Should you encounter any unexpected behaviour,
please let us know.

* r191c *

CA distance fluctuations for 240323151426237850

--- normal mode 14 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
SER 519 0.25 MET 1 -0.30 PHE 607

SER 519 0.28 ALA 2 -0.30 PHE 607

SER 519 0.29 ALA 3 -0.28 TRP 606

SER 519 0.24 ALA 4 -0.22 PHE 388

ASN 513 0.26 LYS 5 -0.26 PHE 388

ASN 513 0.25 VAL 6 -0.24 THR 410

ASN 513 0.24 ALA 7 -0.30 THR 410

ASN 513 0.22 LEU 8 -0.31 PHE 414

GLY 516 0.20 THR 9 -0.38 PHE 414

SER 510 0.21 LYS 10 -0.42 PHE 414

SER 510 0.21 ARG 11 -0.41 PHE 414

SER 510 0.23 ALA 12 -0.46 LYS 418

SER 510 0.23 ASP 13 -0.45 PHE 414

SER 510 0.21 PRO 14 -0.41 LYS 418

SER 510 0.23 ALA 15 -0.44 LYS 418

SER 510 0.25 GLU 16 -0.53 LYS 418

GLU 514 0.23 LEU 17 -0.49 LYS 418

SER 510 0.22 ARG 18 -0.46 LYS 418

SER 510 0.24 THR 19 -0.52 LYS 418

GLU 514 0.25 ILE 20 -0.55 LYS 418

GLU 514 0.23 PHE 21 -0.48 LYS 418

GLU 514 0.22 LEU 22 -0.48 LYS 418

GLU 514 0.24 LYS 23 -0.53 LYS 418

GLU 514 0.24 TYR 24 -0.52 LYS 422

GLU 514 0.21 ALA 25 -0.45 LYS 418

GLU 514 0.20 SER 26 -0.43 LYS 418

GLU 514 0.18 ILE 27 -0.39 LYS 418

GLU 514 0.18 GLU 28 -0.37 LYS 418

GLU 514 0.16 LYS 29 -0.34 LYS 418

GLU 514 0.15 ASN 30 -0.31 LYS 418

GLU 514 0.16 GLY 31 -0.33 LYS 418

GLU 514 0.17 GLU 32 -0.35 LYS 418

GLU 514 0.18 PHE 33 -0.39 LYS 418

GLU 514 0.19 PHE 34 -0.39 LYS 418

GLU 514 0.20 MET 35 -0.42 LYS 418

GLU 514 0.19 SER 36 -0.43 LYS 422

GLU 514 0.19 PRO 37 -0.45 LYS 422

GLU 514 0.21 ASN 38 -0.51 LYS 422

GLU 514 0.22 ASP 39 -0.53 LYS 422

GLU 514 0.23 PHE 40 -0.52 LYS 422

GLU 514 0.23 VAL 41 -0.55 LYS 422

GLU 514 0.24 THR 42 -0.62 LYS 422

GLU 514 0.26 ARG 43 -0.66 LYS 422

GLU 514 0.27 TYR 44 -0.65 LYS 422

GLU 514 0.28 LEU 45 -0.66 LYS 422

GLU 514 0.29 ASN 46 -0.72 LYS 422

GLU 514 0.27 ILE 47 -0.67 LYS 422

GLU 514 0.25 PHE 48 -0.66 LYS 422

GLU 514 0.29 GLY 49 -0.75 LYS 422

GLU 514 0.27 GLU 50 -0.71 LYS 422

GLU 514 0.23 SER 51 -0.64 LYS 422

GLU 514 0.20 GLN 52 -0.58 LYS 422

GLU 514 0.20 PRO 53 -0.55 LYS 422

GLU 514 0.16 ASN 54 -0.49 LYS 422

GLU 514 0.16 PRO 55 -0.46 LYS 422

GLU 514 0.15 LYS 56 -0.42 LYS 422

GLU 514 0.16 THR 57 -0.45 LYS 422

GLU 514 0.18 VAL 58 -0.47 LYS 422

GLU 514 0.16 GLU 59 -0.41 LYS 422

GLU 514 0.15 LEU 60 -0.39 LYS 422

GLU 514 0.18 LEU 61 -0.43 LYS 422

GLU 514 0.18 SER 62 -0.41 LYS 422

GLU 514 0.16 GLY 63 -0.35 LYS 422

GLU 514 0.16 VAL 64 -0.35 LYS 418

GLU 514 0.18 VAL 65 -0.36 LYS 418

GLU 514 0.16 ASP 66 -0.34 LYS 418

GLU 514 0.15 GLN 67 -0.31 LYS 418

GLU 514 0.14 THR 68 -0.30 LYS 418

GLU 514 0.14 LYS 69 -0.31 LYS 418

GLU 514 0.14 ASP 70 -0.31 LYS 418

GLU 514 0.16 GLY 71 -0.34 LYS 418

GLU 514 0.17 LEU 72 -0.36 LYS 418

GLU 514 0.18 ILE 73 -0.38 LYS 418

GLU 514 0.18 SER 74 -0.36 LYS 418

GLU 514 0.19 PHE 75 -0.38 LYS 418

GLU 514 0.17 GLN 76 -0.34 LYS 418

GLU 514 0.17 GLU 77 -0.35 LYS 418

GLU 514 0.20 PHE 78 -0.40 LYS 418

GLU 514 0.19 VAL 79 -0.38 LYS 418

GLU 514 0.17 ALA 80 -0.34 LYS 418

GLU 514 0.18 PHE 81 -0.37 LYS 418

GLU 514 0.20 GLU 82 -0.40 LYS 418

ASN 513 0.17 SER 83 -0.34 PHE 414

ASN 513 0.17 VAL 84 -0.33 LYS 418

GLU 514 0.19 LEU 85 -0.37 LYS 418

GLY 516 0.18 CYS 86 -0.36 PHE 414

ASN 513 0.19 ALA 87 -0.30 PHE 414

ASN 513 0.19 PRO 88 -0.28 PHE 414

ASN 513 0.17 ASP 89 -0.26 PHE 414

ASN 513 0.16 ALA 90 -0.31 LYS 418

ASN 513 0.14 LEU 91 -0.31 LYS 418

ASN 513 0.14 PHE 92 -0.28 LYS 418

ASN 513 0.15 MET 93 -0.29 LYS 418

GLU 514 0.15 VAL 94 -0.32 LYS 418

GLU 514 0.12 ALA 95 -0.31 LYS 422

ASP 423 0.13 PHE 96 -0.28 LYS 418

GLU 514 0.13 GLN 97 -0.30 LYS 418

GLU 514 0.13 LEU 98 -0.32 LYS 422

ASP 423 0.12 PHE 99 -0.28 LYS 422

ASP 423 0.13 ASP 100 -0.27 LYS 418

ASP 423 0.12 LYS 101 -0.28 LYS 418

ASP 423 0.13 ALA 102 -0.26 LYS 418

ASP 423 0.13 GLY 103 -0.27 LYS 418

ASP 423 0.15 LYS 104 -0.24 PHE 387

ASP 423 0.16 GLY 105 -0.25 PHE 387

ASP 423 0.16 GLU 106 -0.24 PHE 387

ASP 423 0.15 VAL 107 -0.24 LYS 418

ASP 423 0.15 THR 108 -0.23 LYS 418

ASP 423 0.15 PHE 109 -0.23 LYS 422

ASP 423 0.14 GLU 110 -0.25 LYS 422

ASP 423 0.13 ASP 111 -0.26 LYS 422

ASP 423 0.13 VAL 112 -0.27 LYS 422

PHE 375 0.13 LYS 113 -0.28 LYS 422

PHE 375 0.13 GLN 114 -0.31 LYS 422

PHE 375 0.13 VAL 115 -0.33 LYS 422

PHE 375 0.14 PHE 116 -0.32 LYS 422

PHE 375 0.15 GLY 117 -0.33 LYS 422

PHE 375 0.15 GLN 118 -0.37 LYS 422

PHE 375 0.16 THR 119 -0.38 LYS 422

PHE 375 0.18 THR 120 -0.40 LYS 422

LYS 379 0.18 ILE 121 -0.37 LYS 422

LYS 379 0.17 HIS 122 -0.34 LYS 422

LYS 379 0.18 GLN 123 -0.36 LYS 422

LYS 379 0.20 HIS 124 -0.36 LYS 422

LYS 379 0.19 ILE 125 -0.33 LYS 422

LYS 379 0.18 PRO 126 -0.31 LYS 422

LYS 379 0.16 PHE 127 -0.29 LYS 422

LYS 379 0.15 ASN 128 -0.26 LYS 422

LYS 422 0.14 TRP 129 -0.25 LYS 422

LYS 422 0.16 ASP 130 -0.23 LYS 422

LYS 422 0.16 SER 131 -0.22 LYS 422

LYS 422 0.19 GLU 132 -0.19 LYS 422

LYS 422 0.18 PHE 133 -0.20 LYS 422

LYS 422 0.17 VAL 134 -0.21 LYS 422

LYS 422 0.19 GLN 135 -0.19 LYS 422

LYS 422 0.20 LEU 136 -0.19 ARG 383

LYS 422 0.19 HIS 137 -0.20 ARG 383

LYS 422 0.18 PHE 138 -0.20 ARG 383

LYS 422 0.20 GLY 139 -0.21 ARG 383

LYS 422 0.19 LYS 140 -0.20 ARG 383

LYS 422 0.18 GLU 141 -0.20 ARG 383

LYS 422 0.17 ARG 142 -0.20 ARG 383

ASP 423 0.18 LYS 143 -0.22 ARG 383

ASP 423 0.19 ARG 144 -0.22 ARG 383

ASP 423 0.18 HIS 145 -0.23 PHE 387

ASP 423 0.18 LEU 146 -0.23 PHE 387

ASP 423 0.18 THR 147 -0.25 PHE 387

ASP 423 0.17 TYR 148 -0.24 PHE 387

ASP 423 0.18 ALA 149 -0.24 PHE 387

ASP 423 0.19 GLU 150 -0.23 PHE 387

ASP 423 0.16 PHE 151 -0.22 LYS 418

ASP 423 0.15 THR 152 -0.22 LYS 418

ASP 423 0.17 GLN 153 -0.20 LYS 418

ASP 423 0.16 PHE 154 -0.21 LYS 418

ASP 423 0.13 LEU 155 -0.25 LYS 422

LYS 422 0.13 LEU 156 -0.24 LYS 422

LYS 422 0.15 GLU 157 -0.22 LYS 422

LYS 422 0.14 ILE 158 -0.25 LYS 422

LYS 379 0.15 GLN 159 -0.28 LYS 422

LYS 379 0.16 LEU 160 -0.25 LYS 422

LYS 379 0.15 GLU 161 -0.24 LYS 422

LYS 379 0.17 HIS 162 -0.28 LYS 422

LYS 379 0.18 ALA 163 -0.28 LYS 422

ARG 383 0.18 LYS 164 -0.25 LYS 422

LYS 379 0.18 GLN 165 -0.26 LYS 422

LYS 379 0.19 ALA 166 -0.29 LYS 422

ARG 383 0.20 PHE 167 -0.27 LYS 422

ARG 383 0.19 VAL 168 -0.25 LYS 422

ARG 383 0.20 GLN 169 -0.27 LYS 422

ARG 383 0.22 ARG 170 -0.28 LYS 422

ARG 383 0.22 ASP 171 -0.26 LYS 422

ARG 383 0.22 ASN 172 -0.26 LYS 422

ARG 383 0.22 ALA 173 -0.24 LYS 422

ARG 383 0.21 ARG 174 -0.23 LYS 422

ARG 383 0.22 THR 175 -0.22 LYS 422

ARG 383 0.22 GLY 176 -0.22 LYS 422

ARG 383 0.24 ARG 177 -0.24 ASP 423

ARG 383 0.24 VAL 178 -0.27 ASP 423

ARG 383 0.26 THR 179 -0.29 ASP 423

ARG 383 0.27 ALA 180 -0.30 ASP 423

ARG 383 0.27 ILE 181 -0.33 ASP 423

ARG 383 0.25 ASP 182 -0.32 ASP 423

ARG 383 0.24 PHE 183 -0.31 ASP 423

ARG 383 0.25 ARG 184 -0.34 ASP 423

LYS 379 0.24 ASP 185 -0.35 ASP 423

LYS 379 0.22 ILE 186 -0.33 LYS 422

LYS 379 0.22 MET 187 -0.34 ASP 423

LYS 379 0.23 VAL 188 -0.38 ASP 423

LYS 379 0.21 THR 189 -0.37 LYS 422

LYS 379 0.20 ILE 190 -0.34 LYS 422

LYS 379 0.20 CYS 191 -0.34 LYS 422

LYS 379 0.21 PRO 192 -0.39 LYS 422

LYS 379 0.19 HIS 193 -0.39 LYS 422

LYS 379 0.20 VAL 194 -0.34 LYS 422

LYS 379 0.23 LEU 195 -0.38 ASP 423

LEU 602 0.25 THR 196 -0.41 ASP 423

LYS 379 0.28 PRO 197 -0.45 ASP 423

PHE 387 0.30 PHE 198 -0.41 ASP 423

PHE 387 0.28 VAL 199 -0.37 ASP 423

LYS 379 0.27 GLU 200 -0.39 ASP 423

LYS 379 0.30 GLU 201 -0.40 ASP 423

PHE 387 0.31 CYS 202 -0.35 ASP 423

PHE 387 0.28 LEU 203 -0.34 ASP 423

ARG 383 0.30 VAL 204 -0.33 ASP 423

PHE 387 0.32 ALA 205 -0.32 ASP 423

PHE 387 0.31 ALA 206 -0.30 ASP 423

PHE 387 0.29 ALA 207 -0.29 ASP 423

ARG 383 0.31 GLY 208 -0.29 ASP 423

PHE 387 0.33 GLY 209 -0.27 ASP 423

PHE 387 0.31 THR 210 -0.25 ASP 423

ARG 383 0.32 THR 211 -0.25 ASP 423

ARG 383 0.30 SER 212 -0.25 ASP 423

ARG 383 0.30 HIS 213 -0.28 ASP 423

ARG 383 0.27 GLN 214 -0.26 ASP 423

ARG 383 0.25 VAL 215 -0.26 ASP 423

ARG 383 0.24 SER 216 -0.24 ASP 423

ARG 383 0.21 PHE 217 -0.23 LYS 422

PHE 387 0.21 SER 218 -0.21 ASP 423

PHE 387 0.23 TYR 219 -0.23 ASP 423

PHE 387 0.22 PHE 220 -0.25 ASP 423

PHE 387 0.20 ASN 221 -0.23 LYS 422

PHE 387 0.21 GLY 222 -0.22 ASP 423

PHE 387 0.23 PHE 223 -0.26 ASP 423

PHE 387 0.20 ASN 224 -0.26 LYS 422

PHE 387 0.19 SER 225 -0.22 LYS 422

PHE 387 0.21 LEU 226 -0.23 ASP 423

PHE 387 0.20 LEU 227 -0.27 ASP 423

PHE 387 0.17 ASN 228 -0.25 LYS 422

PHE 387 0.17 ASN 229 -0.21 LYS 422

LEU 602 0.20 MET 230 -0.23 LYS 422

LEU 602 0.18 GLU 231 -0.19 LYS 422

TRP 606 0.16 LEU 232 -0.16 GLY 424

TRP 606 0.20 ILE 233 -0.18 GLY 424

TRP 606 0.23 ARG 234 -0.19 ASN 513

TRP 606 0.19 LYS 235 -0.17 ASN 513

TRP 606 0.19 ILE 236 -0.19 ASN 513

TRP 606 0.26 TYR 237 -0.24 ASN 513

TRP 606 0.27 SER 238 -0.23 ASN 513

TRP 606 0.18 THR 239 -0.21 ASN 513

TRP 606 0.23 LEU 240 -0.24 ASN 513

TRP 606 0.32 ALA 241 -0.27 ASN 513

TRP 606 0.28 GLY 242 -0.23 SER 519

TRP 606 0.41 THR 243 -0.27 SER 519

TRP 606 0.55 ARG 244 -0.34 SER 519

TRP 606 0.52 LYS 245 -0.39 SER 519

TRP 606 0.48 ASP 246 -0.40 ASN 513

TRP 606 0.43 VAL 247 -0.34 ASN 513

PHE 387 0.36 GLU 248 -0.34 ASN 513

PHE 387 0.32 VAL 249 -0.29 ASN 513

PHE 387 0.33 THR 250 -0.27 ASN 513

PHE 387 0.30 LYS 251 -0.24 ASN 513

PHE 387 0.28 GLU 252 -0.22 ASN 513

PHE 387 0.27 GLU 253 -0.23 ASN 513

PHE 387 0.25 PHE 254 -0.22 ASN 513

PHE 387 0.23 VAL 255 -0.19 ASN 513

PHE 414 0.23 LEU 256 -0.19 ASN 513

PHE 387 0.20 ALA 257 -0.19 ASN 513

PHE 414 0.19 ALA 258 -0.17 ASN 513

PHE 414 0.24 GLN 259 -0.15 ASN 513

ASP 417 0.23 LYS 260 -0.14 ASN 513

ASP 417 0.20 PHE 261 -0.13 LEU 602

ASP 417 0.23 GLY 262 -0.14 LEU 602

ASP 417 0.19 GLN 263 -0.13 LYS 422

PHE 387 0.18 VAL 264 -0.15 ASP 423

PHE 387 0.20 THR 265 -0.16 ASP 423

PHE 387 0.23 PRO 266 -0.17 ASP 423

PHE 387 0.24 MET 267 -0.20 ASP 423

PHE 387 0.23 GLU 268 -0.21 ASP 423

PHE 387 0.25 VAL 269 -0.20 ASP 423

PHE 387 0.28 ASP 270 -0.22 ASP 423

PHE 387 0.27 ILE 271 -0.25 ASP 423

PHE 387 0.28 LEU 272 -0.25 ASP 423

PHE 387 0.31 PHE 273 -0.24 ASP 423

PHE 387 0.32 GLN 274 -0.26 ASP 423

PHE 387 0.31 LEU 275 -0.29 ASP 423

PHE 387 0.34 ALA 276 -0.29 ASP 423

PHE 387 0.37 ASP 277 -0.28 ASP 423

PHE 387 0.36 LEU 278 -0.31 ASP 423

PHE 387 0.38 TYR 279 -0.34 ASP 423

PHE 387 0.41 GLU 280 -0.34 GLU 514

PHE 387 0.41 PRO 281 -0.31 GLU 514

PHE 387 0.42 ARG 282 -0.32 GLU 514

PHE 387 0.38 GLY 283 -0.28 GLU 514

PHE 387 0.37 ARG 284 -0.30 ASN 513

PHE 387 0.34 MET 285 -0.31 ASN 513

TRP 606 0.37 THR 286 -0.36 ASN 513

TRP 606 0.37 LEU 287 -0.35 ASN 513

LEU 602 0.41 ALA 288 -0.41 GLU 514

LEU 602 0.34 ASP 289 -0.34 GLU 514

LEU 602 0.30 ILE 290 -0.27 ASP 423

LEU 602 0.33 GLU 291 -0.32 GLY 424

LEU 602 0.32 ARG 292 -0.36 ASP 423

LEU 602 0.28 ILE 293 -0.33 ASP 423

LEU 602 0.26 ALA 294 -0.31 ASP 423

LEU 602 0.24 PRO 295 -0.34 ASP 423

LEU 602 0.24 LEU 296 -0.38 ASP 423

LEU 602 0.21 GLU 297 -0.35 LYS 422

LEU 602 0.19 GLU 298 -0.43 LYS 422

LEU 602 0.16 GLY 299 -0.37 LYS 422

LEU 602 0.15 THR 300 -0.34 LYS 422

SER 519 0.20 LEU 301 -0.43 LYS 422

ASP 515 0.20 PRO 302 -0.39 LYS 422

GLY 516 0.16 PHE 303 -0.35 ASP 417

GLY 516 0.19 ASN 304 -0.39 ASP 417

GLY 516 0.27 LEU 305 -0.47 ASP 417

GLY 516 0.23 ALA 306 -0.42 ASP 417

GLY 516 0.20 GLU 307 -0.38 PHE 414

GLY 516 0.29 ALA 308 -0.48 ASP 417

GLY 516 0.29 GLN 309 -0.49 ASP 417

GLY 516 0.22 ARG 310 -0.42 PHE 414

GLY 516 0.22 GLN 311 -0.44 PHE 414

ALA 509 0.28 LYS 312 -0.57 PHE 414

ASP 423 0.32 ALA 313 -0.52 PHE 414

ASP 423 0.37 SER 314 -0.44 THR 410

ASP 423 0.44 GLY 315 -0.55 THR 410

GLY 424 0.67 ASP 316 -0.49 THR 410

ASP 423 0.59 SER 317 -0.34 LYS 10

GLY 424 0.56 ALA 318 -0.32 LYS 10

GLY 424 0.49 ARG 319 -0.28 ALA 7

GLY 424 0.50 PRO 320 -0.26 LEU 471

GLY 424 0.60 VAL 321 -0.30 LEU 399

GLY 424 0.50 LEU 322 -0.30 LEU 471

GLY 424 0.40 LEU 323 -0.25 LYS 5

GLY 424 0.45 GLN 324 -0.24 LEU 471

GLY 424 0.45 VAL 325 -0.29 LEU 399

TRP 606 0.43 ALA 326 -0.25 LEU 471

TRP 606 0.38 GLU 327 -0.21 LEU 471

TRP 606 0.34 SER 328 -0.26 ALA 402

TRP 606 0.43 ALA 329 -0.32 GLY 333

TRP 606 0.51 TYR 330 -0.23 ALA 329

TRP 606 0.35 ARG 331 -0.18 GLY 315

TRP 606 0.39 PHE 332 -0.25 GLY 315

TRP 606 0.44 GLY 333 -0.32 ALA 329

TRP 606 0.34 LEU 334 -0.23 PRO 403

TRP 606 0.29 GLY 335 -0.21 PHE 479

TRP 606 0.33 SER 336 -0.22 PHE 479

ASP 246 0.26 VAL 337 -0.28 PRO 403

ASP 246 0.26 ALA 338 -0.30 PRO 403

ASP 246 0.20 GLY 339 -0.27 PHE 479

ASP 246 0.25 ALA 340 -0.30 PHE 479

ASP 246 0.32 VAL 341 -0.35 PRO 403

GLU 280 0.27 GLY 342 -0.33 PHE 414

GLU 280 0.24 ALA 343 -0.33 PHE 479

ARG 282 0.31 THR 344 -0.39 PHE 479

GLU 280 0.35 ALA 345 -0.40 PHE 479

GLU 280 0.30 VAL 346 -0.38 PHE 479

GLU 280 0.28 TYR 347 -0.39 PHE 479

GLU 280 0.32 PRO 348 -0.44 PHE 479

GLU 280 0.28 ILE 349 -0.39 PHE 479

GLU 280 0.24 ASP 350 -0.36 PHE 479

GLU 280 0.26 LEU 351 -0.40 PHE 479

GLU 280 0.27 VAL 352 -0.40 PHE 479

GLU 280 0.21 LYS 353 -0.35 PHE 479

PHE 387 0.24 THR 354 -0.33 PHE 479

GLU 280 0.22 ARG 355 -0.36 PHE 479

GLU 280 0.21 MET 356 -0.35 PHE 479

PHE 387 0.25 GLN 357 -0.31 PHE 479

PHE 387 0.26 ASN 358 -0.31 PHE 479

GLY 386 0.23 GLN 359 -0.33 PHE 479

GLY 386 0.25 ARG 360 -0.29 PHE 479

GLY 386 0.23 SER 361 -0.30 PHE 479

GLY 386 0.24 THR 362 -0.27 PHE 479

GLY 386 0.23 GLY 363 -0.27 PHE 479

GLY 386 0.22 SER 364 -0.27 PHE 479

GLY 386 0.20 PHE 365 -0.29 PHE 479

GLU 280 0.20 VAL 366 -0.32 PHE 479

GLU 280 0.21 GLY 367 -0.33 PHE 479

GLU 280 0.24 GLU 368 -0.37 PHE 479

GLU 280 0.23 LEU 369 -0.37 PHE 479

GLU 280 0.26 MET 370 -0.40 PHE 479

GLU 280 0.26 TYR 371 -0.41 PHE 479

GLU 280 0.26 LYS 372 -0.39 PHE 479

GLU 280 0.27 ASN 373 -0.39 PHE 479

GLU 280 0.28 SER 374 -0.40 PHE 479

GLU 280 0.33 PHE 375 -0.44 PHE 479

GLU 280 0.32 ASP 376 -0.45 PHE 479

GLU 280 0.31 CYS 377 -0.45 PHE 479

GLU 280 0.35 PHE 378 -0.48 PHE 479

GLU 280 0.38 LYS 379 -0.52 PHE 479

GLU 280 0.35 LYS 380 -0.52 PHE 479

GLU 280 0.34 VAL 381 -0.53 PHE 479

GLU 280 0.39 LEU 382 -0.59 PHE 479

GLU 280 0.39 ARG 383 -0.60 PHE 479

ARG 282 0.36 TYR 384 -0.59 PHE 479

ARG 282 0.36 GLU 385 -0.61 PHE 479

ARG 282 0.40 GLY 386 -0.67 PHE 479

ARG 282 0.42 PHE 387 -0.66 PHE 479

ARG 282 0.39 PHE 388 -0.65 PHE 479

ARG 282 0.35 GLY 389 -0.58 PHE 479

ARG 282 0.35 LEU 390 -0.52 PHE 479

ARG 282 0.34 TYR 391 -0.49 PHE 479

ARG 282 0.31 ARG 392 -0.46 PHE 479

ARG 282 0.26 GLY 393 -0.37 PHE 479

ARG 282 0.28 LEU 394 -0.37 PHE 479

ARG 282 0.27 LEU 395 -0.32 PHE 479

PHE 387 0.32 PRO 396 -0.25 PHE 479

PHE 387 0.29 GLN 397 -0.27 PHE 479

PHE 387 0.24 LEU 398 -0.27 PHE 479

PHE 387 0.33 LEU 399 -0.30 VAL 321

PHE 387 0.39 GLY 400 -0.28 GLY 315

PHE 387 0.31 VAL 401 -0.25 GLY 315

LEU 602 0.32 ALA 402 -0.31 GLY 315

PHE 387 0.41 PRO 403 -0.38 GLY 315

PHE 387 0.39 GLU 404 -0.33 GLY 315

PHE 387 0.33 LYS 405 -0.31 GLY 315

LEU 602 0.36 ALA 406 -0.43 GLY 315

PHE 387 0.43 ILE 407 -0.45 GLY 315

PHE 387 0.37 LYS 408 -0.35 GLY 315

LEU 602 0.34 LEU 409 -0.44 MET 617

LEU 602 0.39 THR 410 -0.55 GLY 315

PHE 387 0.41 VAL 411 -0.45 GLY 315

PHE 387 0.35 ASN 412 -0.42 MET 617

VAL 325 0.40 ASP 413 -0.51 MET 617

LYS 379 0.39 PHE 414 -0.59 PRO 634

LYS 379 0.38 VAL 415 -0.56 PRO 634

VAL 321 0.41 ARG 416 -0.53 PRO 632

VAL 321 0.52 ASP 417 -0.70 PRO 634

VAL 321 0.42 LYS 418 -0.77 PRO 634

VAL 321 0.41 PHE 419 -0.68 PRO 634

VAL 321 0.50 MET 420 -0.74 ALA 631

VAL 321 0.50 HIS 421 -0.83 ALA 631

VAL 321 0.56 LYS 422 -1.05 ALA 631

ASP 316 0.66 ASP 423 -1.03 ALA 631

ASP 316 0.67 GLY 424 -0.87 ALA 631

ASP 316 0.51 SER 425 -0.65 ALA 631

VAL 321 0.44 VAL 426 -0.55 ALA 631

VAL 321 0.37 PRO 427 -0.46 ALA 631

VAL 321 0.31 LEU 428 -0.32 ALA 631

LYS 379 0.31 ALA 429 -0.36 ALA 631

LYS 379 0.33 ALA 430 -0.45 ALA 631

PHE 387 0.31 GLU 431 -0.36 ALA 631

PHE 387 0.32 ILE 432 -0.29 ALA 631

PHE 387 0.35 LEU 433 -0.36 ALA 631

PHE 387 0.36 ALA 434 -0.39 PRO 634

PHE 387 0.34 GLY 435 -0.29 PRO 634

PHE 387 0.37 GLY 436 -0.31 PRO 634

PHE 387 0.42 CYS 437 -0.39 PRO 634

PHE 387 0.40 ALA 438 -0.35 PRO 634

PHE 387 0.40 GLY 439 -0.28 PRO 634

PHE 387 0.45 GLY 440 -0.33 PRO 634

PHE 387 0.49 SER 441 -0.37 GLU 16

PHE 387 0.46 GLN 442 -0.33 GLY 315

PHE 387 0.48 VAL 443 -0.31 GLU 16

PHE 387 0.56 ILE 444 -0.37 GLU 16

PHE 387 0.55 PHE 445 -0.36 ASP 316

PHE 387 0.46 THR 446 -0.29 GLY 315

PHE 387 0.48 ASN 447 -0.29 ALA 15

PHE 387 0.52 PRO 448 -0.31 ALA 15

PHE 387 0.44 LEU 449 -0.27 ALA 15

PHE 387 0.39 GLU 450 -0.24 ALA 15

PHE 387 0.41 ILE 451 -0.25 ALA 15

PHE 387 0.39 VAL 452 -0.25 ALA 15

PHE 387 0.32 LYS 453 -0.28 PHE 479

PHE 387 0.31 ILE 454 -0.29 PHE 479

PHE 387 0.32 ARG 455 -0.28 PHE 479

PHE 387 0.26 LEU 456 -0.34 PHE 479

ARG 282 0.25 GLN 457 -0.38 PHE 479

ARG 282 0.24 VAL 458 -0.36 PHE 479

ARG 282 0.25 ALA 459 -0.37 PHE 479

ARG 282 0.29 GLY 460 -0.46 PHE 479

ARG 282 0.28 GLU 461 -0.44 PHE 479

ARG 282 0.27 ILE 462 -0.41 PHE 479

ARG 282 0.30 THR 463 -0.48 PHE 479

ARG 282 0.28 THR 464 -0.42 PHE 479

ARG 282 0.26 GLY 465 -0.36 PHE 479

ARG 282 0.27 PRO 466 -0.34 GLY 478

ARG 282 0.28 ARG 467 -0.39 GLY 478

ARG 282 0.25 VAL 468 -0.31 PHE 479

VAL 321 0.28 SER 469 -0.28 GLY 478

PHE 388 0.34 ALA 470 -0.26 VAL 321

PHE 388 0.42 LEU 471 -0.29 ALA 15

PHE 388 0.39 SER 472 -0.28 ALA 15

PHE 388 0.41 VAL 473 -0.27 ALA 15

PHE 388 0.52 VAL 474 -0.31 ALA 15

PHE 388 0.54 ARG 475 -0.32 ALA 15

GLY 386 0.49 ASP 476 -0.30 ALA 15

GLY 386 0.53 LEU 477 -0.31 ALA 15

GLY 386 0.64 GLY 478 -0.35 ALA 15

GLY 386 0.71 PHE 479 -0.38 ALA 15

GLY 386 0.66 PHE 480 -0.37 ALA 15

GLY 386 0.57 GLY 481 -0.33 ALA 15

PHE 387 0.56 ILE 482 -0.32 ALA 15

PHE 387 0.56 TYR 483 -0.33 ALA 15

GLY 386 0.51 LYS 484 -0.29 ALA 15

PHE 387 0.46 GLY 485 -0.26 ALA 15

PHE 387 0.49 ALA 486 -0.29 GLU 16

PHE 387 0.47 LYS 487 -0.29 GLU 16

PHE 387 0.41 ALA 488 -0.23 GLU 16

PHE 387 0.42 CYS 489 -0.24 GLU 16

PHE 387 0.43 PHE 490 -0.27 GLU 16

PHE 387 0.39 LEU 491 -0.22 PRO 634

PHE 387 0.36 ARG 492 -0.18 PHE 479

PHE 387 0.37 ASP 493 -0.20 PRO 634

PHE 387 0.38 ILE 494 -0.25 PRO 634

PHE 387 0.34 PRO 495 -0.18 PRO 634

PHE 387 0.31 PHE 496 -0.18 PHE 479

PHE 387 0.32 SER 497 -0.22 MET 617

PHE 387 0.32 ALA 498 -0.20 PRO 675

PHE 387 0.28 ILE 499 -0.18 PRO 675

PHE 387 0.26 TYR 500 -0.19 LYS 418

PHE 387 0.27 PHE 501 -0.21 MET 617

PHE 387 0.26 PRO 502 -0.23 GLY 516

PHE 387 0.23 CYS 503 -0.21 LYS 422

PHE 387 0.21 TYR 504 -0.21 LYS 422

VAL 321 0.28 ALA 505 -0.22 GLY 516

ASP 316 0.26 HIS 506 -0.20 GLU 280

ASP 316 0.22 VAL 507 -0.25 LYS 422

ASP 316 0.23 LYS 508 -0.23 LYS 422

ASP 316 0.31 ALA 509 -0.27 ALA 512

PRO 634 0.32 SER 510 -0.30 ASP 246

ALA 631 0.32 PHE 511 -0.34 ASP 246

PRO 632 0.32 ALA 512 -0.34 ASP 246

ALA 631 0.37 ASN 513 -0.40 ASP 246

ALA 631 0.48 GLU 514 -0.41 ALA 288

ALA 631 0.38 ASP 515 -0.41 GLY 424

PRO 632 0.33 GLY 516 -0.37 GLY 424

SER 519 0.28 GLN 517 -0.33 ASP 246

ALA 631 0.23 VAL 518 -0.36 LYS 245

LYS 624 0.36 SER 519 -0.39 LYS 245

LYS 624 0.29 PRO 520 -0.33 PRO 320

LYS 624 0.30 GLY 521 -0.38 PRO 320

LYS 624 0.25 SER 522 -0.33 PRO 320

LYS 624 0.17 LEU 523 -0.28 LYS 422

GLY 594 0.20 LEU 524 -0.32 LYS 418

SER 590 0.22 LEU 525 -0.34 LYS 418

ALA 631 0.17 ALA 526 -0.28 LYS 418

PHE 387 0.17 GLY 527 -0.27 LYS 418

PHE 387 0.16 ALA 528 -0.31 LYS 418

PHE 387 0.17 ILE 529 -0.30 LYS 418

PHE 387 0.20 ALA 530 -0.26 LYS 418

PHE 387 0.22 GLY 531 -0.26 LYS 418

PHE 387 0.20 MET 532 -0.29 LYS 418

PHE 387 0.22 PRO 533 -0.27 LYS 418

PHE 387 0.25 ALA 534 -0.23 LYS 418

PHE 387 0.25 ALA 535 -0.25 LYS 418

PHE 387 0.24 SER 536 -0.26 LYS 418

PHE 387 0.27 LEU 537 -0.23 LYS 418

PHE 387 0.30 VAL 538 -0.21 PHE 479

PHE 387 0.28 THR 539 -0.24 PHE 479

PHE 387 0.30 PRO 540 -0.23 PHE 479

PHE 387 0.34 ALA 541 -0.21 PHE 479

PHE 387 0.32 ASP 542 -0.23 PHE 479

PHE 387 0.30 VAL 543 -0.25 PHE 479

PHE 387 0.35 ILE 544 -0.21 PHE 479

PHE 387 0.37 LYS 545 -0.21 PHE 479

PHE 387 0.33 THR 546 -0.25 PHE 479

GLY 386 0.34 ARG 547 -0.24 PHE 479

GLY 386 0.39 LEU 548 -0.22 ALA 15

PHE 387 0.39 GLN 549 -0.23 ALA 15

GLY 386 0.35 VAL 550 -0.24 PHE 479

GLY 386 0.36 ALA 551 -0.23 PHE 479

GLY 386 0.35 ALA 552 -0.22 PHE 479

GLY 386 0.30 ARG 553 -0.25 PHE 479

GLY 386 0.30 ALA 554 -0.23 PHE 479

GLY 386 0.29 GLY 555 -0.23 PHE 479

GLY 386 0.31 GLN 556 -0.24 PHE 479

GLY 386 0.33 THR 557 -0.21 PHE 479

GLY 386 0.38 THR 558 -0.21 ALA 15

GLY 386 0.40 TYR 559 -0.22 ALA 15

GLY 386 0.45 SER 560 -0.26 ALA 15

GLY 386 0.45 GLY 561 -0.25 ALA 15

GLY 386 0.41 VAL 562 -0.23 GLU 16

ARG 383 0.40 ILE 563 -0.22 THR 19

GLY 386 0.40 ASP 564 -0.21 ALA 15

GLY 386 0.37 CYS 565 -0.19 ALA 15

GLY 386 0.35 PHE 566 -0.19 PHE 479

ARG 383 0.35 ARG 567 -0.18 PHE 479

GLY 386 0.33 LYS 568 -0.19 PHE 479

GLY 386 0.31 ILE 569 -0.22 PHE 479

GLY 386 0.30 LEU 570 -0.21 PHE 479

GLY 386 0.30 ARG 571 -0.21 PHE 479

GLY 386 0.28 GLU 572 -0.23 PHE 479

GLY 386 0.26 GLU 573 -0.25 PHE 479

GLY 386 0.26 GLY 574 -0.24 PHE 479

GLY 386 0.26 PRO 575 -0.24 PHE 479

GLY 386 0.24 LYS 576 -0.26 PHE 479

GLY 386 0.25 ALA 577 -0.27 PHE 479

PHE 387 0.27 LEU 578 -0.25 PHE 479

PHE 387 0.24 TRP 579 -0.27 PHE 479

PHE 387 0.23 LYS 580 -0.30 PHE 479

PHE 387 0.21 GLY 581 -0.32 PHE 479

PHE 387 0.22 ALA 582 -0.29 PHE 479

PHE 387 0.18 GLY 583 -0.33 LYS 418

GLU 280 0.20 ALA 584 -0.34 PHE 479

PHE 387 0.21 ARG 585 -0.30 PHE 479

PHE 387 0.19 VAL 586 -0.31 LYS 418

TYR 279 0.21 PHE 587 -0.35 LYS 418

GLU 280 0.21 ARG 588 -0.33 PHE 414

PHE 387 0.19 SER 589 -0.30 PHE 414

LEU 525 0.22 SER 590 -0.34 PHE 414

GLU 280 0.24 PRO 591 -0.38 PHE 414

GLU 280 0.21 GLN 592 -0.34 PHE 414

LYS 624 0.16 PHE 593 -0.32 PHE 414

LYS 624 0.25 GLY 594 -0.37 PHE 414

ALA 288 0.29 VAL 595 -0.40 PHE 414

ALA 288 0.22 THR 596 -0.33 PHE 414

ALA 288 0.22 LEU 597 -0.32 PHE 414

ALA 288 0.32 LEU 598 -0.39 PHE 414

ASP 246 0.33 THR 599 -0.38 THR 410

ALA 288 0.25 TYR 600 -0.31 THR 410

ALA 288 0.31 GLU 601 -0.33 ALA 326

ASP 246 0.45 LEU 602 -0.43 ALA 326

ASP 246 0.35 LEU 603 -0.33 THR 410

ASP 246 0.28 GLN 604 -0.30 TYR 330

LYS 245 0.43 ARG 605 -0.41 ALA 326

ARG 244 0.55 TRP 606 -0.49 TYR 330

ARG 244 0.42 PHE 607 -0.38 GLY 333

THR 243 0.29 TYR 608 -0.30 TYR 330

THR 243 0.27 ILE 609 -0.23 GLY 333

SER 519 0.19 ASP 610 -0.19 GLY 333

ARG 605 0.28 PHE 611 -0.20 ALA 4

SER 519 0.26 GLY 612 -0.18 ALA 4

GLY 521 0.27 GLY 613 -0.24 ALA 406

GLY 521 0.23 VAL 614 -0.35 THR 410

GLY 521 0.19 LYS 615 -0.30 THR 410

ALA 509 0.22 PRO 616 -0.38 THR 410

LYS 312 0.28 MET 617 -0.51 ASP 413

LYS 312 0.20 GLY 618 -0.36 ASP 413

GLY 594 0.17 SER 619 -0.24 ASP 413

SER 519 0.21 GLU 620 -0.28 ASP 413

SER 519 0.31 PRO 621 -0.32 GLY 424

SER 519 0.25 VAL 622 -0.45 GLY 424

SER 519 0.23 PRO 623 -0.43 GLY 424

SER 519 0.36 LYS 624 -0.56 GLY 424

SER 519 0.28 SER 625 -0.55 GLY 424

SER 519 0.27 ARG 626 -0.58 ASP 423

SER 519 0.25 ILE 627 -0.61 ASP 423

GLU 514 0.32 ASN 628 -0.74 ASP 423

GLU 514 0.35 LEU 629 -0.76 LYS 422

GLU 514 0.37 PRO 630 -0.88 LYS 422

GLU 514 0.48 ALA 631 -1.05 LYS 422

GLU 514 0.44 PRO 632 -1.02 LYS 422

GLU 514 0.38 ASN 633 -0.97 LYS 422

GLU 514 0.37 PRO 634 -0.96 LYS 422

GLU 514 0.31 ASP 635 -0.73 LYS 422

GLU 514 0.31 HIS 636 -0.66 LYS 422

GLU 514 0.28 VAL 637 -0.60 LYS 418

GLU 514 0.25 GLY 638 -0.51 LYS 418

GLU 514 0.23 GLY 639 -0.45 LYS 418

GLU 514 0.26 TYR 640 -0.50 LYS 418

GLU 514 0.30 LYS 641 -0.57 LYS 422

GLU 514 0.26 LEU 642 -0.49 LYS 422

GLU 514 0.25 ALA 643 -0.50 LYS 422

GLU 514 0.27 VAL 644 -0.59 LYS 422

GLU 514 0.25 ALA 645 -0.54 LYS 422

GLU 514 0.20 THR 646 -0.44 LYS 422

GLU 514 0.19 PHE 647 -0.47 LYS 422

GLU 514 0.19 ALA 648 -0.50 LYS 422

SER 519 0.17 GLY 649 -0.43 LYS 422

SER 519 0.15 ILE 650 -0.39 LYS 422

PHE 375 0.16 GLU 651 -0.42 LYS 422

PHE 375 0.17 ASN 652 -0.41 LYS 422

LEU 602 0.15 LYS 653 -0.35 LYS 422

PHE 375 0.14 PHE 654 -0.33 LYS 422

LYS 379 0.16 GLY 655 -0.37 LYS 422

PHE 375 0.15 LEU 656 -0.38 LYS 422

PHE 375 0.17 TYR 657 -0.43 LYS 422

PHE 375 0.16 LEU 658 -0.44 LYS 422

PHE 375 0.18 PRO 659 -0.46 LYS 422

PHE 375 0.18 LEU 660 -0.52 LYS 422

PHE 375 0.19 PHE 661 -0.52 LYS 422

PHE 375 0.18 LYS 662 -0.48 LYS 422

PHE 375 0.20 PRO 663 -0.45 LYS 422

PHE 375 0.20 SER 664 -0.46 LYS 422

PHE 375 0.20 VAL 665 -0.42 LYS 422

PHE 375 0.21 SER 666 -0.41 LYS 422

PHE 375 0.20 THR 667 -0.40 LYS 422

LYS 379 0.18 SER 668 -0.39 LYS 422

LYS 379 0.18 LYS 669 -0.41 LYS 422

LYS 379 0.16 ALA 670 -0.39 LYS 422

LYS 379 0.16 ILE 671 -0.42 LYS 422

LYS 379 0.15 GLY 672 -0.39 LYS 422

LYS 379 0.14 GLY 673 -0.42 LYS 422

ARG 383 0.11 GLY 674 -0.42 ASP 423

ARG 383 0.10 PRO 675 -0.40 ASP 423

PHE 607 0.28 MET 1 -0.26 GLY 612

PHE 607 0.28 ALA 2 -0.28 GLY 424

TRP 606 0.26 ALA 3 -0.26 SER 519

PHE 388 0.22 ALA 4 -0.23 ASP 423

PHE 388 0.26 LYS 5 -0.28 ASP 423

THR 410 0.24 VAL 6 -0.23 ASN 513

THR 410 0.29 ALA 7 -0.23 ASP 423

THR 410 0.30 LEU 8 -0.20 ASN 513

PHE 414 0.37 THR 9 -0.22 GLY 516

PHE 414 0.41 LYS 10 -0.23 SER 510

PHE 414 0.40 ARG 11 -0.22 SER 510

PHE 414 0.45 ALA 12 -0.25 SER 510

PHE 414 0.44 ASP 13 -0.25 SER 510

PHE 414 0.40 PRO 14 -0.23 SER 510

LYS 418 0.42 ALA 15 -0.25 SER 510

LYS 418 0.51 GLU 16 -0.27 SER 510

LYS 418 0.48 LEU 17 -0.25 GLU 514

LYS 418 0.44 ARG 18 -0.24 SER 510

LYS 418 0.50 THR 19 -0.26 SER 510

LYS 418 0.54 ILE 20 -0.27 GLU 514

LYS 418 0.47 PHE 21 -0.25 GLU 514

LYS 418 0.47 LEU 22 -0.24 GLU 514

LYS 418 0.52 LYS 23 -0.26 GLU 514

LYS 422 0.50 TYR 24 -0.26 GLU 514

LYS 418 0.44 ALA 25 -0.23 GLU 514

LYS 418 0.43 SER 26 -0.22 GLU 514

LYS 418 0.39 ILE 27 -0.20 GLU 514

LYS 418 0.36 GLU 28 -0.19 GLU 514

LYS 418 0.33 LYS 29 -0.18 GLU 514

LYS 418 0.31 ASN 30 -0.17 GLU 514

LYS 418 0.32 GLY 31 -0.18 GLU 514

LYS 418 0.34 GLU 32 -0.19 GLU 514

LYS 418 0.38 PHE 33 -0.20 GLU 514

LYS 418 0.38 PHE 34 -0.20 GLU 514

LYS 418 0.41 MET 35 -0.22 GLU 514

LYS 422 0.41 SER 36 -0.21 GLU 514

LYS 422 0.43 PRO 37 -0.21 GLU 514

LYS 422 0.49 ASN 38 -0.23 GLU 514

LYS 422 0.50 ASP 39 -0.24 GLU 514

LYS 422 0.49 PHE 40 -0.25 GLU 514

LYS 422 0.53 VAL 41 -0.25 GLU 514

LYS 422 0.60 THR 42 -0.27 GLU 514

LYS 422 0.63 ARG 43 -0.29 GLU 514

LYS 422 0.62 TYR 44 -0.30 GLU 514

LYS 422 0.63 LEU 45 -0.30 GLU 514

LYS 422 0.70 ASN 46 -0.32 GLU 514

LYS 422 0.65 ILE 47 -0.29 GLU 514

LYS 422 0.65 PHE 48 -0.27 GLU 514

LYS 422 0.74 GLY 49 -0.32 GLU 514

LYS 422 0.71 GLU 50 -0.29 GLU 514

LYS 422 0.63 SER 51 -0.25 GLU 514

LYS 422 0.57 GLN 52 -0.22 GLU 514

LYS 422 0.54 PRO 53 -0.21 GLU 514

LYS 422 0.48 ASN 54 -0.18 GLU 514

LYS 422 0.45 PRO 55 -0.18 GLU 514

LYS 422 0.41 LYS 56 -0.16 GLU 514

LYS 422 0.44 THR 57 -0.17 GLU 514

LYS 422 0.46 VAL 58 -0.20 GLU 514

LYS 422 0.40 GLU 59 -0.18 GLU 514

LYS 422 0.37 LEU 60 -0.17 GLU 514

LYS 422 0.41 LEU 61 -0.19 GLU 514

LYS 422 0.39 SER 62 -0.20 GLU 514

LYS 418 0.34 GLY 63 -0.17 GLU 514

LYS 418 0.34 VAL 64 -0.18 GLU 514

LYS 418 0.35 VAL 65 -0.19 GLU 514

LYS 418 0.33 ASP 66 -0.18 GLU 514

LYS 418 0.30 GLN 67 -0.16 GLU 514

LYS 418 0.28 THR 68 -0.15 GLU 514

LYS 418 0.30 LYS 69 -0.15 GLU 514

LYS 418 0.30 ASP 70 -0.16 GLU 514

LYS 418 0.33 GLY 71 -0.17 GLU 514

LYS 418 0.35 LEU 72 -0.19 GLU 514

LYS 418 0.36 ILE 73 -0.20 GLU 514

LYS 418 0.35 SER 74 -0.19 GLU 514

LYS 418 0.37 PHE 75 -0.21 GLU 514

LYS 418 0.33 GLN 76 -0.19 GLU 514

LYS 418 0.34 GLU 77 -0.19 GLU 514

LYS 418 0.39 PHE 78 -0.21 GLU 514

LYS 418 0.37 VAL 79 -0.21 GLU 514

LYS 418 0.32 ALA 80 -0.19 GLU 514

LYS 418 0.35 PHE 81 -0.20 GLU 514

LYS 418 0.39 GLU 82 -0.22 GLU 514

PHE 414 0.34 SER 83 -0.19 GLU 514

PHE 414 0.31 VAL 84 -0.18 GLU 514

LYS 418 0.36 LEU 85 -0.21 GLU 514

PHE 414 0.35 CYS 86 -0.20 GLY 516

PHE 414 0.29 ALA 87 -0.17 ASN 513

PHE 414 0.27 PRO 88 -0.18 ASN 513

PHE 414 0.26 ASP 89 -0.16 ASN 513

LYS 418 0.30 ALA 90 -0.15 GLU 514

LYS 418 0.30 LEU 91 -0.14 GLU 514

LYS 418 0.26 PHE 92 -0.13 ASN 513

LYS 418 0.27 MET 93 -0.13 ASN 513

LYS 418 0.31 VAL 94 -0.16 GLU 514

LYS 418 0.29 ALA 95 -0.13 GLU 514

LYS 418 0.26 PHE 96 -0.13 ASP 423

LYS 418 0.29 GLN 97 -0.14 GLU 514

LYS 418 0.30 LEU 98 -0.14 GLU 514

LYS 418 0.27 PHE 99 -0.13 ASP 423

LYS 418 0.26 ASP 100 -0.13 ASP 423

LYS 418 0.27 LYS 101 -0.13 GLU 514

LYS 418 0.25 ALA 102 -0.13 ASP 423

LYS 418 0.26 GLY 103 -0.13 ASP 423

PHE 387 0.25 LYS 104 -0.15 ASP 423

PHE 387 0.25 GLY 105 -0.16 ASP 423

PHE 387 0.24 GLU 106 -0.16 ASP 423

LYS 418 0.22 VAL 107 -0.16 ASP 423

LYS 418 0.22 THR 108 -0.16 ASP 423

LYS 418 0.22 PHE 109 -0.16 ASP 423

LYS 418 0.23 GLU 110 -0.14 ASP 423

LYS 418 0.25 ASP 111 -0.13 ASP 423

LYS 422 0.26 VAL 112 -0.13 ASP 423

LYS 422 0.27 LYS 113 -0.13 PHE 375

LYS 422 0.29 GLN 114 -0.13 PHE 375

LYS 422 0.31 VAL 115 -0.14 PHE 375

LYS 422 0.31 PHE 116 -0.15 PHE 375

LYS 422 0.32 GLY 117 -0.15 PHE 375

LYS 422 0.36 GLN 118 -0.16 PHE 375

LYS 422 0.37 THR 119 -0.17 PHE 375

LYS 422 0.40 THR 120 -0.19 PHE 375

LYS 422 0.36 ILE 121 -0.19 LYS 379

LYS 422 0.33 HIS 122 -0.18 LYS 379

LYS 422 0.36 GLN 123 -0.19 LYS 379

LYS 422 0.36 HIS 124 -0.20 LYS 379

LYS 422 0.32 ILE 125 -0.20 LYS 379

LYS 422 0.30 PRO 126 -0.18 LYS 379

LYS 422 0.28 PHE 127 -0.16 LYS 379

LYS 422 0.25 ASN 128 -0.16 LYS 379

LYS 422 0.24 TRP 129 -0.15 LYS 422

LYS 422 0.21 ASP 130 -0.16 LYS 422

LYS 422 0.21 SER 131 -0.17 LYS 422

LYS 422 0.18 GLU 132 -0.19 LYS 422

LYS 422 0.19 PHE 133 -0.19 LYS 422

LYS 422 0.20 VAL 134 -0.18 LYS 422

ARG 383 0.18 GLN 135 -0.20 LYS 422

ARG 383 0.19 LEU 136 -0.21 LYS 422

ARG 383 0.20 HIS 137 -0.20 LYS 422

ARG 383 0.20 PHE 138 -0.19 LYS 422

ARG 383 0.21 GLY 139 -0.20 LYS 422

ARG 383 0.20 LYS 140 -0.20 LYS 422

ARG 383 0.20 GLU 141 -0.19 LYS 422

ARG 383 0.20 ARG 142 -0.18 LYS 422

ARG 383 0.22 LYS 143 -0.18 ASP 423

ARG 383 0.22 ARG 144 -0.19 ASP 423

PHE 387 0.23 HIS 145 -0.18 ASP 423

PHE 387 0.23 LEU 146 -0.18 ASP 423

PHE 387 0.25 THR 147 -0.18 ASP 423

PHE 387 0.24 TYR 148 -0.17 ASP 423

PHE 387 0.24 ALA 149 -0.19 ASP 423

PHE 387 0.23 GLU 150 -0.19 ASP 423

PHE 387 0.21 PHE 151 -0.17 ASP 423

LYS 418 0.21 THR 152 -0.16 ASP 423

PHE 387 0.20 GLN 153 -0.18 ASP 423

LYS 418 0.20 PHE 154 -0.17 LYS 422

LYS 422 0.23 LEU 155 -0.14 LYS 422

LYS 422 0.22 LEU 156 -0.14 LYS 422

LYS 422 0.21 GLU 157 -0.16 LYS 422

LYS 422 0.24 ILE 158 -0.15 LYS 422

LYS 422 0.27 GLN 159 -0.16 LYS 379

LYS 422 0.24 LEU 160 -0.16 LYS 379

LYS 422 0.23 GLU 161 -0.15 LYS 379

LYS 422 0.27 HIS 162 -0.17 LYS 379

LYS 422 0.27 ALA 163 -0.18 LYS 379

LYS 422 0.24 LYS 164 -0.18 LYS 379

LYS 422 0.25 GLN 165 -0.18 LYS 379

LYS 422 0.28 ALA 166 -0.20 LYS 379

LYS 422 0.27 PHE 167 -0.20 ARG 383

LYS 422 0.25 VAL 168 -0.19 ARG 383

LYS 422 0.27 GLN 169 -0.20 ARG 383

LYS 422 0.28 ARG 170 -0.22 ARG 383

LYS 422 0.25 ASP 171 -0.22 ARG 383

LYS 422 0.25 ASN 172 -0.22 ARG 383

LYS 422 0.24 ALA 173 -0.22 ARG 383

LYS 422 0.22 ARG 174 -0.21 ARG 383

LYS 422 0.22 THR 175 -0.22 ARG 383

LYS 422 0.22 GLY 176 -0.22 ARG 383

ASP 423 0.24 ARG 177 -0.24 ARG 383

ASP 423 0.27 VAL 178 -0.24 ARG 383

ASP 423 0.29 THR 179 -0.27 ARG 383

ASP 423 0.31 ALA 180 -0.28 ARG 383

ASP 423 0.33 ILE 181 -0.27 ARG 383

ASP 423 0.32 ASP 182 -0.25 ARG 383

ASP 423 0.31 PHE 183 -0.25 ARG 383

ASP 423 0.34 ARG 184 -0.26 LYS 379

ASP 423 0.35 ASP 185 -0.25 LYS 379

LYS 422 0.32 ILE 186 -0.22 LYS 379

ASP 423 0.33 MET 187 -0.23 LYS 379

ASP 423 0.38 VAL 188 -0.24 LYS 379

LYS 422 0.37 THR 189 -0.22 LYS 379

LYS 422 0.34 ILE 190 -0.20 LYS 379

LYS 422 0.34 CYS 191 -0.20 LYS 379

LYS 422 0.39 PRO 192 -0.22 LYS 379

LYS 422 0.38 HIS 193 -0.20 LYS 379

LYS 422 0.34 VAL 194 -0.21 LYS 379

ASP 423 0.37 LEU 195 -0.24 LYS 379

ASP 423 0.41 THR 196 -0.26 LEU 602

ASP 423 0.45 PRO 197 -0.29 LYS 379

ASP 423 0.41 PHE 198 -0.30 LYS 379

ASP 423 0.37 VAL 199 -0.28 PHE 387

ASP 423 0.40 GLU 200 -0.28 LYS 379

ASP 423 0.40 GLU 201 -0.31 LYS 379

ASP 423 0.36 CYS 202 -0.31 PHE 387

ASP 423 0.34 LEU 203 -0.29 PHE 387

ASP 423 0.34 VAL 204 -0.30 ARG 383

ASP 423 0.32 ALA 205 -0.33 PHE 387

ASP 423 0.30 ALA 206 -0.31 PHE 387

ASP 423 0.29 ALA 207 -0.29 PHE 387

ASP 423 0.29 GLY 208 -0.31 PHE 387

ASP 423 0.28 GLY 209 -0.33 PHE 387

ASP 423 0.25 THR 210 -0.32 PHE 387

ASP 423 0.26 THR 211 -0.32 ARG 383

ASP 423 0.26 SER 212 -0.30 ARG 383

ASP 423 0.28 HIS 213 -0.30 ARG 383

ASP 423 0.26 GLN 214 -0.27 ARG 383

ASP 423 0.26 VAL 215 -0.26 ARG 383

ASP 423 0.23 SER 216 -0.24 PHE 387

ASP 423 0.23 PHE 217 -0.21 ARG 383

ASP 423 0.21 SER 218 -0.21 PHE 387

ASP 423 0.23 TYR 219 -0.24 PHE 387

ASP 423 0.25 PHE 220 -0.22 PHE 387

LYS 422 0.22 ASN 221 -0.20 PHE 387

ASP 423 0.22 GLY 222 -0.21 PHE 387

ASP 423 0.25 PHE 223 -0.23 PHE 387

LYS 422 0.25 ASN 224 -0.20 PHE 387

LYS 422 0.21 SER 225 -0.19 PHE 387

ASP 423 0.22 LEU 226 -0.21 PHE 387

ASP 423 0.26 LEU 227 -0.21 PHE 387

LYS 422 0.24 ASN 228 -0.17 PHE 387

LYS 422 0.20 ASN 229 -0.17 PHE 387

GLY 424 0.22 MET 230 -0.20 LEU 602

GLY 424 0.18 GLU 231 -0.18 LEU 602

GLY 424 0.15 LEU 232 -0.16 TRP 606

ASN 513 0.18 ILE 233 -0.20 TRP 606

ASN 513 0.20 ARG 234 -0.24 TRP 606

ASN 513 0.18 LYS 235 -0.20 TRP 606

ASN 513 0.20 ILE 236 -0.20 TRP 606

ASN 513 0.26 TYR 237 -0.27 TRP 606

ASN 513 0.25 SER 238 -0.28 TRP 606

ASN 513 0.23 THR 239 -0.19 TRP 606

ASN 513 0.26 LEU 240 -0.24 TRP 606

ASN 513 0.30 ALA 241 -0.33 TRP 606

SER 519 0.25 GLY 242 -0.29 PHE 607

SER 519 0.30 THR 243 -0.43 TRP 606

SER 519 0.37 ARG 244 -0.58 TRP 606

SER 519 0.42 LYS 245 -0.55 TRP 606

ASN 513 0.44 ASP 246 -0.50 TRP 606

ASN 513 0.38 VAL 247 -0.45 TRP 606

ASN 513 0.37 GLU 248 -0.37 TRP 606

ASN 513 0.31 VAL 249 -0.32 PHE 387

ASN 513 0.29 THR 250 -0.33 PHE 387

ASN 513 0.26 LYS 251 -0.30 PHE 387

ASN 513 0.24 GLU 252 -0.28 PHE 387

ASN 513 0.25 GLU 253 -0.27 PHE 387

ASN 513 0.24 PHE 254 -0.25 PHE 387

ASN 513 0.21 VAL 255 -0.23 PHE 387

ASN 513 0.20 LEU 256 -0.24 PHE 414

ASN 513 0.20 ALA 257 -0.21 PHE 414

ASN 513 0.18 ALA 258 -0.20 PHE 414

ASN 513 0.16 GLN 259 -0.24 ASP 417

ASN 513 0.15 LYS 260 -0.24 ASP 417

ASN 513 0.14 PHE 261 -0.21 ASP 417

LEU 602 0.14 GLY 262 -0.24 LYS 422

LEU 602 0.12 GLN 263 -0.20 ASP 417

ASP 423 0.14 VAL 264 -0.18 LYS 418

ASP 423 0.15 THR 265 -0.20 PHE 387

ASP 423 0.17 PRO 266 -0.23 PHE 387

ASP 423 0.19 MET 267 -0.24 PHE 387

ASP 423 0.20 GLU 268 -0.23 PHE 387

ASP 423 0.20 VAL 269 -0.25 PHE 387

ASP 423 0.22 ASP 270 -0.28 PHE 387

ASP 423 0.25 ILE 271 -0.27 PHE 387

ASP 423 0.25 LEU 272 -0.28 PHE 387

GLU 514 0.26 PHE 273 -0.31 PHE 387

ASP 423 0.26 GLN 274 -0.32 PHE 387

ASP 423 0.30 LEU 275 -0.32 PHE 387

GLU 514 0.30 ALA 276 -0.34 PHE 387

GLU 514 0.30 ASP 277 -0.37 PHE 387

ASP 423 0.32 LEU 278 -0.37 PHE 387

ASP 423 0.35 TYR 279 -0.38 PHE 387

GLU 514 0.37 GLU 280 -0.42 PHE 387

GLU 514 0.33 PRO 281 -0.42 PHE 387

GLU 514 0.35 ARG 282 -0.43 PHE 387

GLU 514 0.30 GLY 283 -0.39 PHE 387

ASN 513 0.33 ARG 284 -0.37 PHE 387

ASN 513 0.33 MET 285 -0.34 PHE 387

ASN 513 0.38 THR 286 -0.38 TRP 606

ASN 513 0.37 LEU 287 -0.38 TRP 606

GLU 514 0.44 ALA 288 -0.42 LEU 602

GLU 514 0.36 ASP 289 -0.35 LEU 602

GLU 514 0.29 ILE 290 -0.31 LEU 602

GLY 424 0.32 GLU 291 -0.34 LEU 602

ASP 423 0.36 ARG 292 -0.33 LEU 602

ASP 423 0.33 ILE 293 -0.28 LEU 602

ASP 423 0.31 ALA 294 -0.26 LEU 602

ASP 423 0.34 PRO 295 -0.24 LEU 602

ASP 423 0.38 LEU 296 -0.25 LEU 602

LYS 422 0.34 GLU 297 -0.21 LEU 602

LYS 422 0.41 GLU 298 -0.20 SER 519

LYS 422 0.36 GLY 299 -0.17 LEU 602

ASP 417 0.32 THR 300 -0.16 SER 519

LYS 422 0.41 LEU 301 -0.21 SER 519

ASP 417 0.38 PRO 302 -0.22 ASP 515

ASP 417 0.34 PHE 303 -0.18 GLY 516

ASP 417 0.38 ASN 304 -0.21 VAL 622

ASP 417 0.46 LEU 305 -0.30 GLY 516

ASP 417 0.40 ALA 306 -0.25 GLY 516

PHE 414 0.37 GLU 307 -0.22 GLY 516

ASP 417 0.46 ALA 308 -0.31 GLY 516

PHE 414 0.47 GLN 309 -0.31 GLY 516

PHE 414 0.41 ARG 310 -0.24 GLY 516

PHE 414 0.43 GLN 311 -0.25 MET 617

PHE 414 0.56 LYS 312 -0.32 MET 617

PHE 414 0.51 ALA 313 -0.36 ASP 423

THR 410 0.44 SER 314 -0.40 ASP 423

THR 410 0.55 GLY 315 -0.48 GLY 424

THR 410 0.48 ASP 316 -0.71 GLY 424

LYS 10 0.35 SER 317 -0.63 ASP 423

LYS 10 0.33 ALA 318 -0.60 GLY 424

ALA 7 0.28 ARG 319 -0.52 GLY 424

LYS 10 0.26 PRO 320 -0.53 GLY 424

LEU 399 0.32 VAL 321 -0.63 GLY 424

LEU 471 0.28 LEU 322 -0.52 GLY 424

LYS 5 0.25 LEU 323 -0.42 GLY 424

LEU 399 0.25 GLN 324 -0.47 GLY 424

LEU 399 0.30 VAL 325 -0.47 GLY 424

LEU 471 0.24 ALA 326 -0.45 TRP 606

TYR 330 0.21 GLU 327 -0.38 TRP 606

ALA 402 0.27 SER 328 -0.35 GLY 424

GLY 333 0.33 ALA 329 -0.43 TRP 606

ALA 329 0.23 TYR 330 -0.49 TRP 606

GLY 315 0.18 ARG 331 -0.34 TRP 606

GLY 315 0.25 PHE 332 -0.37 TRP 606

ALA 329 0.33 GLY 333 -0.42 TRP 606

PRO 403 0.22 LEU 334 -0.31 TRP 606

PHE 479 0.20 GLY 335 -0.27 TRP 606

GLY 339 0.22 SER 336 -0.31 TRP 606

PRO 403 0.27 VAL 337 -0.26 ASP 246

PRO 403 0.30 ALA 338 -0.26 ASP 246

PHE 479 0.26 GLY 339 -0.20 ASP 246

PHE 479 0.29 ALA 340 -0.26 ASP 246

PRO 403 0.36 VAL 341 -0.33 ASP 246

PHE 445 0.32 GLY 342 -0.27 ASP 246

PHE 479 0.33 ALA 343 -0.25 GLU 280

PHE 479 0.39 THR 344 -0.32 ARG 282

PHE 479 0.41 ALA 345 -0.36 GLU 280

PHE 479 0.39 VAL 346 -0.30 GLU 280

PHE 479 0.40 TYR 347 -0.29 GLU 280

PHE 479 0.45 PRO 348 -0.32 GLU 280

PHE 479 0.40 ILE 349 -0.29 GLU 280

PHE 479 0.36 ASP 350 -0.24 GLU 280

PHE 479 0.40 LEU 351 -0.26 GLU 280

PHE 479 0.41 VAL 352 -0.27 GLU 280

PHE 479 0.36 LYS 353 -0.22 GLU 280

PHE 479 0.33 THR 354 -0.21 PHE 387

PHE 479 0.37 ARG 355 -0.23 GLU 280

PHE 479 0.36 MET 356 -0.21 GLU 280

PHE 479 0.31 GLN 357 -0.22 PHE 387

PHE 479 0.31 ASN 358 -0.22 PHE 387

PHE 479 0.33 GLN 359 -0.19 PHE 387

PHE 479 0.30 ARG 360 -0.22 GLY 386

PHE 479 0.30 SER 361 -0.20 GLY 386

PHE 479 0.27 THR 362 -0.21 GLY 386

PHE 479 0.27 GLY 363 -0.20 GLY 386

PHE 479 0.27 SER 364 -0.19 GLY 386

PHE 479 0.30 PHE 365 -0.18 GLU 280

PHE 479 0.33 VAL 366 -0.20 GLU 280

PHE 479 0.34 GLY 367 -0.21 GLU 280

PHE 479 0.39 GLU 368 -0.24 GLU 280

PHE 479 0.38 LEU 369 -0.23 GLU 280

PHE 479 0.42 MET 370 -0.26 GLU 280

PHE 479 0.42 TYR 371 -0.27 GLU 280

PHE 479 0.41 LYS 372 -0.26 GLU 280

PHE 479 0.41 ASN 373 -0.27 GLU 280

PHE 479 0.42 SER 374 -0.28 GLU 280

PHE 479 0.46 PHE 375 -0.33 GLU 280

PHE 479 0.47 ASP 376 -0.33 GLU 280

PHE 479 0.47 CYS 377 -0.31 GLU 280

PHE 479 0.50 PHE 378 -0.35 GLU 280

PHE 479 0.55 LYS 379 -0.38 GLU 280

PHE 479 0.54 LYS 380 -0.35 GLU 280

PHE 479 0.56 VAL 381 -0.35 GLU 280

PHE 479 0.62 LEU 382 -0.40 GLU 280

PHE 479 0.64 ARG 383 -0.40 GLU 280

PHE 479 0.62 TYR 384 -0.36 ARG 282

PHE 479 0.64 GLU 385 -0.37 ARG 282

PHE 479 0.71 GLY 386 -0.41 ARG 282

PHE 479 0.69 PHE 387 -0.43 ARG 282

PHE 479 0.67 PHE 388 -0.40 ARG 282

PHE 479 0.60 GLY 389 -0.36 ARG 282

PHE 479 0.54 LEU 390 -0.35 ARG 282

PHE 479 0.50 TYR 391 -0.34 ARG 282

PHE 479 0.46 ARG 392 -0.31 ARG 282

PHE 479 0.36 GLY 393 -0.27 ARG 282

PHE 479 0.37 LEU 394 -0.28 ARG 282

PHE 479 0.30 LEU 395 -0.28 LEU 322

VAL 321 0.26 PRO 396 -0.27 PHE 387

PHE 479 0.25 GLN 397 -0.25 PHE 387

PHE 479 0.25 LEU 398 -0.24 VAL 247

VAL 321 0.32 LEU 399 -0.28 PHE 387

GLY 315 0.28 GLY 400 -0.35 PHE 387

GLY 315 0.25 VAL 401 -0.28 PHE 387

GLY 315 0.31 ALA 402 -0.30 LEU 602

GLY 315 0.38 PRO 403 -0.39 PHE 387

GLY 315 0.33 GLU 404 -0.37 PHE 387

GLY 315 0.31 LYS 405 -0.31 PHE 387

GLY 315 0.44 ALA 406 -0.36 LEU 602

GLY 315 0.46 ILE 407 -0.42 PHE 387

MET 617 0.36 LYS 408 -0.36 PHE 387

MET 617 0.45 LEU 409 -0.34 LEU 602

GLY 315 0.55 THR 410 -0.39 LEU 602

PRO 634 0.45 VAL 411 -0.41 PHE 387

MET 617 0.42 ASN 412 -0.35 PHE 387

MET 617 0.51 ASP 413 -0.42 VAL 325

PRO 634 0.59 PHE 414 -0.40 VAL 595

PRO 634 0.55 VAL 415 -0.38 LYS 379

PRO 632 0.53 ARG 416 -0.43 VAL 321

PRO 634 0.69 ASP 417 -0.56 VAL 321

PRO 634 0.76 LYS 418 -0.44 VAL 321

PRO 634 0.66 PHE 419 -0.43 VAL 321

ALA 631 0.73 MET 420 -0.53 VAL 321

ALA 631 0.81 HIS 421 -0.53 VAL 321

ALA 631 1.03 LYS 422 -0.59 VAL 321

ALA 631 0.98 ASP 423 -0.70 ASP 316

ALA 631 0.85 GLY 424 -0.71 ASP 316

ALA 631 0.62 SER 425 -0.55 ASP 316

ALA 631 0.53 VAL 426 -0.46 VAL 321

ALA 631 0.44 PRO 427 -0.39 VAL 321

PRO 675 0.35 LEU 428 -0.33 VAL 321

PRO 675 0.36 ALA 429 -0.31 LYS 379

ALA 631 0.44 ALA 430 -0.33 VAL 321

ALA 631 0.35 GLU 431 -0.32 VAL 321

PRO 675 0.31 ILE 432 -0.31 PHE 387

ALA 631 0.35 LEU 433 -0.35 PHE 387

PRO 634 0.38 ALA 434 -0.35 PHE 387

MET 617 0.29 GLY 435 -0.33 PHE 387

PRO 634 0.30 GLY 436 -0.37 PHE 387

PRO 634 0.39 CYS 437 -0.41 PHE 387

PRO 634 0.35 ALA 438 -0.39 PHE 387

PRO 634 0.28 GLY 439 -0.38 PHE 387

PRO 634 0.33 GLY 440 -0.44 PHE 387

PRO 634 0.37 SER 441 -0.48 PHE 387

GLY 315 0.33 GLN 442 -0.44 PHE 387

GLU 16 0.31 VAL 443 -0.46 PHE 387

GLU 16 0.37 ILE 444 -0.54 PHE 387

ASP 316 0.36 PHE 445 -0.52 PHE 387

GLY 315 0.29 THR 446 -0.43 PHE 387

ALA 15 0.29 ASN 447 -0.45 PHE 387

ALA 15 0.31 PRO 448 -0.48 PHE 387

ASP 13 0.28 LEU 449 -0.40 PHE 387

ALA 15 0.24 GLU 450 -0.35 PHE 387

ALA 15 0.25 ILE 451 -0.37 PHE 387

ALA 15 0.25 VAL 452 -0.34 PHE 387

PHE 479 0.27 LYS 453 -0.27 PHE 387

PHE 479 0.28 ILE 454 -0.27 PHE 387

PHE 479 0.27 ARG 455 -0.27 PHE 387

PHE 479 0.33 LEU 456 -0.25 ARG 282

PHE 479 0.38 GLN 457 -0.25 ARG 282

PHE 479 0.36 VAL 458 -0.24 ARG 282

PHE 479 0.37 ALA 459 -0.26 ARG 282

PHE 479 0.46 GLY 460 -0.29 ARG 282

PHE 479 0.45 GLU 461 -0.28 ARG 282

PHE 479 0.42 ILE 462 -0.27 ARG 282

PHE 479 0.49 THR 463 -0.30 ARG 282

GLY 478 0.43 THR 464 -0.29 ARG 282

GLY 478 0.36 GLY 465 -0.27 ARG 282

GLY 478 0.33 PRO 466 -0.27 ARG 282

GLY 478 0.39 ARG 467 -0.29 ARG 282

GLY 478 0.29 VAL 468 -0.26 ARG 282

ARG 475 0.26 SER 469 -0.29 VAL 321

VAL 321 0.27 ALA 470 -0.28 LEU 322

ALA 15 0.30 LEU 471 -0.35 PHE 388

ALA 15 0.28 SER 472 -0.32 PHE 388

ALA 15 0.28 VAL 473 -0.36 PHE 388

ALA 15 0.32 VAL 474 -0.47 PHE 388

ALA 15 0.33 ARG 475 -0.48 PHE 388

ALA 15 0.31 ASP 476 -0.44 GLY 386

ALA 15 0.31 LEU 477 -0.49 GLY 386

ALA 15 0.35 GLY 478 -0.59 GLY 386

ALA 15 0.39 PHE 479 -0.67 GLY 386

ALA 15 0.37 PHE 480 -0.63 GLY 386

ALA 15 0.33 GLY 481 -0.54 GLY 386

ALA 15 0.33 ILE 482 -0.52 PHE 387

ALA 15 0.33 TYR 483 -0.53 PHE 387

ALA 15 0.29 LYS 484 -0.48 GLY 386

ALA 15 0.26 GLY 485 -0.43 PHE 387

GLU 16 0.29 ALA 486 -0.47 PHE 387

GLU 16 0.28 LYS 487 -0.45 PHE 387

GLU 16 0.22 ALA 488 -0.39 PHE 387

GLU 16 0.23 CYS 489 -0.39 PHE 387

GLU 16 0.26 PHE 490 -0.42 PHE 387

PRO 675 0.23 LEU 491 -0.38 PHE 387

PRO 675 0.21 ARG 492 -0.34 PHE 387

PRO 675 0.21 ASP 493 -0.35 PHE 387

PRO 675 0.25 ILE 494 -0.37 PHE 387

PRO 675 0.25 PRO 495 -0.33 PHE 387

PRO 675 0.22 PHE 496 -0.30 PHE 387

PRO 675 0.24 SER 497 -0.31 PHE 387

PRO 675 0.26 ALA 498 -0.31 PHE 387

PRO 675 0.25 ILE 499 -0.27 PHE 387

PRO 675 0.23 TYR 500 -0.25 PHE 387

PRO 675 0.25 PHE 501 -0.26 PHE 387

PRO 675 0.28 PRO 502 -0.26 VAL 321

PRO 675 0.25 CYS 503 -0.22 VAL 321

PRO 675 0.23 TYR 504 -0.22 VAL 321

PRO 675 0.26 ALA 505 -0.29 VAL 321

PRO 675 0.27 HIS 506 -0.28 ASP 316

LYS 422 0.24 VAL 507 -0.23 ASP 316

ASP 246 0.24 LYS 508 -0.25 ASP 316

ASP 246 0.29 ALA 509 -0.32 ASP 316

ASP 246 0.32 SER 510 -0.35 PRO 634

ASP 246 0.36 PHE 511 -0.34 ALA 631

ASP 246 0.37 ALA 512 -0.34 PRO 632

ASP 246 0.44 ASN 513 -0.40 ALA 631

ALA 288 0.44 GLU 514 -0.52 ALA 631

ALA 288 0.41 ASP 515 -0.41 ALA 631

GLY 424 0.35 GLY 516 -0.36 PRO 632

ASP 246 0.36 GLN 517 -0.30 SER 519

LYS 245 0.39 VAL 518 -0.25 ALA 631

LYS 245 0.42 SER 519 -0.37 LYS 624

PRO 320 0.33 PRO 520 -0.30 LYS 624

PRO 320 0.39 GLY 521 -0.31 LYS 624

PRO 320 0.34 SER 522 -0.27 ALA 631

LYS 422 0.27 LEU 523 -0.18 ALA 631

PHE 414 0.31 LEU 524 -0.21 SER 590

LYS 418 0.33 LEU 525 -0.23 SER 590

LYS 418 0.28 ALA 526 -0.19 ALA 631

LYS 418 0.26 GLY 527 -0.16 PHE 387

LYS 418 0.31 ALA 528 -0.17 LEU 525

LYS 418 0.30 ILE 529 -0.17 ALA 631

LYS 418 0.25 ALA 530 -0.19 PHE 387

LYS 418 0.26 GLY 531 -0.20 PHE 387

LYS 418 0.29 MET 532 -0.18 PHE 387

LYS 418 0.26 PRO 533 -0.20 PHE 387

LYS 418 0.22 ALA 534 -0.24 PHE 387

PHE 479 0.24 ALA 535 -0.23 PHE 387

LYS 418 0.26 SER 536 -0.21 PHE 387

LYS 418 0.22 LEU 537 -0.25 PHE 387

PHE 479 0.21 VAL 538 -0.28 PHE 387

PHE 479 0.24 THR 539 -0.25 PHE 387

PHE 479 0.22 PRO 540 -0.28 PHE 387

PHE 479 0.20 ALA 541 -0.31 PHE 387

PHE 479 0.23 ASP 542 -0.29 PHE 387

PHE 479 0.25 VAL 543 -0.28 PHE 387

PHE 479 0.21 ILE 544 -0.32 PHE 387

PHE 479 0.20 LYS 545 -0.34 PHE 387

PHE 479 0.24 THR 546 -0.30 PHE 387

PHE 479 0.23 ARG 547 -0.30 GLY 386

ALA 15 0.21 LEU 548 -0.36 GLY 386

ALA 15 0.23 GLN 549 -0.36 PHE 387

PHE 479 0.23 VAL 550 -0.31 GLY 386

ALA 15 0.22 ALA 551 -0.31 GLY 386

PHE 479 0.21 ALA 552 -0.31 GLY 386

PHE 479 0.25 ARG 553 -0.26 GLY 386

PHE 479 0.22 ALA 554 -0.26 GLY 386

PHE 479 0.22 GLY 555 -0.26 GLY 386

PHE 479 0.23 GLN 556 -0.27 GLY 386

PHE 479 0.20 THR 557 -0.30 GLY 386

ALA 15 0.21 THR 558 -0.35 GLY 386

ALA 15 0.22 TYR 559 -0.37 GLY 386

ALA 15 0.26 SER 560 -0.42 GLY 386

ALA 15 0.25 GLY 561 -0.42 GLY 386

GLU 16 0.22 VAL 562 -0.39 GLY 386

PRO 675 0.22 ILE 563 -0.38 GLY 386

ALA 15 0.20 ASP 564 -0.37 GLY 386

ALA 15 0.18 CYS 565 -0.35 GLY 386

PRO 675 0.18 PHE 566 -0.33 GLY 386

PRO 675 0.19 ARG 567 -0.32 GLY 386

PHE 479 0.19 LYS 568 -0.31 GLY 386

PHE 479 0.22 ILE 569 -0.28 GLY 386

PHE 479 0.21 LEU 570 -0.27 GLY 386

PHE 479 0.20 ARG 571 -0.27 GLY 386

PHE 479 0.23 GLU 572 -0.26 GLY 386

PHE 479 0.25 GLU 573 -0.23 GLY 386

PHE 479 0.24 GLY 574 -0.24 GLY 386

PHE 479 0.24 PRO 575 -0.24 GLY 386

PHE 479 0.27 LYS 576 -0.21 GLY 386

PHE 479 0.27 ALA 577 -0.22 GLY 386

PHE 479 0.25 LEU 578 -0.25 PHE 387

PHE 479 0.27 TRP 579 -0.22 PHE 387

PHE 479 0.30 LYS 580 -0.20 PHE 387

PHE 479 0.32 GLY 581 -0.18 PHE 387

PHE 479 0.29 ALA 582 -0.19 PHE 387

LYS 418 0.32 GLY 583 -0.17 GLU 201

PHE 479 0.34 ALA 584 -0.20 GLU 280

PHE 479 0.31 ARG 585 -0.18 PHE 387

LYS 418 0.31 VAL 586 -0.17 LEU 525

PHE 414 0.35 PHE 587 -0.21 TYR 279

PHE 479 0.33 ARG 588 -0.21 GLU 280

PHE 414 0.30 SER 589 -0.17 PHE 387

PHE 414 0.34 SER 590 -0.23 LEU 525

PHE 414 0.38 PRO 591 -0.24 TYR 279

PHE 414 0.33 GLN 592 -0.22 GLU 280

PHE 414 0.31 PHE 593 -0.17 LYS 624

PHE 414 0.37 GLY 594 -0.26 LYS 624

PHE 414 0.39 VAL 595 -0.29 ALA 288

PHE 414 0.32 THR 596 -0.23 ALA 288

PHE 414 0.31 LEU 597 -0.22 ALA 288

PHE 414 0.38 LEU 598 -0.33 ALA 288

THR 410 0.37 THR 599 -0.34 ASP 246

THR 410 0.30 TYR 600 -0.26 ALA 288

ALA 326 0.33 GLU 601 -0.32 ALA 288

ALA 326 0.43 LEU 602 -0.46 ASP 246

GLY 333 0.34 LEU 603 -0.36 ASP 246

TYR 330 0.30 GLN 604 -0.29 ASP 246

ALA 326 0.40 ARG 605 -0.47 LYS 245

TYR 330 0.51 TRP 606 -0.58 ARG 244

GLY 333 0.38 PHE 607 -0.44 ARG 244

TYR 330 0.30 TYR 608 -0.31 THR 243

ALA 2 0.23 ILE 609 -0.29 THR 243

GLY 333 0.18 ASP 610 -0.18 SER 519

ALA 4 0.20 PHE 611 -0.27 ARG 605

ALA 4 0.18 GLY 612 -0.26 MET 1

ALA 406 0.24 GLY 613 -0.26 GLY 424

THR 410 0.34 VAL 614 -0.23 GLY 424

THR 410 0.29 LYS 615 -0.17 GLY 521

THR 410 0.39 PRO 616 -0.23 ALA 509

ASP 413 0.51 MET 617 -0.32 LYS 312

ASP 413 0.36 GLY 618 -0.23 LYS 312

LYS 245 0.25 SER 619 -0.19 SER 519

ASP 413 0.28 GLU 620 -0.23 SER 519

GLY 424 0.31 PRO 621 -0.33 SER 519

GLY 424 0.45 VAL 622 -0.26 LEU 305

GLY 424 0.42 PRO 623 -0.24 SER 519

GLY 424 0.56 LYS 624 -0.37 SER 519

GLY 424 0.55 SER 625 -0.30 SER 519

ASP 423 0.58 ARG 626 -0.29 SER 519

ASP 423 0.60 ILE 627 -0.26 SER 519

ASP 423 0.73 ASN 628 -0.35 GLU 514

LYS 422 0.75 LEU 629 -0.37 GLU 514

LYS 422 0.86 PRO 630 -0.41 GLU 514

LYS 422 1.03 ALA 631 -0.52 GLU 514

LYS 422 0.97 PRO 632 -0.47 GLU 514

LYS 422 0.92 ASN 633 -0.41 GLU 514

LYS 422 0.90 PRO 634 -0.40 GLU 514

LYS 422 0.69 ASP 635 -0.34 GLU 514

LYS 422 0.62 HIS 636 -0.34 GLU 514

LYS 418 0.58 VAL 637 -0.31 GLU 514

LYS 418 0.49 GLY 638 -0.27 GLU 514

LYS 418 0.44 GLY 639 -0.25 GLU 514

LYS 418 0.49 TYR 640 -0.28 GLU 514

LYS 418 0.54 LYS 641 -0.33 GLU 514

LYS 418 0.47 LEU 642 -0.28 GLU 514

LYS 422 0.47 ALA 643 -0.27 GLU 514

LYS 422 0.57 VAL 644 -0.29 GLU 514

LYS 422 0.52 ALA 645 -0.27 GLU 514

LYS 422 0.42 THR 646 -0.21 GLU 514

LYS 422 0.45 PHE 647 -0.21 GLU 514

LYS 422 0.49 ALA 648 -0.21 GLU 514

LYS 422 0.41 GLY 649 -0.18 SER 519

LYS 422 0.37 ILE 650 -0.15 SER 519

LYS 422 0.41 GLU 651 -0.16 SER 519

LYS 422 0.40 ASN 652 -0.17 PHE 375

LYS 422 0.33 LYS 653 -0.15 PHE 375

LYS 422 0.32 PHE 654 -0.15 PHE 375

LYS 422 0.35 GLY 655 -0.17 PHE 375

LYS 422 0.37 LEU 656 -0.16 PHE 375

LYS 422 0.42 TYR 657 -0.18 PHE 375

LYS 422 0.43 LEU 658 -0.17 PHE 375

LYS 422 0.45 PRO 659 -0.19 PHE 375

LYS 422 0.51 LEU 660 -0.19 PHE 375

LYS 422 0.51 PHE 661 -0.20 PHE 375

LYS 422 0.47 LYS 662 -0.20 PHE 375

LYS 422 0.44 PRO 663 -0.21 PHE 375

LYS 422 0.44 SER 664 -0.22 PHE 375

LYS 422 0.41 VAL 665 -0.21 PHE 375

LYS 422 0.40 SER 666 -0.22 PHE 375

LYS 422 0.39 THR 667 -0.21 PHE 375

LYS 422 0.37 SER 668 -0.20 LYS 379

LYS 422 0.38 LYS 669 -0.19 LYS 379

LYS 422 0.37 ALA 670 -0.18 LYS 379

LYS 422 0.37 ILE 671 -0.17 LYS 379

LYS 422 0.35 GLY 672 -0.17 LYS 379

LYS 422 0.35 GLY 673 -0.13 LYS 379

LYS 422 0.43 GLY 674 -0.10 ARG 383

ASP 423 0.46 PRO 675 -0.08 GLU 141

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: April 25th, 2023.

Should you encounter any unexpected behaviour, please let us know.

*** r191c ***

CA distance fluctuations for 240323151426237850

--- normal mode 14 ---

Should you encounter any unexpected behaviour,
please let us know.

* r191c *