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Chantal Abergel

Directeur de Recherche CNRS

Tel : +33 4 91 82 54 22


The structural team is currently focusing on large DNA viruses such as Mimivirus and PBCV. A comprehensive structural and functional study of selected genes products was initiated, as they may hold important clues about the origin of DNA viruses and on the mecanisms used by viruses to highjack the host cell to its own benefit.

We first focused on genes seen for the first time in a virus such as enzymes involved in translation and DNA metabolism. We are now interested in genes conserved in large DNA viruses. Analyzing them is a great opportunity to discover new “entry” points (molecular switches) in the control of cell death (apoptosis), cell division (DNA replication), or bacterial infection (phagocytosis, cell trafficking). This in turn might lead to innovative therapeutic approaches.

We produce our protein targets using a standard protocol based on incomplete factorial design (Abergel et al., 2003, J Struct Funct Genomics ; 4:141-57). Activity measurement are performed using spectroscopique techniques every time possible or in collaboration with specialized laboratories. For each project we try to solve the structure of the protein of interest alone and in complex with predicted ligands or interactors.

The next step of our study is to produce these genes in vivo, study the physiological impact of their expression as well as their localization depending on the infectious stage of the host.

  1. Ekeberg T, Svenda M, Seibert MM, Abergel C, Maia FR, Seltzer V, DePonte DP, Aquila A, Andreasson J, Iwan B, Jonsson O, Westphal D, Odic D, Andersson I, Barty A, Liang M, Martin AV, Gumprecht L, Fleckenstein H, Bajt S, Barthelmess M, Coppola N, Claverie JM, Loh ND, Bostedt C, Bozek JD, Krzywinski J, Messerschmidt M, Bogan MJ, Hampton CY, Sierra RG, Frank M, Shoeman RL, Lomb L, Foucar L, Epp SW, Rolles D, Rudenko A, Hartmann R, Hartmann A, Kimmel N, Holl P, Weidenspointner G, Rudek B, Erk B, Kassemeyer S, Schlichting I, Struder L, Ullrich J, Schmidt C, Krasniqi F, Hauser G, Reich C, Soltau H, Schorb S, Hirsemann H, Wunderer C, Graafsma H, Chapman H, Hajdu J (2016) Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser. Sci Data.3 ;:160060,2016 aug - PMID:27479754

  2. Claverie JM, Abergel C (2016) CRISPR-Cas-like system in giant viruses: why MIMIVIRE is not likely to be an adaptive immune system. Virol Sin. ; :,2016 Jun 13 - PMID:27315813

  3. Claverie JM, Abergel C (2016) Giant viruses: The difficult breaking of multiple epistemological barriers. Stud Hist Philos Biol Biomed Sci. ; :,2016 Mar 10 - PMID:26972873

  4. Abergel C, Claverie JM (2016) Diversité des virus géants Virologie, Vol 20, n◦ 1, 2016 jan

  5. Doutre G, Arfib B, Rochette P, Claverie JM, Bonin P, Abergel C (2015) Complete Genome Sequence of a New Member of the Marseilleviridae Recovered from the Brackish Submarine Spring in the Cassis Port-Miou Calanque, France. Genome Announc.3 ;6 :,2011 nov - PMID:26607881

  6. Claverie JM, Abergel C (2015) On a ouvert la glacière de Pandore Biofutur 369 : 54-55.,2015 oct

  7. Abergel C, Legendre M, Claverie JM (2015) The rapidly expanding universe of giant viruses: Mimivirus, Pandoravirus, Pithovirus and Mollivirus. FEMS Microbiol Rev. ; :,2015 Sep 20 - PMID:26391910

  8. Legendre M, Lartigue A, Bertaux L, Jeudy S, Bartoli J, Lescot M, Alempic JM, Ramus C, Bruley C, Labadie K, Shmakova L, Rivkina E, Couté Y, Abergel C, Claverie JM (2015) In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acanthamoeba. Proc Natl Acad Sci U S A. ; :,2015 Sep 8 - PMID:26351664

  9. Priet S, Lartigue A, Debart F, Claverie JM, Abergel C (2015) mRNA maturation in giant viruses: variation on a theme. Nucleic Acids Res. ; :,2015 Mar 16 - PMID:25779049

  10. Ekeberg T, Svenda M, Abergel C, Maia FR, Seltzer V, Claverie JM, Hantke M, Jonsson O, Nettelblad C, van der Schot G, Liang M, DePonte DP, Barty A, Seibert MM, Iwan B, Andersson I, Loh ND, Martin AV, Chapman H, Bostedt C, Bozek JD, Ferguson KR, Krzywinski J, Epp SW, Rolles D, Rudenko A, Hartmann R, Kimmel N, Hajdu J (2015) Three-dimensional reconstruction of the giant mimivirus particle with an x-ray free-electron laser. Phys Rev Lett.114 ;9:098102,2015 Mar 6 - PMID:25793853

  11. Claverie J.-M., Abergel C (2015) Pandoravirus McGraw-Hill Year book of Science and Technology - 2015. (John Renie, ed.) ;pp 226-227 ;ISBN 978-0-07-183576-3 ISSN 0076-2016,2015

  12. Claverie JM, Abergel C (2014) La découverte de Mimivirus redéfinit la notion même de virus. Philippe Cramer (ed.), Le défi des maladies infectieuses, Edition Docis, Paris. , pp 85-89

  13. Lartigue A, Burlat B, Coutard B, Chaspoul F, Claverie JM, Abergel C (2014) The Megavirus chilensis Cu,Zn-Superoxide Dismutase: the first viral structure of a typical CCS-independent hyperstable dimeric enzyme. J Virol. ; :,2014 Oct 29 - PMID:25355875

  14. Doutre G, Philippe N, Abergel C, Claverie JM (2014) Genome analysis of the first Marseilleviridae representative from Australia indicates that most of its genes contribute to the virus fitness. J Virol. ; :,2014 Oct 1 - PMID:25275139

  15. Claverie JM, Abergel C (2014) From extraordinary endocytobionts to Pandoraviruses. Comment on Scheid et al.: Some secrets are revealed: Parasitic keratitis amoebae as vectors of the scarcely described pandoraviruses to humans. Parasitol Res. ; :,2014 Aug 19 - PMID:25134945

  16. Stelter M, Molina R, Jeudy S, Kahn R, Abergel C, Hermoso JA (2014) A complement to the modern crystallographer s toolbox: caged gadolinium complexes with versatile binding modes. Acta Crystallogr D Biol Crystallogr.70 ;Pt 6:1506-16,2014 Jun  - PMID:24914962

  17. Claverie J-M, Abergel C (2014) Paléovirologie : Pithovirus : un virus géant venu du fond des âges Biofutur 33 (352), 50-51,2014 Mar 4

  18. Legendre M, Bartoli J, Shmakova L, Jeudy S, Labadie K, Adrait A, Lescot M, Poirot O, Bertaux L, Bruley C, Couté Y, Rivkina E, Abergel C, Claverie JM (2014) Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology. Proc Natl Acad Sci U S A. ;111 (11) : 4274–4279,2014 Mar 3 - PMID:24591590

  19. Abergel C, Claverie JM (2014) Pithovirus sibericum:awakening of a giant virus of more than 30 000 years. Med Sci (Paris).30 ;3:329-31,2014 Mar  - PMID:24685225

  20. Claverie J.-M. & Abergel C (2013) Les virus sont-ils vraiment des virus ? Virologie 17 : 217-228,2013 Dec 1

  21. Philippe N, Legendre M, Doutre G, Couté Y, Poirot O, Lescot M, Arslan D, Seltzer V, Bertaux L, Bruley C, Garin J, Claverie JM, Abergel C (2013) Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. Science.341 ;6143:281-6,2013 Jul 19 - PMID:23869018

  22. Santini S, Jeudy S, Bartoli J, Poirot O, Lescot M, Abergel C, Barbe V, Wommack KE, Noordeloos AA, Brussaard CP, Claverie JM (2013) Genome of Phaeocystis globosa virus PgV-16T highlights the common ancestry of the largest known DNA viruses infecting eukaryotes. Proc Natl Acad Sci U S A.110 ;26:10800-5,2013 Jun 25 - PMID:23754393

  23. Piacente F, Bernardi C, Marin M, Blanc G, Abergel C, Tonetti MG (2013) Characterization of a UDP-N-acetylglucosamine biosynthetic pathway encoded by the giant DNA virus Mimivirus. Glycobiology. ; :,2013 Oct 9 - PMID:24107487

  24. Claverie JM, Abergel C (2013) Open questions about giant viruses. Adv Virus Res.85 ;:25-56,2013  - PMID:23439023

  25. Lartigue A, Jeudy S, Bertaux L, Abergel C (2013) Preliminary crystallographic analysis of a polyadenylate synthase from Megavirus. Acta Crystallogr Sect F Struct Biol Cryst Commun.69 ;Pt 1:53-6,2013 Jan 1 - PMID:23295487

  26. Jeudy S, Abergel C, Claverie JM, Legendre M (2012) Translation in giant viruses: a unique mixture of bacterial and eukaryotic termination schemes. PLoS Genet.8 ;12:e1003122,2012 Dec  - PMID:23271980

  27. Lartigue A, Philippe N, Jeudy S, Abergel C (2012) Preliminary crystallographic analysis of the Megavirus superoxide dismutase. Acta Crystallogr Sect F Struct Biol Cryst Commun.68 ;Pt 12:1557-9,2012 Dec 1 - PMID:23192047

  28. Claverie JM, Abergel C (2012) The Concept of Virus in the Post-Megavirus Era Springer, Guenther Witzany Editor, Viruses : Essential Agents of Life : 187-202,2012 November

  29. Claverie JM, Abergel C (2012) Les virus géants, vestiges d'organismes cellulaires. Pour la Science 415 : 30-33,2012 May

  30. Piacente F, Marin M, Molinaro A, De Castro C, Seltzer V, Salis A, Damonte G, Bernardi C, Claverie JM, Abergel C, Tonetti M (2012) Giant DNA Virus Mimivirus Encodes Pathway for Biosynthesis of Unusual Sugar 4-Amino-4,6-dideoxy-D-glucose (Viosamine). J Biol Chem.287 ;5:3009-18,2012 Jan 27 - PMID:22157758

  31. Legendre M, Arslan D, Abergel C, Claverie JM (2012) Genomics of Megavirus and the elusive fourth domain of Life. Commun Integr Biol.5 ;1:102-6,2012 Jan 1 - PMID:22482024

  32. Claverie JM, Abergel C (2011) Megavirus réécrit l'évolution des virus à ADN. Biofutur 327 (Décembre, p11),2011

  33. Arslan D, Legendre M, Seltzer V, Abergel C, Claverie JM (2011) Distant Mimivirus relative with a larger genome highlights the fundamental features of Megaviridae. Proc Natl Acad Sci U S A.108 ;42:17486-91,2011 Oct 18 - PMID:21987820

  34. Yoon CH, Schwander P, Abergel C, Andersson I, Andreasson J, Aquila A, Bajt S, Barthelmess M, Barty A, Bogan MJ, Bostedt C, Bozek J, Chapman HN, Claverie JM, Coppola N, DePonte DP, Ekeberg T, Epp SW, Erk B, Fleckenstein H, Foucar L, Graafsma H, Gumprecht L, Hajdu J, Hampton CY, Hartmann A, Hartmann E, Hartmann R, Hauser G, Hirsemann H, Holl P, Kassemeyer S, Kimmel N, Kiskinova M, Liang M, Loh NT, Lomb L, Maia FR, Martin AV, Nass K, Pedersoli E, Reich C, Rolles D, Rudek B, Rudenko A, Schlichting I, Schulz J, Seibert M, Seltzer V, Shoeman RL, Sierra RG, Soltau H, Starodub D, Steinbrener J, Stier G, Strüder L, Svenda M, Ullrich J, Weidenspointner G, White TA, Wunderer C, Ourmazd A (2011) Unsupervised classification of single-particle X-ray diffraction snapshots by spectral clustering. Opt Express.19 ;17:16542-9,2011 Aug 15 - PMID:21935018

  35. Legendre M, Santini S, Rico A, Abergel C, Claverie JM (2011) Breaking the 1000-gene barrier for Mimivirus using ultra-deep genome and transcriptome sequencing. Virol J.8 ;1:99,2011 Mar 4 - PMID:21375749

  36. Seibert MM, Ekeberg T, Maia FR, Svenda M, Andreasson J, Jonsson O, Odic D, Iwan B, Rocker A, Westphal D, Hantke M, Deponte DP, Barty A, Schulz J, Gumprecht L, Coppola N, Aquila A, Liang M, White TA, Martin A, Caleman C, Stern S, Abergel C, Seltzer V, Claverie JM, Bostedt C, Bozek JD, Boutet S, Miahnahri AA, Messerschmidt M, Krzywinski J, Williams G, Hodgson KO, Bogan MJ, Hampton CY, Sierra RG, Starodub D, Andersson I, Bajt S, Barthelmess M, Spence JC, Fromme P, Weierstall U, Kirian R, Hunter M, Doak RB, Marchesini S, Hau-Riege SP, Frank M, Shoeman RL, Lomb L, Epp SW, Hartmann R, Rolles D, Rudenko A, Schmidt C, Foucar L, Kimmel N, Holl P, Rudek B, Erk B, Homke A, Reich C, Pietschner D, Weidenspointner G, Struder L, Hauser G, Gorke H, Ullrich J, Schlichting I, Herrmann S, Schaller G, Schopper F, Soltau H, Kuhnel KU, Andritschke R, Schroter CD, Krasniqi F, Bott M, Schorb S, Rupp D, Adolph M, Gorkhover T, Hirsemann H, Potdevin G, Graafsma H, Nilsson B, Chapman HN, Hajdu J (2011) Single mimivirus particles intercepted and imaged with an X-ray laser. Nature.470 ;7332:78-81,2011 Feb 3 - PMID:21293374

  37. Jeudy S, Lartigue A, Mansuelle P, Ogata Y, Abergel C (2011) The mimivirus R355 gene product: preliminary crystallographic analysis of a putative ubiquitin-like protein-specific protease. Acta Crystallogr Sect F Struct Biol Cryst Commun.67 ;Pt 1:169-72,2011 Jan 1 - PMID:21206054

  38. Santini S, Claverie JM, Mouz N, Rousselle T, Maza C, Monchois V, Abergel C (2011) The Conserved Candida albicans CA3427 Gene Product Defines a New Family of Proteins Exhibiting the Generic Periplasmic Binding Protein Structural Fold. PLoS One.6 ;4:e18528,2011  - PMID:21494601

  39. Claverie JM, Abergel C (2011) Family Mimiviridae. Virus Taxonomy, ninth report of the International Committee on Taxonomy of Viruses (ICTV) , Elsevier, Academic Press, ISBN : 978-0-12-384684-6. pp223-228,2011

  40. Ciaccafava A, Lartigue A, Mansuelle P, Jeudy S, Abergel C (2011) Preliminary crystallographic analysis of a possible transcription factor encoded by the mimivirus L544 gene. Acta Crystallogr Sect F Struct Biol Cryst Commun.67 ;Pt 8:922-5,2011 Aug 1 - PMID:21821896

  41. Legendre M, Audic S, Poirot O, Hingamp P, Seltzer V, Byrne D, Lartigue A, Lescot M, Bernadac A, Poulain J, Abergel C, Claverie JM (2010) mRNA deep sequencing reveals 75 new genes and a complex transcriptional landscape in Mimivirus. Genome Res.20 ;5:664-74,2010 May - PMID:20360389

  42. Parakkottil-Chothi M, Duncan GA, Armirotti A, Abergel C, Gurnon JR, Van Etten JL, Bernardi C, Damonte G, Tonetti M (2010) Identification of an L-rhamnose synthetic pathway in two nucleo-cytoplasmic large dna viruses. J Virol.84 ;17:8829-38,2010 Sep - PMID:20538863

  43. Claverie JM, Abergel C (2010) Mimivirus: the emerging paradox of quasi-autonomous viruses. Trends Genet. ;pp. 431-437 :,2010 Aug 7 - PMID:20696492

  44. Trapani S, Schoehn G, Navaza J, Abergel C (2010) Macromolecular crystal data phased by negative-stained electron-microscopy reconstructions. Acta Crystallogr D Biol Crystallogr.66 ;Pt 5:514-21,2010 May  - PMID:20445226

  45. Claverie JM, Grzela R, Lartigue A, Bernadac A, Nitsche S, Vacelet J, Ogata H, Abergel C (2009) Mimivirus&Mimiviridae: giant viruses with an increasing number of potential hosts, including corals and sponges. J Invertebr Pathol.101 ;3:172-80,2009 Jul - PMID:19457438

  46. Jeudy S, Lartigue A, Claverie JM, Abergel C (2009) Dissecting the unique nucleotide specificity of Mimivirus nucleoside diphosphate kinase. J Virol.83 ;14:7142-50,2009 Jul - PMID:19439473

  47. Claverie JM, Abergel C (2009) Mimivirus and its Virophage. Annu Rev Genet.43 ;:49-66,2009 - PMID:19653859

  48. Claverie JM, Abergel C, Ogata H (2009) Mimivirus. Curr Top Microbiol Immunol.328 ;:89-121,2009  - PMID:19216436

  49. Byrne D, Grzela R, Lartigue A, Audic S, Chenivesse S, Encinas S, Claverie JM, Abergel C (2009) The polyadenylation site of Mimivirus transcripts obeys a stringent hairpin rule. Genome Res.19 ;7:1233-42,2009 Jul  - PMID:19403753

  50. Vallenet D, Nordmann P, Barbe V, Poirel L, Mangenot S, Bataille E, Dossat C, Gas S, Kreimeyer A, Lenoble P, Oztas S, Poulain J, Segurens B, Robert C, Abergel C, Claverie JM, Raoult D, Médigue C, Weissenbach J, Cruveiller S (2008) Comparative analysis of Acinetobacters: three genomes for three lifestyles. PLoS ONE.3 ;3:e1805,2008  - PMID:18350144

  51. Santini S, Monchois V, Mouz N, Sigoillot C, Rousselle T, Claverie JM, Abergel C (2008) Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase. BMC Struct Biol.8 ;:33,2008  - PMID:18652651

  52. Abergel C, Rudinger-Thirion J , Giegé R, Claverie JM (2007) Virus-Encoded Aminoacyl-tRNA Synthetases: Structural and Functional Characterization of Mimivirus TyrRS and MetRS. J Virol.81 ;22:12406-17,2007 Nov - PMID:17855524

  53. Abergel C, Monchois V, Byrne D, Chenivesse S, Lembo F, Lazzaroni JC, Claverie JM (2007) Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria. Proc Natl Acad Sci U S A.104 ;15:6394-9,2007 Apr 10 - PMID:17405861

  54. Abergel C , Blanc G , Monchois V, Renesto P, Sigoillot C , Ogata H, Raoult D, Claverie JM (2006) Impact of the excision of an ancient repeat insertion on Rickettsia conorii guanylate kinase activity. Mol Biol Evol.23 ;11:2112-22,2006 Nov - PMID:16891376

  55. Trapani S, Abergel C, Gutsche I, Horcajada C, Fita I, Navaza J (2006) Combining experimental data for structure determination of flexible multimeric macromolecules by molecular replacement. Acta Crystallogr D Biol Crystallogr.62 ;Pt 5:467-75,2006 May - PMID:16627938

  56. Claverie JM, Ogata H, Audic S, Abergel C, Suhre K, Fournier PE (2006) Mimivirus and the emerging concept of "giant" virus. Virus Res.117 ;1:133-44,2006 Apr - PMID:16469402

  57. Fournier PE, Vallenet D, Barbe V, Audic S, Ogata H, Poirel L, Richet H, Robert C, Mangenot S, Abergel C, Nordmann P, Weissenbach J, Raoult D, Claverie JM (2006) Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet.2 ;1:e7,2006 Jan - PMID:16415984

  58. Jeudy S, Claverie JM, Abergel C (2006) The nucleoside diphosphate kinase from mimivirus: a peculiar affinity for deoxypyrimidine nucleotides. J Bioenerg Biomembr.38 ;3-4:247-54,2006 Aug  - PMID:16957983

  59. Jeudy S, Stelter M, Coutard B, Kahn R, Abergel C (2005) Preliminary crystallographic analysis of the Escherichia coli YeaZ protein using the anomalous signal of a gadolinium derivative. Acta Crystallogr Sect F Struct Biol Cryst Commun.61 ;Pt 9:848-51,2005 Sep 1 - PMID:16511176

  60. Ogata H, Abergel C, Raoult D, Claverie JM (2005) Response to Comment on The 1.2-Megabase Genome Sequence of Mimivirus Science, Vol 308, Issue 5725, 1114 Science, Vol 308, Issue 5725, 1114,2005 Jun

  61. Jeudy S, Coutard B, Lebrun R, Abergel C (2005) Acanthamoeba polyphaga mimivirus NDK: preliminary crystallographic analysis of the first viral nucleoside diphosphate kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun.61 ;Pt 6:569-72,2005 Jun 1 - PMID:16511098

  62. Malarte G, Leroy G, Lojou E, Abergel C, Bruschi M, Giudici-Orticoni MT. (2005) Insight into Molecular Stability and Physiological Properties of the Diheme Cytochrome CYC(41) from the Acidophilic Bacterium Acidithiobacillus ferrooxidans. Biochemistry ;44(17):6471-81,2005 May 3 - PMID:15850381

  63. Abergel C, Chenivesse S, Byrne D, Suhre K, Arondel V, Claverie JM (2005) Mimivirus TyrRS: preliminary structural and functional characterization of the first amino-acyl tRNA synthetase found in a virus. Acta Crystallogr Sect F Struct Biol Cryst Commun.61 ;Pt 2:212-5,2005 Feb 1 - PMID:16510997

  64. Raoult D, Audic S, Robert C, Abergel C, Renesto P, Ogata H, La Scola B, Suzan M, Claverie JM. (2004) The 1.2-Mb Genome Sequence of Mimivirus. Science. 2004 Nov 19 ;306(5700):1344-50. Epub 2004 Oct 14. - PMID:15486256

  65. Abergel C. (2004) Spectacular improvement of X-ray diffraction through fast desiccation of protein crystals. Acta Crystallogr D Biol Crystallogr. 2004 Aug ;60(Pt 8):1413-6. - PMID:15272164

  66. Poirot O, Suhre K, Abergel C, O'Toole E, Notredame C (2004) 3DCoffee@igs: a web server for combining sequences and structures into a multiple sequence alignment. Nucleic Acids Res. 2004 Jul 1 ;32(Web Server issue):W37-40. - PMID:15215345

  67. Claude JB, Suhre K, Notredame C, Claverie JM, Abergel C (2004) CaspR: a web-server for automated molecular replacement using homology modelling. Nucleic Acids Res. 2004 Jul 1 ;32(Web Server issue):W606-9. - PMID:15215460

  68. Enault F, Suhre K, Poirot O, Abergel C, Claverie JM (2004) Phydbac2: improved inference of gene function using interactive phylogenomic profiling and chromosomal location analysis Nucleic Acids Res. 2004 Jul 1 ;32(Web Server issue):W336-9. - PMID:15215406

  69. O'Sullivan O, Suhre K, Abergel C, Higgins DG, Notredame C. (2004) 3DCoffee: combining protein sequences and structures within multiple sequence alignments. J Mol Biol. 2004 Jul 2 ;340(2):385-95. - PMID:15201059

  70. Enault F, Suhre K, Poirot O, Abergel C, Claverie JM (2003) Phydbac (phylogenomic display of bacterial genes): An interactive resource for the annotation of bacterial genomes. Nucleic Acids Res 2003 Jul 1 ;31(13):3720-2. - PMID:12824402

  71. Abergel C, Nitschke W, Malarte G, Bruschi M, Claverie JM, Giudici-Orticoni MT (2003) The structure of Acidithiobacillus ferrooxidans c(4)-cytochrome: a model for complex-induced electron transfer tuning. Structure (Camb) 2003 May ;11(5):547-55. - PMID:12737820

  72. Abergel C, Coutard B, Byrne D, Chenivesse S, Claude JB, Deregnaucourt C, Fricaux T, Gianesini-Boutreux C, Jeudy S, Lebrun R, Maza C, Notredame C, Poirot O, Suhre K, Varagnol M, Claverie JM. (2003) Structural genomics of highly conserved microbial genes of unknown function in search of new antibacterial targets. J Struct Funct Genomics. 2003 ;4(2-3):141-57. - PMID:14649299

  73. Notredame C. and Abergel C. (2003) Using T-Coffee to assess the reliability of multiple sequence alignments. Bioinformatics and Genomes (M.A. Andrade, ed.) Horizon Scientific Press, Wymondham,UK, pp 27-49

  74. Claverie JM, Monchois V, Audic S, Poirot O, Abergel C (2002) In Search of new anti-bacterial target genes: a comparative/structural genomics approach. Comb Chem High Throughput Screen 2002 Nov ;5(7):511-22. - PMID:12470264

  75. Ogata H, Audic S, Abergel C, Fournier PE, Claverie JM (2002) Protein coding palindromes are a unique but recurrent feature in Rickettsia. Genome Res 2002 May ;12(5):808-16. - PMID:11997347

  76. Monchois V., Vincentelli R., Abergel C., Deregnaucourt C., Claverie J.-M. and Monchois V. (2002) Proficient target selection in structural genomic by In vitro protein expression on Gateway recombination plasmids. Cell-Free Translation Systems (Spirin Ed.) Springer Verlag : () 197- 202.

  77. Claverie JM, Abergel C, Audic S, Ogata H (2001) Recent advances in computational genomics. Pharmacogenomics 2001 Nov ;2(4):361-72. - PMID:11722286

  78. Maurin M, Abergel C, Raoult D (2001) DNA gyrase-mediated natural resistance to fluoroquinolones in Ehrlichia spp. Antimicrob Agents Chemother 2001 Jul ;45(7):2098-105. - PMID:11408229

  79. Monchois V, Abergel C, Sturgis J, Jeudy S, Claverie JM (2001) Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme. J Biol Chem 2001 May 25 ;276(21):18437-41. - PMID:11278658

  80. Abergel C, Walburger A, Chenivesse S, Lazdunski C (2001) Crystallization and preliminary crystallographic study of the peptidoglycan-associated lipoprotein from Escherichia coli. Acta Crystallogr D Biol Crystallogr 2001 Feb ;57(Pt 2):317-9. - PMID:11173492

  81. Abergel C, Abousalham A, Chenivesse S, Riviere M, Moustacas-Gardies AM, Verger R (2001) Crystallization and preliminary crystallographic study of a recombinant phospholipase D from cowpea (Vigna unguiculata L. Walp). Acta Crystallogr D Biol Crystallogr 2001 Feb ;57(Pt 2):320-2. - PMID:11173493

  82. Abergel C, Journet L, Chenivesse S, Gavioli M, Lloubes R (2001) Crystallization and preliminary crystallographic study of the periplasmic domain of the Escherichia coli TolR protein. Acta Crystallogr D Biol Crystallogr 2001 Feb ;57(Pt 2):323-5. - PMID:11173494

  83. Abergel C, Monchois V, Chenivesse S, Jeudy S, Claverie JM (2000) Crystallization and preliminary crystallographic study of b0220, an 'ORFan' protein of unknown function from Escherichia coli. Acta Crystallogr D Biol Crystallogr 2000 Dec ;56 Pt 12:1694-5. - PMID:11092949

  84. Abergel C, Bruschi M, Chenivesse S, Guasco S, Leroy G, Guidici-Orticoni MT (2000) Crystallization and preliminary crystallographic study of an extremophile cytochrome c4 from Thiobacillus ferrooxidans. Acta Crystallogr D Biol Crystallogr 2000 Nov ;56 ( Pt 11):1432-3. - PMID:11053842

  85. Abergel C, Bouveret E, Claverie JM, Brown K, Rigal A, Lazdunski C, Benedetti H (1999) Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution. Structure Fold Des 1999 Oct 15 ;7(10):1291-300. - PMID:10545334

  86. Abergel C, Robertson DL, Claverie JM (1999) Hidden dUTPase sequence in human immunodeficiency virus type 1 gp120. J Virol 1999 Jan ;73(1):751-3. - PMID:9847382

  87. Claverie J.-M., Lopez F. and Abergel C (1999) A New Strategy and Software System for the Design of Functional Signatures in Protein Sequences, in Perspective in Structural Biology. Indian Acad. Sciences and the Universities Press,Hyderabad, India.(M. Vijayan, ed.). Chap. 51 : () 680- 700.

  88. Abergel C, Chavrier P, Claverie JM (1998) Triple association of CDC25-, Dbl- and Sec7-related domains in mammalian guanine-nucleotide-exchange factors. Trends Biochem Sci 1998 Dec ;23(12):472-3. - PMID:9868368

  89. Abergel C, Rigal A, Chenivesse S, Lazdunski C, Claverie JM, Bouveret E, Benedetti H (1998) Crystallization and preliminary crystallographic study of a component of the Escherichia coli tol system: TolB. Acta Crystallogr D Biol Crystallogr 1998 Jan 1 ;54 ( Pt 1):102-4. - PMID:9761825

  90. Audic S, Lopez F, Claverie JM, Poirot O, Abergel C (1997) SAmBA: an interactive software for optimizing the design of biological macromolecules crystallization experiments. Proteins 1997 Oct ;29(2):252-7. - PMID:9329089

  91. Bruschi M, Woudstra M, Guigliarelli B, Asso M, Lojou E, Petillot Y, Abergel C (1997) Biochemical and spectroscopic characterization of two new cytochromes isolated from Desulfuromonas acetoxidans. Biochemistry 1997 Sep 2 ;36(35):10601-8. - PMID:9271490

  92. Padlan EA, Abergel C, Tipper JP (1995) Identification of specificity-determining residues in antibodies. FASEB J 1995 Jan ;9(1):133-9. - PMID:7821752

  93. Abergel C, Tipper JP, Padlan EA (1994) Structural significance of sequence variability in antibody complementarity-determining regions. Res Immunol 1994 Jan ;145(1):49-53. - PMID:8008969

  94. Abergel C, Padlan EA, Kashmiri SV, Milenic D, Calvo B, Schlom J (1993) Crystallographic studies and primary structure of the antitumor monoclonal CC49 Fab'. Proteins 1993 Dec ;17(4):438-43. - PMID:8108385

  95. Moreau H, Abergel C, Carriere F, Ferrato F, Fontecilla-Camps JC, Cambillau C, Verger R (1992) Isoform purification of gastric lipases. Towards crystallization. J Mol Biol 1992 May 5 ;225(1):147-53. - PMID:1583687

  96. Abergel C, Claverie JM (1991) A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci. Eur J Immunol 1991 Dec ;21(12):3021-5. - PMID:1660812

  97. Abergel C, Moulard M, Moreau H, Loret E, Cambillau C, Fontecilla-Camps JC (1991) Systematic use of the incomplete factorial approach in the design of protein crystallization experiments. J Biol Chem 1991 Oct 25 ;266(30):20131-8. - PMID:1939074

  98. Devaux C, Defendini ML, Alzari PM, Abergel C, Granier C, Fontecilla-Camps JC, Alzar PM (1991) Crystallization and preliminary X-ray diffraction data of the Fab fragment of a monoclonal antibody against apamin, a bee venom neurotoxin. FEBS Lett 1991 Jul 29 ;286(1-2):64-6. - PMID:1747157

  99. Abergel C, Martinez C, Fontecilla-Camps J, Cambillau C, de Geus P, Lauwereys M (1990) Crystallization and preliminary X-ray study of a recombinant cutinase from Fusarium solani pisi. J Mol Biol 1990 Sep 20 ;215(2):215-6. - PMID:2213880

  100. Abergel C, Loret E, Rochat H, Fontecilla-Camps JC (1990) Crystallization and preliminary X-ray study of AaH IT2, and insect-specific toxin from the scorpion Androctonus australis Hector. J Mol Biol 1990 Aug 5 ;214(3):637-8. - PMID:2388262

  101. Bourne Y, Abergel C, Cambillau C, Frey M, Rouge P, Fontecilla-Camps JC (1990) X-ray crystal structure determination and refinement at 1.9 A resolution of isolectin I from the seeds of Lathyrus ochrus. J Mol Biol 1990 Jul 20 ;214(2):571-84. - PMID:2380988

  102. Abergel C, Loret E, Claverie JM (1989) Conformational analysis of T immunogenic peptides by circular dichroism spectroscopy. Eur J Immunol 1989 Oct ;19(10):1969-72. - PMID:2511030