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Youri Timsit

Directeur de Recherche CNRS

Tel : +33 4 91 82 54 27


Etude structurale des macromolécules biologiques par cristallographie des rayons-X.

1. Reconaissance ADN-ADN. Structure et stabilité des croisements d’ADN, implications pour le mécanisme d’action des topoisomérases II, la recombinaison et l’assemblage de la chromatine

2. Activité de l’ADN dans les phases condensées

3. Rôle de la structure de l’ADN dans la fidélité de la réplication et la mutagénèse

4. Rôle des protéines ribosomiques dans l’assemblage du ribosome

5. Structures de l’ARN et sites fixations des ions

Publications :

Timsit, Y., Westhof, E., Fuchs, R & Moras. D. Unusual helical packing in crystals of DNA bearing a mutation hot spot. (1989) Nature 341, 459-462

Timsit, Y. & Moras, D. Groove-backbone interaction in B-DNA. Implication for DNA condensation and recombination. (1991) J. Mol. Biol. 221, 919-940.

Timsit, Y., Vilbois, E. & Moras, D. Base pairing shift in the major groove of (CA)n tracts by B-DNA crystal structures. (1991) Nature 354, 167-170.

Timsit, Y. & Moras, D. (1992). Crystallization of DNA. Meth. in Enzymology 211, 409-429.

Timsit, Y. & Moras, D. (1994). DNA self-fitting : the double helix directs the geometry of its supramolecular assemblies. EMBO J. 13, 2737-2746.

Timsit, Y. & Moras, D. (1995). Self-fitting and self-modifying properties of the B-DNA molecule. J.Mol. Biol. 251, 629-647.

Timsit, Y. & Moras, D. (1995). DNA self-fitting. In Proceeding of the nine conversation, state university of New York, Albany, eds R. Sarma and M. Sarma, Adenine press.

Timsit, Y. & Moras, D. (1996). Cruciform structures and functions. Q. Rev. Biophys. 29, 279-307.

Mayer-Jung, C., Moras, D. & Timsit, Y. (1997). Effect of cytosine methylation on DNA-DNA recognition at CpG steps J. Mol. Biol. 270, 328-335.

Mayer-Jung, C., Moras, D. & Timsit, Y. (1998) Hydration and recognition of methylated CpG steps in DNA. EMBO J. 17, 2709-2718.

Timsit, Y., Duplantier, B., Jannink, G. & Sikorav, J.L (1998). Symmetry and chirality in topoisomerase II-DNA crossover recognition. J. Mol. Biol. 284, 1289-1299.

Sikorav, J.L., Duplantier, B., Jannink, G. & Timsit, Y. (1998). Recognition of crossover by type II topoisomerases. A thermodynamic study. J. Mol. Biol. 284, 1279-1287.

Timsit, Y., Shatzky-Schwartz, M., & Shakked, Z. (1999). Left-handed DNA crossovers. Implications for DNA-DNA recognition and structural alterations. J. Biomolec. Struct. Dyn. 16, 775-786.

Timsit, Y. (1999). DNA structure and polymerase fidelity. J. Mol. Biol. 293, 835-853.

Timsit, Y. (2000). Polymerase fidelity : a new role for A-DNA. Proceeding of the eleventh conversation, state university of New York, Albany, eds R. Sarma and M. Sarma, Adenine press.

Mayer, C. and Timsit, Y. (2001). Hydratation and structural alteration of A-DNA. Implication for the accuracy of DNA replication. Mol. Cell. Biol. 47, 815-822.

Timsit, Y. (2001). Convergent evolution of MutS and Topoisomerase II for clamping DNA crossovers and stacked Holliday junctions J. Biomolec. Struct. Dyn. 19, 215-218.

Timsit, Y., Allemand, F., Chiaruttini, C., & Springer, M. (2006). Coexistence of two protein folding states in the crystal structure of ribosomal protein L20. EMBO reports 7, 1013-1018.

Timsit, Y. & Bombard, S. (2007). The 1. 3 Å resolution structure of the RNA tridecamer r(GCGUUUGAAACGC) : metal ion binding correlates with base unstacking and groove contraction. RNA 13, 1-10.

Timsit, Y., Acosta, Z., Allemand, F., Chiaruttini, C., & Springer, M. (2009). The Role of Disordered Ribosomal Protein Extensions in the Early Steps of Eubacterial 50 S Ribosomal Subunit Assembly. Int. J. Mol. Sci. 10, 817-834

Timsit, Y., Allemand, F., Chiaruttini, C., Springer, M. (2009). “Order-disorder transitions in ribosome assembly”, dans Ribosomal proteins and protein engineering design, selection and Applications V. Ortendhal and H. Salchow (Ed.) Nova publishers, Hauppauge N.Y.

  1. Poirot O, Timsit Y (2016) Neuron-Like Networks Between Ribosomal Proteins Within the Ribosome. Sci Rep.6 ;:26485,2016  - PMID:27225526

  2. Timsit Y (2013) DNA self-assembly: from chirality to evolution. Int J Mol Sci.14 ;4:8252-70,2013  - PMID:23591841

  3. Timsit Y (2012) DNA-directed base pair opening Molecules.17 ;10:11947-64,2012 - PMID:23060287

  4. Timsit Y (2011) DNA-DNA recognition: from tight contact to fatal attraction. Molecular Interaction, INTECH open access publisher. in press,2011 Dec

  5. Timsit Y (2011) Local sensing of global DNA topology: from crossover geometry to type II topoisomerase processivity. Nucleic Acids Res.39 ;20:8665-76,2011 Nov 1 - PMID:21764774

  6. Timsit Y, Varnai P (2011) Cytosine, the double helix and DNA self-assembly. J Mol Recognit.24 ;2:137-8,  - PMID:21360605

  7. Timsit Y, Varnai P (2010) Helical Chirality: a Link between Local Interactions and Global Topology in DNA. PLoS One.5 ;2:e9326,2010  - PMID:20174470

  8. Varnai P, Timsit Y (2010) Differential stability of DNA crossovers in solution mediated by divalent cations. Nucleic Acids Res.38 ;12:4163-72,2010 Jul 1 - PMID:20215439

  9. Timsit Y, Allemand F, Chiaruttini C, Springer M (2010) Order-disorder transitions in ribosome assembly Ribosomal proteins and protein engineering design, selection and Applications V. Ortendhal and H. Salchow (Ed.) Nova publishers, Hauppauge N.Y.,2010