 239 -0.08 SER 267

SER 322 0.26 PHE 240 -0.07 LEU 250

ALA 305 0.32 TRP 241 -0.06 SER 267

ALA 305 0.31 ILE 242 -0.06 SER 267

SER 322 0.35 ASN 243 -0.04 SER 267

SER 322 0.36 TYR 244 -0.04 SER 267

SER 322 0.43 ASP 245 -0.02 ALA 342

SER 322 0.41 ALA 246 -0.02 SER 267

SER 322 0.37 SER 247 -0.05 SER 267

ALA 254 0.35 ALA 248 -0.08 SER 267

SER 322 0.28 ALA 249 -0.09 SER 267

SER 322 0.28 ARG 250 -0.10 SER 267

SER 322 0.25 VAL 251 -0.12 SER 267

SER 322 0.20 ALA 252 -0.18 SER 267

SER 322 0.19 LEU 253 -0.14 SER 267

SER 322 0.19 GLY 254 -0.13 SER 267

LEU 240 0.19 ILE 255 -0.18 LEU 268

LEU 264 0.15 THR 256 -0.22 THR 271

SER 322 0.12 THR 257 -0.18 THR 271

MET 236 0.14 VAL 258 -0.19 THR 271

PRO 233 0.16 LEU 259 -0.26 THR 271

GLU 270 0.13 THR 260 -0.24 THR 275

LEU 345 0.10 MET 261 -0.23 THR 275

PRO 233 0.15 THR 262 -0.29 THR 275

PRO 233 0.13 THR 263 -0.33 THR 275

MET 49 0.10 ILE 264 -0.27 THR 275

VAL 53 0.11 ASN 265 -0.27 THR 275

VAL 53 0.12 THR 266 -0.33 THR 268

MET 49 0.13 HIS 267 -0.33 THR 278

SER 51 0.12 LEU 268 -0.27 THR 278

VAL 53 0.13 ARG 269 -0.28 ILE 282

VAL 53 0.15 GLU 270 -0.35 ILE 282

SER 51 0.20 THR 271 -0.31 ILE 282

VAL 53 0.23 LEU 272 -0.26 ILE 282

VAL 53 0.28 PRO 273 -0.26 SER 276

VAL 53 0.14 LYS 274 -0.33 SER 276

LEU 345 0.11 ILE 275 -0.24 SER 276

LEU 345 0.14 PRO 276 -0.30 TYR 277

ASN 346 0.08 TYR 277 -0.31 GLY 224

ASN 346 0.08 VAL 278 -0.27 ILE 228

GLU 52 0.08 LYS 279 -0.19 LEU 269

VAL 339 0.09 ALA 280 -0.18 THR 275

VAL 339 0.09 ILE 281 -0.20 THR 275

MET 286 0.11 ASP 282 -0.23 LEU 269

VAL 339 0.10 MET 283 -0.21 LEU 269

VAL 339 0.12 TYR 284 -0.20 THR 275

CYS 288 0.11 LEU 285 -0.23 THR 265

ASP 282 0.11 MET 286 -0.23 THR 265

VAL 339 0.11 GLY 287 -0.20 PHE 331

PHE 336 0.12 CYS 288 -0.19 THR 275

SER 322 0.11 PHE 289 -0.23 THR 265

SER 322 0.13 VAL 290 -0.19 THR 265

SER 322 0.15 PHE 291 -0.15 LEU 250

SER 322 0.15 VAL 292 -0.17 THR 261

SER 322 0.16 PHE 293 -0.20 THR 262

SER 322 0.19 MET 294 -0.15 THR 262

SER 322 0.20 ALA 295 -0.13 LEU 250

SER 322 0.21 LEU 296 -0.14 LEU 250

PRO 325 0.23 LEU 297 -0.12 LEU 250

PRO 325 0.25 GLU 298 -0.10 LEU 250

SER 322 0.27 TYR 299 -0.10 LEU 250

PRO 325 0.29 ALA 300 -0.09 LEU 250

PRO 325 0.30 LEU 301 -0.08 LEU 250

PRO 325 0.33 VAL 302 -0.07 PHE 306

PRO 325 0.36 ASN 303 -0.06 PHE 306

PRO 325 0.39 TYR 304 -0.07 LEU 301

PRO 325 0.40 ILE 305 -0.05 VAL 327

PRO 325 0.42 PHE 306 -0.07 VAL 302

PRO 325 0.48 PHE 307 -0.04 ASN 303

PRO 325 0.45 SER 308 -0.04 VAL 327

PRO 325 0.41 GLN 309 -0.03 VAL 327

PRO 325 0.40 PRO 310 -0.10 ALA 313

PRO 325 0.36 ALA 311 -0.06 ALA 313

PRO 325 0.34 ARG 312 -0.04 LEU 250

PRO 325 0.34 ALA 313 -0.10 PRO 310

PRO 325 0.33 ALA 314 -0.04 LEU 250

PRO 325 0.30 ALA 315 -0.05 LEU 250

PRO 325 0.28 ILE 316 -0.07 LEU 250

PRO 325 0.28 ASP 317 -0.07 LEU 250

SER 322 0.27 ARG 318 -0.06 LEU 250

PRO 325 0.25 TRP 319 -0.08 LEU 250

SER 322 0.23 SER 320 -0.09 LEU 250

SER 322 0.24 ARG 321 -0.08 LEU 250

THR 306 0.25 ILE 322 -0.07 LEU 250

SER 322 0.20 PHE 323 -0.10 LEU 250

SER 322 0.19 PHE 324 -0.11 LEU 250

PHE 336 0.22 PRO 325 -0.10 LEU 250

ILE 335 0.23 VAL 326 -0.11 LEU 250

PHE 336 0.19 VAL 327 -0.14 LEU 250

PHE 336 0.20 PHE 328 -0.14 THR 275

PHE 336 0.25 SER 329 -0.12 THR 275

VAL 339 0.22 PHE 330 -0.15 MET 236

VAL 339 0.20 PHE 331 -0.20 GLY 287

VAL 339 0.23 ASN 332 -0.15 GLY 287

VAL 339 0.25 ILE 333 -0.14 GLY 224

VAL 339 0.21 VAL 334 -0.18 ILE 228

VAL 339 0.19 TYR 335 -0.19 ILE 228

VAL 339 0.22 TRP 336 -0.15 GLY 224

VAL 339 0.23 LEU 337 -0.17 LEU 194

VAL 339 0.19 TYR 338 -0.21 GLY 224

VAL 339 0.17 TYR 339 -0.20 GLY 224

THR 343 0.20 VAL 340 -0.19 GLU 183

GLY 22 0.13 ASP 10 -0.07 GLY 25

GLY 25 0.10 ASN 11 -0.08 GLY 25

GLY 22 0.09 THR 12 -0.08 GLY 25

GLY 22 0.12 THR 13 -0.08 GLY 25

GLY 25 0.09 VAL 14 -0.09 GLY 25

GLY 25 0.07 PHE 15 -0.10 GLY 25

GLY 108 0.09 THR 16 -0.10 GLY 25

LYS 93 0.09 ARG 17 -0.11 GLY 25

LYS 93 0.08 ILE 18 -0.12 GLY 25

LYS 93 0.11 LEU 19 -0.12 GLY 25

LYS 93 0.09 ASP 20 -0.13 GLY 25

GLY 108 0.06 ARG 21 -0.16 GLY 25

LYS 93 0.07 LEU 22 -0.17 GLY 25

THR 126 0.07 LEU 23 -0.15 GLY 25

ASN 101 0.07 ASP 24 -0.18 GLY 25

ASN 101 0.06 GLY 25 -0.22 GLY 25

ASN 28 0.06 TYR 26 -0.18 GLY 25

ASP 192 0.06 ASP 27 -0.17 THR 28

TYR 26 0.06 ASN 28 -0.13 ILE 94

GLY 191 0.07 ARG 29 -0.15 LEU 35

ASP 192 0.06 LEU 30 -0.15 LEU 96

ASP 192 0.06 ARG 31 -0.15 LEU 96

ASP 192 0.06 PRO 32 -0.15 ILE 93

ASP 192 0.06 GLY 33 -0.19 ILE 93

ASP 192 0.06 LEU 34 -0.23 ILE 93

GLY 25 0.08 GLY 35 -0.31 ILE 93

ARG 37 0.06 GLU 36 -0.23 ILE 93

GLU 36 0.06 ARG 37 -0.16 ILE 93

ASP 192 0.06 VAL 38 -0.14 ILE 93

ASP 192 0.06 THR 39 -0.14 ILE 93

SER 195 0.05 GLU 40 -0.11 SER 201

SER 195 0.06 VAL 41 -0.12 SER 201

SER 195 0.05 LYS 42 -0.16 SER 201

SER 195 0.05 THR 43 -0.15 SER 201

SER 195 0.04 ASP 44 -0.17 PHE 200

SER 195 0.04 ILE 45 -0.13 LEU 99

ALA 182 0.04 PHE 46 -0.15 LEU 99

SER 201 0.05 VAL 47 -0.14 MET 137

SER 201 0.11 THR 48 -0.21 ASN 100

SER 201 0.08 SER 49 -0.21 CYS 136

ASP 63 0.05 PHE 50 -0.22 MET 137

ALA 109 0.06 GLY 51 -0.21 MET 137

LYS 222 0.07 PRO 52 -0.19 MET 137

ARG 221 0.07 VAL 53 -0.15 MET 137

THR 230 0.08 SER 54 -0.15 LYS 285

PRO 147 0.07 ASP 55 -0.16 ASN 189

THR 230 0.08 HIS 56 -0.15 SER 286

THR 230 0.07 ASP 57 -0.14 GLU 313

ALA 109 0.05 MET 58 -0.14 PHE 339

ALA 109 0.06 GLU 59 -0.13 GLU 313

VAL 135 0.06 TYR 60 -0.15 MET 137

ALA 109 0.07 THR 61 -0.16 MET 137

ALA 109 0.05 ILE 62 -0.15 MET 137

THR 202 0.06 ASP 63 -0.15 ALA 135

GLU 270 0.04 VAL 64 -0.14 LEU 99

THR 202 0.04 PHE 65 -0.14 LEU 99

SER 195 0.05 PHE 66 -0.11 ASP 17

SER 195 0.04 ARG 67 -0.11 ASP 17

SER 195 0.05 GLN 68 -0.11 ASP 17

SER 195 0.05 SER 69 -0.13 SER 201

SER 195 0.05 TRP 70 -0.12 ILE 93

SER 195 0.05 LYS 71 -0.13 ILE 93

SER 195 0.05 ASP 72 -0.14 ILE 93

SER 195 0.04 GLU 73 -0.16 GLY 25

ASP 192 0.05 ARG 74 -0.21 GLY 25

THR 125 0.05 LEU 75 -0.16 GLY 25

THR 125 0.04 LYS 76 -0.15 GLY 25

THR 125 0.04 PHE 77 -0.13 GLY 25

GLY 25 0.04 LYS 78 -0.12 GLY 25

GLY 25 0.05 GLY 79 -0.10 GLY 25

GLY 25 0.05 PRO 80 -0.09 GLY 25

LEU 84 0.06 MET 81 -0.09 GLY 25

THR 271 0.04 THR 82 -0.10 THR 92

THR 271 0.04 VAL 83 -0.10 GLY 25

MET 81 0.06 LEU 84 -0.11 GLY 25

THR 271 0.06 ARG 85 -0.10 GLY 25

THR 271 0.06 LEU 86 -0.10 GLY 25

VAL 108 0.07 ASN 87 -0.11 ASP 17

VAL 108 0.09 ASN 88 -0.12 ASP 17

TRP 123 0.11 LEU 89 -0.13 ASP 17

TRP 123 0.10 MET 90 -0.12 ASP 17

MET 90 0.09 ALA 91 -0.12 ASP 17

LEU 19 0.09 SER 92 -0.14 ASP 17

LEU 19 0.11 LYS 93 -0.14 ASP 17

LEU 19 0.08 ILE 94 -0.13 ASN 28

THR 126 0.07 TRP 95 -0.13 ASN 28

THR 125 0.08 THR 96 -0.12 ASP 17

ASP 192 0.07 PRO 97 -0.12 ASN 99

ASP 192 0.09 ASP 98 -0.16 SER 100

SER 195 0.09 THR 99 -0.13 SER 100

SER 195 0.09 PHE 100 -0.12 ARG 86

SER 195 0.11 PHE 101 -0.11 ARG 86

SER 195 0.14 HIS 102 -0.11 ARG 327

SER 195 0.16 ASN 103 -0.12 ARG 327

SER 195 0.11 GLY 104 -0.12 GLY 108

SER 195 0.10 LYS 105 -0.14 GLY 108

SER 195 0.07 LYS 106 -0.15 GLY 108

ALA 109 0.10 SER 107 -0.14 ARG 86

ALA 109 0.22 VAL 108 -0.15 ARG 86

VAL 108 0.22 ALA 109 -0.17 ARG 86

GLU 270 0.09 HIS 110 -0.15 ASP 89

GLU 270 0.10 ASN 111 -0.14 VAL 106

THR 271 0.10 MET 112 -0.18 VAL 106

THR 271 0.10 THR 113 -0.13 VAL 106

THR 271 0.09 MET 114 -0.12 LYS 21

GLU 270 0.08 PRO 115 -0.14 ASP 17

THR 271 0.08 ASN 116 -0.13 ASP 17

GLU 270 0.07 LYS 117 -0.13 ASP 17

GLU 270 0.06 LEU 118 -0.12 ASP 17

VAL 108 0.06 LEU 119 -0.11 ASP 17

GLU 270 0.05 ARG 120 -0.11 GLY 25

SER 195 0.04 ILE 121 -0.12 GLY 25

THR 271 0.04 THR 122 -0.11 THR 92

THR 271 0.03 GLU 123 -0.11 THR 92

SER 195 0.03 ASP 124 -0.13 THR 92

LEU 127 0.05 GLY 125 -0.13 THR 92

LEU 127 0.09 THR 126 -0.13 ILE 93

THR 126 0.09 LEU 127 -0.12 ILE 93

THR 126 0.04 LEU 128 -0.11 THR 202

SER 195 0.05 TYR 129 -0.12 ASP 17

SER 195 0.05 THR 130 -0.12 ASP 17

LEU 118 0.05 MET 131 -0.12 ASP 17

GLU 270 0.06 ARG 132 -0.12 ASP 17

ALA 109 0.08 LEU 133 -0.14 THR 125

ALA 109 0.07 THR 134 -0.14 ARG 86

ARG 136 0.13 VAL 135 -0.16 ILE 124

VAL 135 0.13 ARG 136 -0.13 MET 137

SER 195 0.08 ALA 137 -0.13 MET 137

SER 195 0.08 GLU 138 -0.12 ASP 75

ALA 248 0.04 CYS 139 -0.12 PHE 339

LEU 357 0.05 PRO 140 -0.16 SER 195

LEU 357 0.05 MET 141 -0.19 SER 195

LEU 357 0.07 HIS 142 -0.22 SER 195

LEU 357 0.05 LEU 143 -0.17 SER 195

LEU 357 0.06 GLU 144 -0.17 PHE 339

ALA 248 0.06 ASP 145 -0.17 PHE 339

ALA 248 0.06 PHE 146 -0.17 PHE 339

ASP 55 0.07 PRO 147 -0.17 TYR 277

ARG 347 0.09 MET 148 -0.16 PHE 339

ASP 55 0.05 ASP 149 -0.15 PHE 339

LYS 220 0.07 ALA 150 -0.14 TYR 338

LEU 357 0.05 HIS 151 -0.14 TYR 338

HIS 218 0.06 ALA 152 -0.18 PRO 154

LEU 357 0.05 CYS 153 -0.18 PRO 154

ARG 194 0.06 PRO 154 -0.18 CYS 153

SER 195 0.08 LEU 155 -0.14 MET 137

SER 195 0.10 LYS 156 -0.12 MET 137

SER 195 0.10 PHE 157 -0.11 MET 137

SER 195 0.09 GLY 158 -0.10 ARG 327

ASP 192 0.09 SER 159 -0.10 ASN 40

ASP 192 0.10 TYR 160 -0.12 ILE 106

GLY 191 0.10 ALA 161 -0.12 ILE 106

ASP 192 0.09 TYR 162 -0.11 LEU 87

ASP 192 0.09 THR 163 -0.11 LEU 140

ASP 192 0.08 ARG 164 -0.10 ASN 346

ASP 192 0.07 ALA 165 -0.11 VAL 95

ASP 192 0.07 GLU 166 -0.15 VAL 95

ASP 192 0.07 VAL 167 -0.12 LEU 96

ASP 192 0.07 VAL 168 -0.11 SER 201

ARG 194 0.06 TYR 169 -0.13 SER 201

ARG 194 0.06 GLU 170 -0.16 SER 201

ARG 194 0.05 TRP 171 -0.19 SER 201

ARG 194 0.05 THR 172 -0.25 SER 201

LEU 357 0.04 ARG 173 -0.28 SER 201

LEU 357 0.05 GLU 174 -0.21 SER 201

LEU 357 0.05 PRO 175 -0.17 SER 201

LEU 357 0.05 ALA 176 -0.16 TYR 338

LEU 357 0.04 ARG 177 -0.21 PHE 200

ARG 194 0.04 SER 178 -0.21 SER 201

ARG 194 0.04 VAL 179 -0.15 PHE 200

LEU 357 0.03 VAL 180 -0.17 VAL 198

ARG 347 0.05 VAL 181 -0.16 ASN 149

SER 201 0.09 ALA 182 -0.20 ASN 149

SER 201 0.09 GLU 183 -0.24 ASN 149

SER 201 0.12 ASP 184 -0.29 ASN 149

SER 201 0.10 GLY 185 -0.26 MET 137

ARG 347 0.07 SER 186 -0.29 MET 137

ASN 346 0.07 ARG 187 -0.28 MET 137

ASN 346 0.07 LEU 188 -0.18 MET 137

ASN 346 0.10 ASN 189 -0.18 LEU 140

LYS 222 0.11 GLN 190 -0.21 TYR 277

ARG 347 0.10 TYR 191 -0.20 TYR 277

ARG 347 0.13 ASP 192 -0.21 ASP 139

ARG 347 0.09 LEU 193 -0.19 ASP 139

ARG 347 0.10 LEU 194 -0.20 TYR 338

ARG 347 0.05 GLY 195 -0.18 TYR 338

LEU 357 0.05 GLN 196 -0.16 TYR 338

LEU 357 0.06 THR 197 -0.15 TYR 338

HIS 216 0.09 VAL 198 -0.14 ASP 199

ARG 194 0.07 ASP 199 -0.14 VAL 198

ARG 194 0.08 SER 200 -0.12 TYR 338

ARG 194 0.08 GLY 201 -0.14 ASN 346

ASP 192 0.09 ILE 202 -0.13 ASN 346

ASP 192 0.13 VAL 203 -0.13 ASN 346

ASP 192 0.13 GLN 204 -0.13 ASN 346

ASP 192 0.15 SER 205 -0.15 ALA 79

GLY 191 0.13 SER 206 -0.17 ALA 79

ASP 192 0.11 THR 207 -0.15 ALA 79

ASP 192 0.11 GLY 208 -0.12 LEU 140

ASP 192 0.11 GLU 209 -0.11 ASN 346

ASP 192 0.11 TYR 210 -0.10 ASN 346

ASP 192 0.09 VAL 211 -0.10 ASN 346

SER 195 0.10 VAL 212 -0.10 ASN 346

SER 195 0.08 MET 213 -0.11 TYR 338

ARG 194 0.08 THR 214 -0.12 TYR 338

ARG 194 0.06 THR 215 -0.13 TYR 338

VAL 198 0.09 HIS 216 -0.22 PHE 217

LEU 194 0.04 PHE 217 -0.22 HIS 216

ALA 152 0.06 HIS 218 -0.16 HIS 216

ARG 347 0.06 LEU 219 -0.16 TYR 338

ARG 347 0.12 LYS 220 -0.17 TYR 338

ARG 347 0.11 ARG 221 -0.20 TYR 277

ARG 347 0.15 LYS 222 -0.26 TYR 277

LEU 345 0.21 ILE 223 -0.23 TYR 277

LEU 345 0.21 GLY 224 -0.31 TYR 277

LEU 345 0.15 TYR 225 -0.27 TYR 277

LEU 345 0.12 PHE 226 -0.24 TYR 277

LEU 345 0.16 VAL 227 -0.21 GLY 224

LEU 345 0.13 ILE 228 -0.27 VAL 278

VAL 53 0.12 GLN 229 -0.23 VAL 278

VAL 53 0.09 THR 230 -0.19 PHE 339

SER 322 0.11 TYR 231 -0.17 TYR 338

LEU 259 0.13 LEU 232 -0.18 TYR 338

LEU 259 0.16 PRO 233 -0.17 PHE 331

LEU 259 0.13 CYS 234 -0.17 PHE 339

SER 322 0.16 ILE 235 -0.17 VAL 334

SER 322 0.17 MET 236 -0.18 PHE 331

SER 322 0.17 THR 237 -0.16 PHE 331

SER 322 0.18 VAL 238 -0.14 PHE 331

PRO 325 0.21 ILE 239 -0.15 PHE 331

SER 322 0.22 LEU 240 -0.14 PHE 331

SER 322 0.23 SER 241 -0.13 LEU 250

PRO 325 0.26 GLN 242 -0.12 PHE 331

PRO 325 0.29 VAL 243 -0.11 PHE 331

PRO 325 0.31 SER 244 -0.10 PHE 331

PRO 325 0.35 PHE 245 -0.08 PHE 331

PRO 325 0.36 TRP 246 -0.07 PRO 340

PRO 325 0.39 LEU 247 -0.06 THR 341

PRO 325 0.46 ASN 248 -0.05 THR 341

PRO 325 0.52 ARG 249 -0.05 ALA 342

SER 322 0.57 GLU 250 -0.05 ALA 342

SER 322 0.49 SER 251 -0.06 ALA 300

SER 322 0.48 VAL 252 -0.06 ALA 342

SER 322 0.39 PRO 253 -0.08 VAL 253

SER 322 0.35 ALA 254 -0.09 ALA 300

SER 322 0.34 ARG 255 -0.09 LEU 250

SER 322 0.30 THR 256 -0.12 VAL 253

ALA 252 0.26 VAL 257 -0.13 LEU 250

SER 322 0.25 PHE 258 -0.15 PHE 293

SER 322 0.23 GLY 259 -0.17 LEU 250

LEU 259 0.18 VAL 260 -0.23 LEU 250

LEU 259 0.21 THR 261 -0.19 PHE 293

SER 322 0.18 THR 262 -0.21 PHE 289

THR 263 0.14 VAL 263 -0.23 LEU 250

THR 263 0.18 LEU 264 -0.25 THR 262

THR 263 0.19 THR 265 -0.28 THR 262

THR 263 0.13 MET 266 -0.19 MET 286

ILE 282 0.15 THR 267 -0.24 ILE 247

HIS 267 0.16 THR 268 -0.33 THR 266

ILE 271 0.13 LEU 269 -0.23 ASP 282

ILE 68 0.11 SER 270 -0.21 PRO 243

LEU 269 0.13 ILE 271 -0.26 PRO 243

ILE 68 0.10 SER 272 -0.25 ARG 269

CYS 234 0.12 ALA 273 -0.22 TYR 277

SER 270 0.09 ARG 274 -0.21 LYS 274

ILE 68 0.08 ASN 275 -0.25 LYS 274

CYS 234 0.08 SER 276 -0.33 LYS 274

CYS 234 0.07 LEU 277 -0.24 LYS 274

ILE 235 0.06 PRO 278 -0.20 LYS 274

ILE 235 0.06 LYS 279 -0.18 PHE 339

LEU 357 0.07 VAL 280 -0.17 PHE 339

LEU 357 0.09 ALA 281 -0.19 PHE 339

LEU 357 0.08 TYR 282 -0.19 PHE 339

LEU 357 0.07 ALA 283 -0.21 PHE 339

LEU 357 0.06 THR 284 -0.19 PHE 339

ALA 248 0.06 ALA 285 -0.19 PHE 339

ILE 235 0.08 MET 286 -0.19 PHE 339

PHE 289 0.11 ASP 287 -0.22 PHE 339

PHE 289 0.11 TRP 288 -0.22 PRO 340

ASP 287 0.11 PHE 289 -0.18 PRO 340

SER 322 0.09 ILE 290 -0.19 PHE 339

LEU 355 0.10 ALA 291 -0.22 PRO 340

ALA 329 0.11 VAL 292 -0.20 PRO 340

SER 322 0.14 CYS 293 -0.17 PRO 340

ALA 329 0.12 TYR 294 -0.20 PHE 339

ALA 329 0.13 ALA 295 -0.22 PRO 340

ALA 329 0.18 PHE 296 -0.17 PRO 340

ALA 329 0.19 VAL 297 -0.15 PHE 339

ALA 329 0.19 PHE 298 -0.16 PHE 339

ALA 329 0.23 SER 299 -0.16 PRO 340

ALA 329 0.26 ALA 300 -0.13 PRO 340

ALA 329 0.27 LEU 301 -0.13 PRO 340

ALA 329 0.29 ILE 302 -0.15 PRO 340

ALA 329 0.33 GLU 303 -0.13 PRO 340

PRO 325 0.36 PHE 304 -0.10 PRO 340

ALA 329 0.40 ALA 305 -0.10 THR 341

ALA 329 0.44 THR 306 -0.17 PHE 310

PRO 325 0.47 VAL 307 -0.10 THR 341

PRO 325 0.51 ASN 308 -0.09 THR 341

ALA 329 0.63 TYR 309 -0.13 THR 306

ALA 329 0.61 PHE 310 -0.17 THR 306

PRO 325 0.66 THR 311 -0.10 THR 341

PRO 325 0.81 LYS 312 -0.10 THR 341

PRO 325 0.79 SER 313 -0.12 THR 341

PRO 325 0.66 GLN 314 -0.12 THR 341

PRO 325 0.62 PRO 315 -0.10 THR 341

PRO 325 0.55 ALA 316 -0.10 THR 341

PRO 325 0.52 ARG 317 -0.12 THR 341

PRO 325 0.53 ALA 318 -0.10 THR 341

PRO 325 0.50 ALA 319 -0.09 THR 341

PRO 325 0.45 LYS 320 -0.10 THR 341

PRO 325 0.43 ILE 321 -0.12 SER 325

PRO 325 0.42 ASP 322 -0.08 THR 341

PRO 325 0.40 ARG 323 -0.08 THR 341

PRO 325 0.37 LEU 324 -0.12 SER 325

PRO 325 0.34 SER 325 -0.12 LEU 324

PRO 325 0.35 ARG 326 -0.09 VAL 334

PRO 325 0.31 ILE 327 -0.09 PRO 340

PRO 325 0.28 ALA 328 -0.11 LEU 324

PRO 325 0.26 PHE 329 -0.12 PRO 340

PRO 325 0.25 PRO 330 -0.11 VAL 334

PRO 325 0.24 LEU 331 -0.11 PRO 340

PRO 325 0.22 LEU 332 -0.13 PRO 340

PRO 325 0.20 PHE 333 -0.13 PRO 340

PRO 325 0.21 GLY 334 -0.11 PRO 340

PRO 325 0.19 ILE 335 -0.14 PRO 340

PRO 325 0.15 PHE 336 -0.17 PRO 340

PRO 325 0.16 ASN 337 -0.14 PRO 340

PRO 325 0.16 LEU 338 -0.14 PRO 340

PRO 325 0.13 VAL 339 -0.17 PRO 340

SER 322 0.11 TYR 340 -0.18 PRO 340

LEU 297 0.13 TRP 341 -0.15 PRO 340

LEU 297 0.13 ALA 342 -0.16 PRO 340

LEU 297 0.11 THR 343 -0.18 PRO 340

ILE 223 0.14 TYR 344 -0.17 PRO 340

ILE 223 0.21 LEU 345 -0.17 ASP 192

GLY 224 0.18 ASN 346 -0.20 ASP 192

ILE 223 0.16 ARG 347 -0.23 ARG 194

GLY 35 0.08 GLY 25 -0.22 GLY 25

GLU 189 0.08 ASP 26 -0.17 GLY 25

ARG 132 0.09 VAL 27 -0.15 ARG 74

GLU 189 0.07 THR 28 -0.17 GLY 25

GLU 189 0.07 VAL 29 -0.18 GLY 25

ILE 133 0.07 ILE 30 -0.12 SER 10

GLU 189 0.07 LEU 31 -0.13 SER 10

SER 187 0.06 ASN 32 -0.15 SER 10

SER 186 0.06 ASN 33 -0.16 SER 10

SER 187 0.05 LEU 34 -0.14 SER 10

ILE 106 0.05 LEU 35 -0.15 ARG 29

LEU 87 0.04 GLU 36 -0.15 SER 10

LEU 87 0.05 GLY 37 -0.20 GLU 14

LEU 87 0.04 TYR 38 -0.18 LYS 13

ARG 86 0.03 ASP 39 -0.18 LYS 13

ASP 10 0.03 ASN 40 -0.23 LYS 105

ASP 10 0.03 LYS 41 -0.16 GLY 104

PRO 44 0.04 LEU 42 -0.14 ARG 327

ASP 84 0.04 ARG 43 -0.14 ARG 327

THR 179 0.04 PRO 44 -0.13 ARG 327

THR 179 0.05 ASP 45 -0.13 ARG 327

THR 179 0.04 ILE 46 -0.13 ARG 327

MET 9 0.08 GLY 47 -0.13 ARG 327

MET 9 0.06 VAL 48 -0.13 ARG 327

LYS 180 0.06 LYS 49 -0.13 ARG 327

LYS 180 0.07 PRO 50 -0.14 ARG 327

LEU 52 0.07 THR 51 -0.14 ARG 327

THR 51 0.07 LEU 52 -0.14 ARG 327

TRP 82 0.07 ILE 53 -0.14 ARG 327

TRP 82 0.09 HIS 54 -0.14 ARG 327

ARG 138 0.08 THR 55 -0.14 ARG 327

LEU 140 0.08 ASP 56 -0.15 ARG 327

LEU 140 0.07 MET 57 -0.15 ARG 327

MET 130 0.07 TYR 58 -0.15 ARG 327

MET 130 0.07 VAL 59 -0.15 ARG 327

TYR 160 0.09 ASN 60 -0.16 ARG 347

LEU 89 0.07 SER 61 -0.15 ARG 327

LEU 89 0.06 ILE 62 -0.17 ARG 327

LEU 89 0.06 GLY 63 -0.16 ARG 327

THR 268 0.05 PRO 64 -0.17 ARG 327

THR 268 0.06 VAL 65 -0.19 ARG 327

THR 268 0.09 ASN 66 -0.18 ARG 327

THR 268 0.10 ALA 67 -0.20 ARG 327

THR 268 0.12 ILE 68 -0.19 ARG 327

THR 268 0.11 ASN 69 -0.19 ARG 327

ASN 69 0.10 MET 70 -0.20 ARG 327

THR 268 0.08 GLU 71 -0.19 ARG 327

THR 268 0.06 TYR 72 -0.18 ARG 327

LEU 89 0.05 THR 73 -0.17 ARG 327

LEU 89 0.06 ILE 74 -0.16 ARG 327

LEU 89 0.06 ASP 75 -0.15 ARG 327

LEU 89 0.06 ILE 76 -0.15 ARG 327

ARG 129 0.09 PHE 77 -0.14 ARG 327

ALA 79 0.07 PHE 78 -0.15 ARG 327

LEU 140 0.08 ALA 79 -0.17 SER 206

LEU 140 0.06 GLN 80 -0.14 THR 207

SER 187 0.07 THR 81 -0.14 THR 207

HIS 54 0.09 TRP 82 -0.13 ARG 327

HIS 54 0.07 TYR 83 -0.12 ARG 327

ASN 208 0.05 ASP 84 -0.12 ARG 327

ASN 208 0.05 ARG 85 -0.12 ARG 327

GLY 37 0.05 ARG 86 -0.12 ARG 327

LYS 88 0.10 LEU 87 -0.13 ARG 132

LEU 87 0.10 LYS 88 -0.11 GLY 35

SER 186 0.07 PHE 89 -0.13 GLY 35

SER 186 0.07 ASN 90 -0.15 GLY 35

SER 186 0.07 SER 91 -0.20 GLY 35

SER 186 0.08 THR 92 -0.25 GLY 35

SER 186 0.08 ILE 93 -0.31 GLY 35

SER 186 0.10 LYS 94 -0.23 GLY 35

SER 186 0.10 VAL 95 -0.20 GLY 35

GLU 189 0.08 LEU 96 -0.18 LEU 34

VAL 27 0.09 ARG 97 -0.15 LEU 96

VAL 27 0.07 LEU 98 -0.11 LEU 87

THR 142 0.08 ASN 99 -0.16 ASP 98

THR 142 0.08 SER 100 -0.16 ASP 98

LEU 23 0.07 ASN 101 -0.14 ASP 98

THR 142 0.06 MET 102 -0.14 ASN 40

TYR 141 0.08 VAL 103 -0.16 ILE 106

ARG 17 0.07 GLY 104 -0.18 ASN 40

ARG 17 0.06 LYS 105 -0.23 ASN 40

ASN 33 0.05 ILE 106 -0.16 VAL 103

ARG 17 0.04 TRP 107 -0.13 ARG 327

ARG 17 0.05 ILE 108 -0.14 ARG 327

ARG 17 0.05 PRO 109 -0.15 ARG 327

ARG 17 0.06 ASP 110 -0.15 ARG 327

ARG 17 0.06 THR 111 -0.16 ARG 327

THR 13 0.06 PHE 112 -0.17 ARG 327

GLN 90 0.07 PHE 113 -0.17 ARG 327

SER 46 0.08 ARG 114 -0.18 ARG 327

GLU 168 0.08 ASN 115 -0.19 ARG 327

ASP 89 0.07 SER 116 -0.18 ARG 327

ASP 89 0.08 LYS 117 -0.18 ARG 327

ASP 89 0.08 LYS 118 -0.17 ARG 327

ASP 89 0.08 ALA 119 -0.16 ARG 327

LEU 89 0.08 ASP 120 -0.19 GLY 108

LEU 89 0.08 ALA 121 -0.14 GLY 108

LEU 89 0.09 HIS 122 -0.13 ARG 327

LEU 89 0.11 TRP 123 -0.14 ARG 86

LEU 89 0.10 ILE 124 -0.16 VAL 135

MET 90 0.09 THR 125 -0.15 ALA 109

MET 90 0.09 THR 126 -0.14 ALA 109

LEU 89 0.08 PRO 127 -0.15 ARG 86

ASN 60 0.08 ASN 128 -0.12 ARG 86

LEU 143 0.09 ARG 129 -0.13 ILE 106

THR 142 0.11 MET 130 -0.13 ILE 106

THR 142 0.10 LEU 131 -0.14 ILE 106

VAL 27 0.09 ARG 132 -0.18 ILE 133

ILE 30 0.07 ILE 133 -0.18 ARG 132

SER 186 0.08 TRP 134 -0.14 GLY 35

SER 186 0.08 ASN 135 -0.16 GLY 35

LYS 184 0.09 ASP 136 -0.13 GLY 35

LYS 184 0.08 GLY 137 -0.11 ARG 327

HIS 54 0.09 ARG 138 -0.11 ARG 327

SER 187 0.08 VAL 139 -0.13 ARG 132

SER 187 0.08 LEU 140 -0.14 THR 207

VAL 103 0.08 TYR 141 -0.13 ARG 327

MET 130 0.11 THR 142 -0.13 ARG 327

ARG 129 0.09 LEU 143 -0.13 ARG 327

LEU 89 0.07 ARG 144 -0.13 ARG 327

LEU 89 0.07 LEU 145 -0.14 ARG 327

LEU 89 0.07 THR 146 -0.15 ARG 327

LEU 89 0.06 ILE 147 -0.16 ARG 327

ASP 89 0.06 ASP 148 -0.17 ARG 327

ASP 89 0.06 ALA 149 -0.18 ARG 327

THR 268 0.07 GLU 150 -0.19 ARG 327

LYS 285 0.09 CYS 151 -0.20 ARG 327

LYS 285 0.09 GLN 152 -0.22 ARG 327

LYS 285 0.10 LEU 153 -0.23 ARG 327

LYS 285 0.08 GLN 154 -0.26 ARG 327

LYS 285 0.09 LEU 155 -0.26 ARG 327

LYS 285 0.06 HIS 156 -0.29 ARG 327

ARG 185 0.06 ASN 157 -0.30 ARG 327

THR 275 0.06 PHE 158 -0.26 ARG 327

LEU 357 0.07 PRO 159 -0.24 ARG 327

LEU 357 0.13 MET 160 -0.27 ARG 327

LYS 285 0.06 ASP 161 -0.26 ARG 327

LEU 357 0.06 GLU 162 -0.24 ARG 327

LYS 285 0.07 HIS 163 -0.23 ARG 327

GLN 154 0.06 SER 164 -0.22 ARG 327

LYS 285 0.07 CYS 165 -0.20 ARG 327

THR 268 0.06 PRO 166 -0.19 ARG 327

THR 268 0.06 LEU 167 -0.18 ARG 327

ASN 115 0.08 GLU 168 -0.18 ARG 327

SER 46 0.06 PHE 169 -0.17 ARG 327

LYS 180 0.06 SER 170 -0.17 ARG 327

LYS 180 0.05 SER 171 -0.16 ARG 327

ARG 114 0.07 TYR 172 -0.16 ARG 327

GLY 127 0.07 GLY 173 -0.16 ARG 327

ARG 173 0.05 TYR 174 -0.15 ARG 327

THR 179 0.07 PRO 175 -0.16 ARG 327

LYS 180 0.07 ARG 176 -0.15 ARG 327

THR 179 0.07 GLU 177 -0.15 ARG 327

THR 179 0.06 GLU 178 -0.15 ARG 327

LYS 180 0.06 ILE 179 -0.15 ARG 327

LYS 180 0.07 VAL 180 -0.15 ARG 327

LYS 180 0.06 TYR 181 -0.15 ARG 327

ARG 138 0.06 GLN 182 -0.15 ARG 327

ASN 208 0.08 TRP 183 -0.15 ARG 327

ARG 138 0.09 LYS 184 -0.14 ARG 327

LEU 357 0.09 ARG 185 -0.14 ARG 327

LYS 94 0.10 SER 186 -0.14 ARG 327

VAL 95 0.09 SER 187 -0.15 ARG 327

VAL 95 0.08 VAL 188 -0.16 ARG 327

VAL 95 0.09 GLU 189 -0.16 ARG 347

SER 206 0.09 VAL 190 -0.17 ARG 347

SER 205 0.13 GLY 191 -0.19 ARG 347

SER 205 0.15 ASP 192 -0.22 ARG 347

SER 205 0.10 THR 193 -0.20 ARG 347

ASN 103 0.11 ARG 194 -0.23 ARG 347

ASN 103 0.16 SER 195 -0.22 HIS 142

ASN 103 0.07 TRP 196 -0.16 ARG 347

LEU 89 0.05 ARG 197 -0.16 ARG 327

LEU 357 0.06 LEU 198 -0.17 ARG 327

LEU 357 0.06 TYR 199 -0.17 ARG 327

LEU 357 0.06 GLN 200 -0.19 ARG 327

LEU 357 0.08 PHE 201 -0.20 ARG 327

LEU 357 0.12 SER 202 -0.20 ARG 327

LEU 357 0.11 PHE 203 -0.19 ARG 327

LEU 357 0.14 VAL 204 -0.20 ARG 327

LEU 357 0.12 GLY 205 -0.19 ARG 327

LYS 94 0.08 LEU 206 -0.19 ARG 327

ARG 185 0.08 ARG 207 -0.19 ARG 327

TRP 183 0.08 ASN 208 -0.18 ARG 327

ARG 138 0.07 THR 209 -0.18 ARG 327

LYS 180 0.07 THR 210 -0.17 ARG 327

LYS 180 0.09 GLU 211 -0.17 ARG 327

LYS 180 0.11 VAL 212 -0.17 ARG 327

LYS 180 0.14 VAL 213 -0.17 ARG 327

THR 179 0.11 LYS 214 -0.18 ARG 327

THR 176 0.12 THR 215 -0.18 ARG 327

ALA 174 0.11 THR 216 -0.18 ARG 327

ASN 41 0.08 SER 217 -0.17 ARG 327

THR 176 0.08 GLY 218 -0.17 ARG 327

THR 179 0.08 ASP 219 -0.17 ARG 327

LYS 180 0.08 TYR 220 -0.17 ARG 327

LYS 180 0.09 VAL 221 -0.16 ARG 327

LYS 180 0.10 VAL 222 -0.17 ARG 327

LYS 180 0.07 MET 223 -0.17 ARG 327

ARG 138 0.06 SER 224 -0.18 ARG 327

ARG 138 0.06 VAL 225 -0.18 ARG 327

LYS 94 0.06 TYR 226 -0.19 ARG 327

LYS 94 0.06 PHE 227 -0.19 ARG 327

LEU 357 0.07 ASP 228 -0.21 ARG 327

LEU 357 0.08 LEU 229 -0.21 ARG 327

LEU 357 0.13 SER 230 -0.22 ARG 327

LEU 357 0.10 ARG 231 -0.22 ARG 327

LEU 357 0.16 ARG 232 -0.20 ARG 327

LEU 357 0.16 MET 233 -0.22 ASN 347

LEU 357 0.14 GLY 234 -0.20 PHE 339

LEU 357 0.10 TYR 235 -0.18 PHE 339

LEU 357 0.09 PHE 236 -0.20 PHE 339

LEU 355 0.15 THR 237 -0.23 PHE 339

LEU 355 0.12 ILE 238 -0.21 PHE 339

THR 267 0.09 GLN 239 -0.21 GLU 270

LEU 355 0.10 THR 240 -0.22 GLU 313

LEU 355 0.15 TYR 241 -0.22 PHE 339

LEU 355 0.15 ILE 242 -0.22 PHE 339

LEU 355 0.11 PRO 243 -0.26 ILE 271

LEU 355 0.10 CYS 244 -0.23 THR 266

TRP 351 0.13 THR 245 -0.29 PHE 339

LEU 355 0.11 LEU 246 -0.22 PHE 339

LEU 250 0.14 ILE 247 -0.25 THR 266

TRP 351 0.10 VAL 248 -0.27 GLU 313

TRP 351 0.10 VAL 249 -0.25 PHE 339

ALA 329 0.15 LEU 250 -0.23 VAL 263

ALA 329 0.12 SER 251 -0.22 GLU 313

ALA 329 0.15 TRP 252 -0.18 THR 266

ALA 329 0.24 VAL 253 -0.15 THR 266

ALA 329 0.25 SER 254 -0.14 THR 266

ALA 329 0.30 PHE 255 -0.13 THR 266

ALA 329 0.44 TRP 256 -0.12 ALA 342

ALA 329 0.45 ILE 257 -0.09 ALA 342

ALA 329 0.59 ASN 258 -0.09 ALA 342

ASN 258 0.46 LYS 259 -0.12 ALA 342

SER 322 0.60 ASP 260 -0.10 ALA 342

VAL 252 0.47 ALA 261 -0.08 ALA 342

SER 322 0.40 VAL 262 -0.07 ALA 342

ALA 249 0.32 PRO 263 -0.07 GLU 313

SER 322 0.29 ALA 264 -0.10 GLU 313

SER 322 0.24 ARG 265 -0.14 GLU 313

SER 239 0.19 THR 266 -0.14 THR 256

LEU 253 0.26 SER 267 -0.18 THR 256

SER 322 0.19 LEU 268 -0.20 LEU 259

LEU 235 0.11 GLY 269 -0.26 GLU 313

SER 267 0.21 ILE 270 -0.23 GLU 313

SER 267 0.18 THR 271 -0.26 THR 263

PRO 228 0.10 THR 272 -0.25 THR 263

PRO 228 0.14 VAL 273 -0.27 GLU 313

PRO 228 0.18 LEU 274 -0.31 THR 263

THR 277 0.15 THR 275 -0.33 THR 263

GLN 224 0.12 MET 276 -0.30 THR 266

THR 275 0.15 THR 277 -0.27 HIS 267

LEU 264 0.18 THR 278 -0.33 HIS 267

THR 275 0.15 LEU 279 -0.30 GLU 270

THR 275 0.12 SER 280 -0.27 GLU 270

LEU 264 0.12 THR 281 -0.29 GLU 270

THR 267 0.15 ILE 282 -0.35 GLU 270

LEU 264 0.10 ALA 283 -0.30 GLU 270

LYS 289 0.10 ARG 284 -0.26 GLU 270

PRO 288 0.13 LYS 285 -0.28 GLU 270

THR 267 0.12 SER 286 -0.20 PRO 273

LYS 285 0.12 LEU 287 -0.21 ARG 327

LYS 285 0.13 PRO 288 -0.21 ARG 327

LYS 285 0.12 LYS 289 -0.22 ARG 327

LYS 285 0.09 VAL 290 -0.25 ARG 327

THR 275 0.08 SER 291 -0.28 ARG 327

THR 275 0.07 TYR 292 -0.31 ARG 327

THR 275 0.07 VAL 293 -0.33 ARG 327

THR 275 0.06 THR 294 -0.31 ARG 327

LEU 250 0.06 ALA 295 -0.29 ARG 327

THR 275 0.08 MET 296 -0.25 ARG 327

MET 276 0.07 ASP 297 -0.28 ARG 327

LEU 250 0.05 LEU 298 -0.33 ARG 327

LEU 250 0.08 PHE 299 -0.29 ARG 327

LEU 250 0.09 VAL 300 -0.25 ARG 327

LEU 250 0.05 SER 301 -0.32 ARG 327

LEU 250 0.04 VAL 302 -0.38 ILE 305

LEU 250 0.06 CYS 303 -0.27 GLU 313

SER 251 0.09 PHE 304 -0.25 THR 266

PRO 340 0.08 ILE 305 -0.38 VAL 302

PRO 340 0.11 PHE 306 -0.29 GLU 313

SER 251 0.10 VAL 307 -0.31 GLU 313

PRO 340 0.08 PHE 308 -0.36 GLU 313

PRO 340 0.10 SER 309 -0.52 GLU 313

PRO 340 0.11 ALA 310 -0.53 GLU 313

LYS 312 0.09 LEU 311 -0.40 GLU 313

LYS 312 0.08 VAL 312 -0.55 THR 316

LYS 312 0.11 GLU 313 -0.53 ALA 310

LYS 312 0.12 TYR 314 -0.15 THR 266

TRP 241 0.20 GLY 315 -0.39 VAL 312

LYS 312 0.24 THR 316 -0.55 VAL 312

LYS 312 0.31 LEU 317 -0.30 VAL 312

LYS 312 0.35 HIS 318 -0.21 VAL 312

LYS 312 0.36 TYR 319 -0.30 VAL 238

LYS 312 0.43 PHE 320 -0.32 ILE 322

LYS 312 0.57 VAL 321 -0.27 ILE 322

LYS 312 0.65 SER 322 -0.39 ILE 322

LYS 312 0.58 SER 323 -0.58 ILE 322

LYS 312 0.66 GLN 324 -0.49 ILE 322

LYS 312 0.81 PRO 325 -0.36 ILE 322

SER 313 0.76 ALA 326 -0.36 ILE 322

SER 313 0.54 ARG 327 -0.39 VAL 349

SER 313 0.50 ALA 328 -0.26 VAL 349

SER 313 0.67 ALA 329 -0.20 ILE 322

SER 313 0.43 LYS 330 -0.32 MET 331

SER 313 0.18 MET 331 -0.32 LYS 330

ALA 329 0.18 ASP 332 -0.20 ALA 342

LYS 330 0.20 SER 333 -0.21 ALA 342

LYS 312 0.11 TYR 334 -0.31 ALA 342

LYS 312 0.09 ALA 335 -0.31 ALA 342

ALA 329 0.12 ARG 336 -0.20 ALA 342

LYS 312 0.08 ILE 337 -0.28 ALA 342

LYS 312 0.08 PHE 338 -0.59 ALA 342

ALA 310 0.08 PHE 339 -0.31 PHE 343

ALA 310 0.11 PRO 340 -0.22 ALA 291

PHE 306 0.06 THR 341 -0.32 PHE 338

PHE 304 0.05 ALA 342 -0.59 PHE 338

LYS 312 0.04 PHE 343 -0.32 PHE 338

LYS 312 0.05 CYS 344 -0.23 PHE 338

LYS 312 0.04 LEU 345 -0.31 ARG 327

LEU 250 0.04 PHE 346 -0.34 ARG 327

VAL 249 0.08 ASN 347 -0.25 ARG 327

VAL 349 0.18 LEU 348 -0.25 ARG 327

LEU 348 0.18 VAL 349 -0.39 ARG 327

LEU 250 0.05 TYR 350 -0.35 ARG 327

THR 245 0.13 TRP 351 -0.28 ARG 327

ILE 242 0.10 VAL 352 -0.31 ARG 327

ILE 242 0.07 SER 353 -0.37 ARG 327

TYR 241 0.11 TYR 354 -0.32 ARG 327

ILE 242 0.15 LEU 355 -0.27 ARG 327

ILE 242 0.12 TYR 356 -0.31 ARG 327

MET 233 0.16 LEU 357 -0.33 ARG 327

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: April 25th, 2023.

Should you encounter any unexpected behaviour, please let us know.

*** 6x3x ***

CA distance fluctuations for 2403121503062936047

--- normal mode 27 ---

Should you encounter any unexpected behaviour,
please let us know.

* 6x3x *